The histology of brain tumors for 67 331 children and 671 085 adults diagnosed in 60 countries during 2000-2014: a global, population-based study (CONCORD-3)
Fabio Girardi(University College London Hospitals NHS Foundation Trust), Brian Rous(Public Health England), Charles Stiller(Public Health England), Gemma Gatta(Fondazione IRCCS Istituto Nazionale dei Tumori), Naomi Fersht(University College London Hospitals NHS Foundation Trust), Hans H. Storm(Danish Cancer Society), Jéssica Rodrigues, C. Herrmann, Rafael Marcos‐Gragera(Clínica Girona), Rafael Peris‐Bonet, М. Yu. Valkov(Arkhangel'skiy Klinicheskiy Onkologicheskiy Dispanser), Hannah K Weir(Centers for Disease Control and Prevention), Ryan Woods(BC Cancer Agency), Hui You(Cancer Australia), Patricia Cueva(Universidad San Francisco de Quito), Prithwish De, V Di Carlo(London Cancer), Tom Børge Johannesen(Cancer Registry of Norway), Carlos Anselmo Lima, Charles F. Lynch, Michel P. Coleman(University College London Hospitals NHS Foundation Trust), Claudia Allemani(London Cancer), CONCORD Working Group, S. Bouzbid(London Cancer), M Hamdi-Chérif, Zoubida Zaidi(Cancer Institute (WIA)), Kaouel Meguenni(London Cancer), D. Regagba, Saray Mormeneo Bayo(Cancer Registry of Norway), T Cheick Bougadari, S S Manraj(Cancer Institute (WIA)), Karima Bendahhou, A Ladipo, Olufemi J. Ogunbiyi(Cancer Registry of Norway), Thendo Ramaliba, Nontuthuzelo Somdyala(London Cancer), M A Chaplin, Florencia Moreno, G.H. Calabrano, S.B. Espinola(Cancer Registry of Norway), B Carballo Quintero(Cancer Institute (WIA)), R Fita, W.D. Laspada(Clínica Girona), S.G. Ibañez, Carlos Anselmo Lima, A Mafra da Costa, P.C.F. De Souza(Cancer Institute (WIA)), K Del Pino(London Cancer), C. Laporte, María Paula Curado, José Carlos de Oliveira(London Cancer), C.L.A. Veneziano, Donaldo Botelho Veneziano, M R D O Latorre, Luana Fiengo Tanaka, Marise Souto Rebelo, M O Santos(Cancer Institute (WIA)), Gulnar Azevedo e Silva, J.C. Galaz(London Cancer), M Aparicio Aravena(Cancer Registry of Norway), J Sanhueza Monsalve, D.A. Herrmann, S Torres Vargas, Víctor Herrera, Claudia Uribe(London Cancer), Luis Eduardo Bravo, Luz Stella García(Cancer Registry of Norway), Nelson Enrique Arias-Ortiz(London Cancer), D Morantes, Daniel Jurado, María Clara Yépez Chamorro, Sandra Delgado(London Cancer), Melissa Ramirez, Y H Galán Alvarez(Cancer Institute (WIA)), Priscila Torres, F Martínez-Reyes(London Cancer), L. Jaramillo(Cancer Institute (WIA)), R. Quinto(Cancer Registry of Norway), J Castillo(London Cancer), M Mendoza(Universidad San Francisco de Quito), Patricia Cueva(Universidad San Francisco de Quito), J.G. Yépez(Cancer Registry of Norway), Bernard Bhakkan(Cancer Registry of Norway), Jacqueline Deloumeaux(London Cancer), Clarisse Joachim(Cancer Registry of Norway), Jonathan Macni(Cancer Institute (WIA)), R Carrillo(Cancer Registry of Norway), J Shalkow Klincovstein(Cancer Institute (WIA)), Rebeca Rivera-Gómez(Cancer Institute (WIA)), P Pérez(London Cancer), Ebert Poquioma(Cancer Institute (WIA)), Guillermo Tortolero‐Luna(London Cancer), Diego Zavala(Cancer Institute (WIA)), R. Alonso(London Cancer), Enrique Barrios, Angela Eckstrand(London Cancer), C Nikiforuk(BC Cancer Agency), Ryan Woods(BC Cancer Agency), Glen Noonan(London Cancer), Donna Turner(London Cancer), Eshwar Kumar(Cancer Registry of Norway), B Zhang, F.R. McCrate(BC Cancer Agency), S. Ryan(London Cancer), M Macintyre(Cancer Institute (WIA)), Nathalie Saint‐Jacques, A Anam, P De(London Cancer), C A McClure(Cancer Institute (WIA)), K.A. Vriends(London Cancer), Christine Bertrand(Cancer Registry of Norway), Jean Latreille, Serena Kozie(University College London Hospitals NHS Foundation Trust), H. Stuart-Panko(Cancer Registry of Norway), T Freeman, J T George, Rosa M. Avila, David K. O’Brien, A Holt(London Cancer), Lyn Almon, Sandy Kwong(London Cancer), Cyllene R. Morris(Cancer Institute (WIA)), R Rycroft(London Cancer), Lloyd Mueller, Cathryn Phillips(University College London Hospitals NHS Foundation Trust), Heather M. Brown(Cancer Registry of Norway), B Cromartie(Cancer Institute (WIA)), Ann G. Schwartz, Fawn D. Vigneau, G M Levin(Cancer Registry of Norway), Brad Wohler(Cancer Institute (WIA)), Rana Bayakly, Kevin C. Ward, Scarlett Lin Gomez(London Cancer), Meg McKinley(Cancer Institute (WIA)), Rosemary D. Cress, M D Green(Cancer Institute (WIA)), K Miyagi, Christopher J. Johnson(University College London Hospitals NHS Foundation Trust), Laura Ruppert, Suzanne Bentler, Martin Charlton(Cancer Registry of Norway), Bin Huang(University of Kentucky), T. C. Tucker(London Cancer), Dennis Deapen(London Cancer), L Liu, Mei‐Chin Hsieh, Xiao‐Cheng Wu(London Cancer), Molly Schwenn(Cancer Institute (WIA)), Kimberly J. Stern, S T Gershman(Clínica Girona), Richard Knowlton(Cancer Institute (WIA)), Georgetta Alverson(Cancer Registry of Norway), Timothy D. Weaver, Sally Bushhouse, D B Rogers(Cancer Registry of Norway), J Jackson-Thompson(London Cancer), D Lemons, H J Zimmerman(London Cancer), Michelle M. Hood(Cancer Registry of Norway), J Roberts-Johnson(Cancer Registry of Norway), Bruce L. Riddle, Judy R. Rees, Karen Pawlish, Antoinette M. Stroup(London Cancer), Cas Key(London Cancer), Charles L. Wiggins(Cancer Institute (WIA)), Amy R. Kahn, Maria J. Schymura, S Radhakrishnan(London Cancer), Chandrika Rao(Arkhangel'skiy Klinicheskiy Onkologicheskiy Dispanser), L K Giljahn, R M Slocumb, A Feld, K G Aird(Cancer Registry of Norway), T Beran, J J Rubertone, S J Slack(Cancer Registry of Norway), Jae Hwan Oh(Cancer Registry of Norway), T A Janes, Stephen M. Schwartz, S Chiodini, Deborah Hurley(London Cancer), Martin Whiteside, Saroj Rai(London Cancer), Melanie Williams(Cancer Institute (WIA)), Kim Herget(London Cancer), Carol Sweeney(Cancer Registry of Norway), Alison Johnson(Cancer Registry of Norway), M B Keitheri Cheteri(Cancer Institute (WIA)), Patti Migliore Santiago(Cancer Registry of Norway), S E Blankenship, S Farley(Cancer Institute (WIA)), R.R. Borchers(Cancer Institute (WIA)), R Malicki(Cancer Registry of Norway), J Espinoza(Cancer Registry of Norway), Joseph Grandpre(Centers for Disease Control and Prevention), H.K. Weir(Centers for Disease Control and Prevention), Reda Wilson, B. K. Edwards, A Mariotto(Cancer Institute (WIA)), Ning Wang(London Cancer), Lei Yang, J S Chen, Yanjun Zhou(University College London Hospitals NHS Foundation Trust), Yufang He, G H Song, Xiaoping Gu(London Cancer), Dan Mei, Huijuan Mu(Cancer Registry of Norway), H M Ge, T H Wu, Y Y Li, Di Zhao, F Jin, J H Zhang, F D Zhu, Q Junhua, Y L Yang, C X Jiang(Cancer Institute (WIA)), W Biao(Cancer Registry of Norway), J Wang, Q L Li(University College London Hospitals NHS Foundation Trust), H Yi, Xin Zhou(Cancer Registry of Norway), Jie Dong, W Li, F X Fu, S Z Liu, Jianguo Chen(Cancer Registry of Norway), Jian Zhu, Y H Li, Yuqiang Lu(London Cancer), Min Fan, Suqin Huang, G P Guo(University College London Hospitals NHS Foundation Trust), Hua Zhao-lai(Centers for Disease Control and Prevention), Kuangrong Wei, W-Q Chen(Centers for Disease