Regulation of the Germinal Center Response by MicroRNA-155
To‐Ha Thai(Brigham and Women's Hospital), Dinis Pedro Calado(Brigham and Women's Hospital), Stefano Casola(Brigham and Women's Hospital), K. Mark Ansel(Brigham and Women's Hospital), Changchun Xiao(Brigham and Women's Hospital), Yingzi Xue(Brigham and Women's Hospital), Andrew Murphy(Brigham and Women's Hospital), David Frendewey(Brigham and Women's Hospital), David M. Valenzuela(Brigham and Women's Hospital), Jeffery L. Kutok(Brigham and Women's Hospital), Marc Schmidt‐Supprian(Brigham and Women's Hospital), Nikolaus Rajewsky(Brigham and Women's Hospital), George D. Yancopoulos(Brigham and Women's Hospital), Anjana Rao(Brigham and Women's Hospital), Klaus Rajewsky(Brigham and Women's Hospital)
Cited by 1,474
Abstract
MicroRNAs are small RNA species involved in biological control at multiple levels. Using genetic deletion and transgenic approaches, we show that the evolutionarily conserved microRNA-155 (miR-155) has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell-dependent antibody response. miR-155 exerts this control, at least in part, by regulating cytokine production. These results also suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo.
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