K

Klaus Rajewsky

Helmholtz Association of German Research Centres

ORCID: 0000-0002-6633-6370

Publishes on T-cell and B-cell Immunology, Immune Cell Function and Interaction, Monoclonal and Polyclonal Antibodies Research. 668 papers and 96.5k citations.

668Publications
96.5kTotal Citations
T-cell and B-cell ImmunologyImmune Cell Function and InteractionMonoclonal and Polyclonal Antibodies ResearchLymphoma Diagnosis and TreatmentImmunotherapy and Immune Responses

Is this you? Claim your profile.

Add your photo, update your bio, and get notified when your ranking changes.

Top publicationsby citations

Inducible Gene Targeting in Mice
Ralf Kühn, Frieder Schwenk, Michel Aguet et al.|Science|1995
Cited by 1.9kOpen Access

A method of gene targeting that allows the inducible inactivation of a target gene in mice is presented. The method uses an interferon-responsive promoter to control the expression of Cre recombinase. Here, Cre was used to delete a segment of the DNA polymerase beta gene flanked by IoxP recombinase recognition sites. Deletion was complete in liver and nearly complete in lymphocytes within a few days, whereas partial deletion was obtained in other tissues. This method can be used for the inducible inactivation of any other gene in vivo.

A New Mouse Myeloma Cell Line that Has Lost Immunoglobulin Expression but Permits the Construction of Antibody-Secreting Hybrid Cell Lines
John F. Kearney, Andreas Radbruch, B Liesegang et al.|The Journal of Immunology|1979
Cited by 1.9kOpen Access

We have isolated a subclone of the mouse myeloma cell line P3-X63-Ag8 that does not express immunoglobulin heavy or light chains. This clone X63-Ag8.653 can be used for efficient fusion with antibody-forming cells to obtain hybrid cell lines producing pure monoclonal antibodies. Screening of hybrid cell lines for specificity and immunoglobulin classes was done with a modified enzyme-linked immunosorbent assay.