Control and Prevention), Wenqiang Wei(University College London Hospitals NHS Foundation Trust), Hongmei Zeng(London Cancer), A Demetriou, W.K. Mang, K.C. Ngan(London Cancer), A.C. Kataki(London Cancer), Manigreeva Krishnatreya(Cancer Institute (WIA)), P A Jayalekshmi(Cancer Institute (WIA)), P. Sebastian, Preethi Sara George, A. Mathew, A Nandakumar(Cancer Institute (WIA)), Reza Malekzadeh(Cancer Institute (WIA)), Gholamreza Roshandel(London Cancer), Lital Keinan-Boker, Barbara Silverman, Yuriko N. Koyanagi(University College London Hospitals NHS Foundation Trust), Hidemi Ito(London Cancer), M Sato, F Tobori(Cancer Institute (WIA)), I Nakata(Cancer Institute (WIA)), N Teramoto(London Cancer), Masaya Hattori, Yasuharu Kaizaki, Fumitaka Moki(University College London Hospitals NHS Foundation Trust), Hiromi Sugiyama(London Cancer), Mai Utada(London Cancer), M Nishimura(Cancer Institute (WIA)), Keisuke Yoshida(Cancer Institute (WIA)), K Kurosawa, Y Nemoto(University College London Hospitals NHS Foundation Trust), Hiroto Narimatsu(London Cancer), Masahiko Sakaguchi, Seiki Kanemura(London Cancer), Michiko Naito(Cancer Institute (WIA)), Rintaro Narisawa(Cancer Institute (WIA)), Isao Miyashiro(Cancer Institute (WIA)), Kayo Nakata, Akihiro Maeda, S Sato(Cancer Institute (WIA)), Izumi Oki(Cancer Institute (WIA)), Noriyoshi Fukushima, Akiko Shibata(Cancer Institute (WIA)), K Iwasa(London Cancer), Chikako Ono(Cancer Registry of Norway), Tomohiro Matsuda(Cancer Institute (WIA)), Omar Nimri(Centers for Disease Control and Prevention), Kyu‐Won Jung, Young‐Joo Won(London Cancer), Eiman Alawadhi, A Elbasmi, Azizah Ab Manan, Farzaana Adam(London Cancer), E Nansalmaa(Cancer Institute (WIA)), Undarmaa Tudev(London Cancer), Chimedsuren Оchir(London Cancer), A M Al Khater(Fondazione IRCCS Istituto Nazionale dei Tumori), M.M. El Mistiri, G H Lim, Yik Ying Teo, Chun‐Ju Chiang, W C Lee(Cancer Institute (WIA)), R Buasom, Suleeporn Sangrajrang(Cancer Institute (WIA)), Krittika Suwanrungruang(Cancer Institute (WIA)), Patravoot Vatanasapt(Cancer Institute (WIA)), Karnchana Daoprasert(London Cancer), D Pongnikorn, Atit Leklob, S Sangkitipaiboon, Sarayut Lucien Geater(University College London Hospitals NHS Foundation Trust), Hutcha Sriplung(Cancer Institute (WIA)), O Ceylan(Cancer Institute (WIA)), İskender Kög(Cancer Institute (WIA)), Oya Dirican(Cancer Registry of Norway), T Köse(Cancer Registry of Norway), T Gurbuz(University College London Hospitals NHS Foundation Trust), F E Karaşahin(London Cancer), D Turhan(Cancer Institute (WIA)), U Aktaş, Y Halat, Sultan Eser(Universidad San Francisco de Quito), Cankut Yakut(London Cancer), M Altinisik, Y Cavusoglu, A Türkköylü(Cancer Institute (WIA)), N Üçüncü(London Cancer), Monika Hackl, A. Zborovskaya(Arkhangel'skiy Klinicheskiy Onkologicheskiy Dispanser), Olga Aleinikova(Cancer Institute (WIA)), K. Henau(London Cancer), Liesbet Van Eycken, Z. Valerianova, Mariya Yordanova(London Cancer), Mario Šekerija(London Cancer), Ladislav Dušek(London Cancer), Miroslav Zvolský(London Cancer), Lina Steinrud Mørch(Danish Cancer Society), Hans H. Storm(London Cancer), Charlotte Wessel Skovlund(Cancer Institute (WIA)), Kaire Innos(London Cancer), Margit Mägi(Cancer Institute (WIA)), Nea Malila(Cancer Institute (WIA)), Karri Seppä(Cancer Registry of Norway), Jérémie Jegu(London Cancer), Michel Velten(London Cancer), Édouard Cornet, Xavier Troussard(London Cancer), Anne‐Marie Bouvier(London Cancer), A.V. Guizard(London Cancer), Véronique Bouvier(Cancer Institute (WIA)), Guy