Leaderboards/Protein Degradation and Inhibitors

Protein Degradation and Inhibitors

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

1
Tomer Tsaban
Hebrew University of Jerusalem
2
Marine Bugnon
SIB Swiss Institute of Bioinformatics
3
Green Ahn
University of Washington
4
Nathaniel J. Henning
Berkeley College
5
Adam D. Cotton
University of California, San Francisco
6
Oliver Hsia
University of Dundee
7
Mengyang Chang
University of Arizona
8
Youmei Xiao
Sun Yat-sen University
9
Nguyen T.B. Nguyen
Heidelberg University
10
Johannes Popow
Boehringer Ingelheim (Austria)

Papers

1
SwissDock 2024: major enhancements for small-molecule docking with Attracting Cavities and AutoDock Vina
Nucleic Acids Research|2024
480 cit.
2
Publication in Nature (2024) [181 citations, W4391994105]
Nature|2024
181 cit.
3
Publication in Science (2024) [158 citations, W4402625837]
Science|2024
158 cit.
4
Lactate controls cancer stemness and plasticity through epigenetic regulation
Cell Metabolism|2025
78 cit.
5
A covalent peptide-based lysosome-targeting protein degradation platform for cancer immunotherapy
Nature Communications|2025
72 cit.
6
Senolysis Enabled by Senescent Cell‐Sensitive Bioorthogonal Tetrazine Ligation
Angewandte Chemie International Edition|2024
45 cit.
7
Selective Elimination of Senescent Cancer Cells by Galacto-Modified PROTACs
Journal of Medicinal Chemistry|2024
33 cit.
8
Senolysis Enabled by Senescent Cell‐Sensitive Bioorthogonal Tetrazine Ligation
Angewandte Chemie|2024
3 cit.
9
Publication in Journal of the American Chemical Society (2026) [2 citations, W7125434031]
Journal of the American Chemical Society|2026
2 cit.
10
Chromosome-level genome assembly and annotation of the spottedtail morwong (Cheilodactylus zonatus)
Scientific Data|2025
0 cit.

Emerging Leaders

Drafting the new consensus

Researchers

1
Eric S. Fischer
Dana-Farber Cancer Institute
2
Alessandra Dall’Agnese
Whitehead Institute for Biomedical Research
3
Deepak Nijhawan
Southwestern Medical Center
4
Stephanie Heinzlmeir
German Cancer Research Center
5
Xiaobao Yang
Beijing Friendship Hospital
6
Jason M. Sheltzer
Yale University
7
Christopher J. Giuliano
IIT@MIT
8
Nicholas Gaskill
The University of Texas Southwestern Medical Center
9
Maria Goralski
The University of Texas Southwestern Medical Center
10
Tinghu Zhang
Stanford University

Papers

1
Oncogene-like addiction to aneuploidy in human cancers
Science|2023
161 cit.
2
Genome-wide identification and analysis of prognostic features in human cancers
Cell Reports|2022
129 cit.
3
Extensive protein dosage compensation in aneuploid human cancers
Genome Research|2022
88 cit.
4
The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance
Nature Communications|2022
47 cit.
5
Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases
Science|2023
46 cit.
6
Unveiling the hidden interactome of CRBN molecular glues
Nature Communications|2025
42 cit.
7
CRISPR-based functional profiling of the Toxoplasma gondii genome during acute murine infection
Nature Microbiology|2024
32 cit.
8
Targeting Proliferating Tumor-Infiltrating Macrophages Facilitates Spatial Redistribution of CD8+ T Cells in Pancreatic Cancer
Cancers|2022
24 cit.
9
Inhibition of a lower potency target drives the anticancer activity of a clinical p38 inhibitor
Cell chemical biology|2023
24 cit.
10
Proteolethargy is a pathogenic mechanism in chronic disease
Cell|2024
24 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

1
C. David Allis
Rockefeller University
2
Craig M. Crews
Yale University
3
Kenneth C. Anderson
Dana-Farber Cancer Institute
4
James E. Bradner
Novartis (China)
5
Jesús F. San Miguel
Clinica Universidad de Navarra
6
Stefan Knapp
Goethe University Frankfurt
7
Nathanael S. Gray
Stanford University
8
Alessio Ciulli
University of Dundee
9
S. Vincent Rajkumar
WinnMed
10
Robin Taylor
Cambridge Crystallographic Data Centre

Papers

1
The language of covalent histone modifications
Nature|2000
8.6k cit.
2
Development and validation of a genetic algorithm for flexible docking 1 1Edited by F. E. Cohen
Journal of Molecular Biology|1997
6.7k cit.
3
International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma
The Lancet Oncology|2014
4.9k cit.
4
New software for searching the Cambridge Structural Database and visualizing crystal structures
Acta Crystallographica Section B Structural Science|2002
3.1k cit.
5
A Phase 2 Study of Bortezomib in Relapsed, Refractory Myeloma
New England Journal of Medicine|2003
2.6k cit.
6
Bortezomib or High-Dose Dexamethasone for Relapsed Multiple Myeloma
New England Journal of Medicine|2005
2.5k cit.
7
Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma
New England Journal of Medicine|2021
2.4k cit.
8
Bortezomib plus Melphalan and Prednisone for Initial Treatment of Multiple Myeloma
New England Journal of Medicine|2008
1.9k cit.
9
Crystallographic evidence for the existence of CH.cntdot..cntdot..cntdot.O, CH.cntdot..cntdot..cntdot.N and CH.cntdot..cntdot..cntdot.Cl hydrogen bonds
Journal of the American Chemical Society|1982
1.9k cit.
10
An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1
Journal of Biological Chemistry|2009
1.8k cit.

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