Fiber intake associates with increased treatment response in patients with multiple myeloma along with changes in gut microbiome
Lilli Sophie Sester(German Cancer Research Center), Iuliia Galeeva(University of Tübingen), Juliana de Castilhos(University of Tübingen), Vadim Borisov(University of Tübingen), Anna Katharina Gambihler(Heidelberg University), Michael Kilian(Brigham and Women's Hospital), David Vonhören(University of Mannheim), Mirco Friedrich(Broad Institute), Gernot Poschet(European Molecular Biology Organization), Simon Steiger(German Cancer Research Center), Anna Chechenina(University of Tübingen), Konstanze Lettau(University of Tübingen), Chris Philipp Kohlberger(University of Tübingen), Nina Prokoph(German Cancer Research Center), Jan Hendrik Frenking(German Cancer Research Center), Lukas John(German Cancer Research Center), Stefanie Huhn(Heidelberg University), Philipp Reichert(Heidelberg University), E K(German Cancer Research Center), Karsten Rippe(German Cancer Research Center), Sandra Sauer(Heidelberg University), Carsten Müller-Tidow(Heidelberg University), Niels Weinhold(German Cancer Research Center), M. Platten(University of Mannheim), Hartmut Goldschmidt(Heidelberg University), Marc S. Raab(German Cancer Research Center), Christoph K. Stein-Thoeringer(University of Tübingen)
Cited by 0Open Access
Abstract
Key Points High dietary fiber intake increases gut microbiome diversity and specific fibers link to MRD negativity in NDMM patients. Microbial signatures and butyrate-producing taxa segregate auto-HCT response and may link fiber intake to immune-modulating effects.
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