Launoy(Cancer Institute (WIA)), P. Arveux(London Cancer), Marc Maynadié(London Cancer), Morgane Mounier, Anne‐Sophie Woronoff(London Cancer), M. Daoulas(London Cancer), M. Robaszkiewicz(Cancer Registry of Norway), Jacqueline Clavel, Stéphanie Goujon(Cancer Registry of Norway), Brigitte Lacour(Cancer Institute (WIA)), Isabelle Baldi(London Cancer), Camille Pouchieu(Cancer Registry of Norway), Brice Amadéo(Cancer Institute (WIA)), Gaëlle Coureau, Sébastien Orazio, Alain Monnereau, Pierre‐Marie Preux, Faı̈za Rharbaoui(London Cancer), Émilie Marrer(Cancer Registry of Norway), Brigitte Trétarre(London Cancer), Marc Colonna(Cancer Institute (WIA)), Patricia Delafosse, Sandrine Plouvier, Anne Cowppli‐Bony, Florence Molinié, S. Bara(Cancer Institute (WIA)), O. Ganry(Cancer Registry of Norway), B. Lapôtre‐Ledoux(Cancer Institute (WIA)), Pascale Grosclaude(Cancer Institute (WIA)), Nadine Bossard, Zoé Uhry(Cancer Registry of Norway), Jacques Estève(Cancer Institute (WIA)), Roland Stabenow(University College London Hospitals NHS Foundation Trust), Heide Wilsdorf-Köhler, Andrea Eberle, Sabine Luttmann(Cancer Institute (WIA)), I Löhden(London Cancer), Alice Nennecke(Cancer Registry of Norway), Joachim Kieschke(London Cancer), Eunice Sirri(London Cancer), Christina Justenhoven, Sylke Ruth Zeißig(Cancer Registry of Norway), B Holleczek(Cancer Institute (WIA)), Nora Eisemann, Alexander Katalinic(Cancer Institute (WIA)), R.A. Asquez(London Cancer), Vijay Kumar(London Cancer), Eleni Petridou(Cancer Registry of Norway), E J Ólafsdóttir(London Cancer), Laufey Tryggvadóttír(Cancer Institute (WIA)), K.M. Clough-Gorr, Paul M. Walsh(University College London Hospitals NHS Foundation Trust), H Sundseth(Cancer Institute (WIA)), Guido Mazzoleni, Fabio Vittadello(London Cancer), Enzo Coviello, Francesco Cuccaro(Cancer Institute (WIA)), Rocco Galasso(Cancer Institute (WIA)), Giuseppe Sampietro, Adriano Giacomin(London Cancer), Michele Magoni, A Ardizzone, Angelo D’Argenzio(London Cancer), Marine Castaing(Cancer Institute (WIA)), Giuseppe Grosso(London Cancer), Anna Maria Lavecchia, Angela Sardo(Cancer Institute (WIA)), G Gola(London Cancer), Luciana V. Gatti(Cancer Institute (WIA)), Paolo Ricci, Stefano Ferretti(London Cancer), Luigino Dal Maso(London Cancer), Diego Serraino, M V Celesia(Cancer Institute (WIA)), Rosa Angela Filiberti, Fabio Pannozzo, Anna Melcarne, F Quarta, Anita Andreano(Cancer Institute (WIA)), Antonio Russo(Cancer Institute (WIA)), Giuliano Carrozzi(London Cancer), Claudia Cirilli(London Cancer), Luca Cavalieri d’Oro(London Cancer), M Rognoni(London Cancer), Maria Alice Fusco, Maria Francesca Vitale(London Cancer), M. Usala(Cancer Institute (WIA)), Rosanna Cusimano(Cancer Institute (WIA)), Walter Mazzucco(London Cancer), Maria Michiara(Cancer Institute (WIA)), Paolo Sgargi(London Cancer), Lorenza Boschetti(Cancer Institute (WIA)), Giorgio Chiaranda(Cancer Institute (WIA)), Pietro Seghini(Fondazione IRCCS Istituto Nazionale dei Tumori), Milena Maule, Franco Merletti(Cancer Institute (WIA)), Rosario Tumino(Cancer Institute (WIA)), Pamela Mancuso(London Cancer), Massimo Vicentini(Cancer Registry of Norway), Tiziana Cassetti(Cancer Institute (WIA)), Romano Sassatelli, Fabio Falcini, Sabrina Giorgetti(London Cancer), Anna Luisa Caiazzo(Cancer Institute (WIA)), Rossella Cavallo(Cancer Institute (WIA)), R. Cesaraccio, D Pirino, F. Bella, A Madeddu(London Cancer), Anna Clara Fanetti, S. Maspero, Simona Carone, Antonia Mincuzzi(Cancer Institute (WIA)), Giuseppa Candela(Cancer Registry of Norway), T. Scuderi(London Cancer), Maria Gentilini, Silvano Piffer, Stefano Rosso, A Barchielli, Adele Caldarella, Fortunato Bianconi, Fabrizio Stracci(Cancer Institute (WIA)), Paolo Contiero(Cancer Institute (WIA)), Giovanna Tagliabue(London Cancer), Massimo Rugge(London Cancer), Manuel Zorzi, S Beggiato, A Brustolin(Fondazione IRCCS Istituto Nazionale dei Tumori), Gemma Gatta(London Cancer), Massimo Rugge(Cancer Institute (WIA)), Roberta De Angelis(Cancer Institute (WIA)), Roberto Zanetti, A Maurina(London Cancer), M Oniščuka(London Cancer), Seyed Mohsen Mousavi(Cancer Institute (WIA)), N. A. Lipunova(Cancer Institute (WIA)), Ieva Vincerževskienė(London Cancer), D. Agius(Cancer Institute (WIA)), Neville Calleja, Sabine Siesling(Netherlands Comprehensive Cancer Organisation), Otto Visser, Siri Larønningen(Cancer Registry of Norway), Bjørn Møller, Agnieszka Dyzmann-Sroka(London Cancer), Maciej Trojanowski, Stanisław Góźdż(Cancer Registry of Norway), Tomasz Mierzwa(London Cancer), Łucja Molong(Cancer Registry of Norway), Jadwiga Rachtan, Sebastian Szewczyk(Cancer Registry of Norway), Jerzy Błaszczyk(Cancer Institute (WIA)), Kamila Kępska(Cancer Registry of Norway), Beata Kościańska(Cancer Institute (WIA)), R Amunicka, A Ostrowski(London Cancer), M. Zwierko(Cancer Institute (WIA)), Wojciech Kaczmarek, K M Maksimowicz(London Cancer), E Purwin-Porowska(London Cancer), E Reca(Cancer Registry of Norway), J Wójcik-Tomaszewska(London Cancer), E Czajkowska(London Cancer), M Motnyk(London Cancer), Monika Grądalska-Lampart(Cancer Institute (WIA)), A.U. Radziszewska, Anna Gos(London Cancer), Małgorzata Talerczyk(London Cancer), M Wyborska(Cancer Registry of Norway), Joanna Didkowska(Cancer Institute (WIA)), Urszula Wojciechowska(London Cancer), Magdalena Bielska‐Lasota(Cancer Institute (WIA)), G. Forjaz de Lacerda(Cancer Institute (WIA)), R.A. Rego(Cancer Registry of Norway), Branca Carrito, A Pais, M J A T Bento, Jéssica Rodrigues, A. Mayer-da-Silva, A. Miranda(Clínica Girona), Mihaiela L. Blaga(London Cancer), Daniela Coza(Arkhangel'skiy Klinicheskiy Onkologicheskiy Dispanser), М. Yu. Valkov(London Cancer), L Gusenkova(Cancer Institute (WIA)), O Lazarevich(Cancer Institute (WIA)), O Prudnikova, D M Vjushkov(Cancer Institute (WIA)), A. G. Egorova(London Cancer), А Е Орлов(London Cancer), L A Kudyakov(Arkhangel'skiy Klinicheskiy Onkologicheskiy Dispanser), L. V. Pikalova(Cancer Registry of Norway), J Adamcik(London Cancer), C. Safaei Diba(London Cancer), Maja Primic‐Žakelj(London Cancer), Vesna Zadnik(London Cancer), Laís Moraes Gil, A Lopez de Munain, A A Herrera(London Cancer), D Rojas, R J Chillarón, A I M Navarro(Clínica Girona), Rafael Marcos‐Gragera(Clínica Girona), M.L. Vilardell Gil(London Cancer), Esther Molina, M J Sánchez Perez(Cancer Institute (WIA)), P. Franch Sureda(London Cancer), M. Ramos Montserrat, M.D. Chirlaque(London Cancer), Carmen Navarro(London Cancer), Eva Ardanáz(London Cancer), Marcela Guevara, Adela Cañete-Nieto, Rafael Peris‐Bonet(London Cancer), M. Carulla(Cancer Registry of Norway), Jaume Galcerán, Fernando Almela(London Cancer), C Sabater, Saira Khan(London Cancer), David Pettersson(Cancer Institute (WIA)), Paul W. Dickman(Cancer Institute (WIA)), Katharina Staehelin(Cancer Registry of Norway), Benjamin Struchen(London Cancer), Céline Egger Hayoz(London Cancer), Christine Bouchardy(Cancer Institute (WIA)), Robin Schaffar(London Cancer), Matthias Rössle, Seyed Mohsen Mousavi, Jean‐Luc Bulliard(London Cancer), M. Maspoli-Conconi, C. Herrmann, Claudia E. Kuehni, Shelagh Redmond, Andrea Bordoni(London Cancer), Laura Ortelli, Arnaud Chioléro(Cancer Institute (WIA)), Isabelle Konzelmann, Katarina L. Matthes, Sabine Rohrmann(Cancer Registry of Norway), John Broggio(Cancer Registry of Norway), Jem Rashbass(London Cancer), Deirdre Fitzpatrick, Anna Gavin(London Cancer), Donna Clark(Cancer Registry of Norway), A J Deas, D W Huws(London Cancer), Claudia Allemani(University College London Hospitals NHS Foundation Trust), Michel P. Coleman(University College London Hospitals NHS Foundation Trust), V Di Carlo(University College London Hospitals NHS Foundation Trust), Fabio Girardi(University College London Hospitals NHS Foundation Trust), M Matz(Cancer Institute (WIA)), Pamela Minicozzi(London Cancer), Lisa Montel(London Cancer), Maja Nikšić(Cancer Institute (WIA)), Naomi Ssenyonga(Cancer Institute (WIA)), Richard Stephens(Public Health England), Charles Stiller(Public Health England), Elizabeth Chalker(London Cancer), Mark C. Smith(Cancer Institute (WIA)), Richard Walton(Cancer Australia), Hui You(Cancer Australia), Shuting Li, Stephanie Dugdale(Cancer Registry of Norway), Julie Moore, Shoni Philpot(Cancer Institute (WIA)), Ruth M. Pfeiffer(University College London Hospitals NHS Foundation Trust), Helen E. Thomas, B.C. Stokes, Alison Venn(University College London Hospitals NHS Foundation Trust), Helen Farrugia(London Cancer), Vicky Thursfield(Cancer Registry of Norway), J. Dowling(London Cancer), David C. Currow(London Cancer), Christine Fowler(London Cancer), Christopher Lewis
Cited by 38Open Access
Abstract
BACKGROUND: Global variations in survival for brain tumors are very wide when all histological types are considered together. Appraisal of international differences should be informed by the distribution of histology, but little is known beyond Europe and North America. METHODS: The source for the analysis was the CONCORD database, a program of global surveillance of cancer survival trends, which includes the tumor records of individual patients from more than 300 population-based cancer registries. We considered all patients aged 0-99 years who were diagnosed with a primary brain tumor during 2000-2014, whether malignant or nonmalignant. We presented the histology distribution of these tumors, for patients diagnosed during 2000-2004, 2005-2009, and 2010-2014. RESULTS: Records were submitted from 60 countries on 5 continents, 67 331 for children and 671 085 for adults. After exclusion of irrelevant morphology codes, the final study population comprised 60 783 children and 602 112 adults. Only 59 of 60 countries covered in CONCORD-3 were included because none of the Mexican records were eligible. We defined 12 histology groups for children, and 11 for adults. In children (0-14 years), the proportion of low-grade astrocytomas ranged between 6% and 50%. Medulloblastoma was the most common subtype in countries where low-grade astrocytoma was less commonly reported. In adults (15-99 years), the proportion of glioblastomas varied between 9% and 69%. International comparisons were made difficult by wide differences in the proportion of tumors with unspecified histology, which accounted for up to 52% of diagnoses in children and up to 65% in adults. CONCLUSIONS: To our knowledge, this is the first account of the global histology distribution of brain tumors, in children and adults. Our findings provide insights into the practices and the quality of cancer registration worldwide.
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