A non-antibiotic-disrupted gut microbiome is associated with clinical responses to CD19-CAR-T cell cancer immunotherapy

Christoph K. Stein‐Thoeringer; Neeraj Saini; Eli Zamir; Viktoria Blumenberg; Maria‐Luisa Schubert; Uria Mor; Matthias Fante; Sabine Schmidt; Eiko Hayase; Tomo Hayase; Roman Rohrbach; Chia‐Chi Chang; Lauren McDaniel; Ivonne I. Flores; Rogier Gaiser; Matthias Edinger; Daniel Wolff; Martin Heidenreich; Paolo Strati; Ranjit Nair; Dai Chihara; Luis Fayad; Sairah Ahmed; Swaminathan P. Iyer; Raphaël Steiner; Preetesh Jain; Loretta J. Nastoupil; Jason R. Westin; Reetakshi Arora; Michael Wang; Joel G. Turner; Meghan Menges; Melanie J. Hidalgo-Vargas; Kayla Reid; Peter Dreger; Anita Schmitt; Carsten Müller‐Tidow; Frederick L. Locke; Marco L. Davila; Richard E. Champlin; Christopher R. Flowers; Elizabeth J. Shpall; Hendrik Poeck; Sattva S. Neelapu; Michael Schmitt; Marion Subklewe; Michael D. Jain; Robert R. Jenq; Eran Elinav

doi:10.1038/s41591-023-02234-6

A non-antibiotic-disrupted gut microbiome is associated with clinical responses to CD19-CAR-T cell cancer immunotherapy

Christoph K. Stein‐Thoeringer(German Cancer Research Center), Neeraj Saini(The University of Texas MD Anderson Cancer Center), Eli Zamir(German Cancer Research Center), Viktoria Blumenberg(German Cancer Research Center), Maria‐Luisa Schubert(Heidelberg University), Uria Mor(Weizmann Institute of Science), Matthias Fante(University Hospital Regensburg), Sabine Schmidt(German Cancer Research Center), Eiko Hayase(The University of Texas MD Anderson Cancer Center), Tomo Hayase(The University of Texas MD Anderson Cancer Center), Roman Rohrbach(German Cancer Research Center), Chia‐Chi Chang(The University of Texas MD Anderson Cancer Center), Lauren McDaniel(The University of Texas MD Anderson Cancer Center), Ivonne I. Flores(The University of Texas MD Anderson Cancer Center), Rogier Gaiser(German Cancer Research Center), Matthias Edinger(German Cancer Research Center), Daniel Wolff(German Cancer Research Center), Martin Heidenreich(German Cancer Research Center), Paolo Strati(The University of Texas MD Anderson Cancer Center), Ranjit Nair(The University of Texas MD Anderson Cancer Center), Dai Chihara(The University of Texas MD Anderson Cancer Center), Luis Fayad(The University of Texas MD Anderson Cancer Center), Sairah Ahmed(The University of Texas MD Anderson Cancer Center), Swaminathan P. Iyer(The University of Texas MD Anderson Cancer Center), Raphaël Steiner(The University of Texas MD Anderson Cancer Center), Preetesh Jain(The University of Texas MD Anderson Cancer Center), Loretta J. Nastoupil(The University of Texas MD Anderson Cancer Center), Jason R. Westin(The University of Texas MD Anderson Cancer Center), Reetakshi Arora(The University of Texas MD Anderson Cancer Center), Michael Wang(The University of Texas MD Anderson Cancer Center), Joel G. Turner(Moffitt Cancer Center), Meghan Menges(Moffitt Cancer Center), Melanie J. Hidalgo-Vargas(Moffitt Cancer Center), Kayla Reid(Moffitt Cancer Center), Peter Dreger(Heidelberg University), Anita Schmitt(Heidelberg University), Carsten Müller‐Tidow(Heidelberg University), Frederick L. Locke(University of South Florida), Marco L. Davila(University of South Florida), Richard E. Champlin(The University of Texas MD Anderson Cancer Center), Christopher R. Flowers(The University of Texas MD Anderson Cancer Center), Elizabeth J. Shpall(The University of Texas MD Anderson Cancer Center), Hendrik Poeck(German Cancer Research Center), Sattva S. Neelapu(The University of Texas MD Anderson Cancer Center), Michael Schmitt(Heidelberg University), Marion Subklewe(German Cancer Research Center), Michael D. Jain(University of South Florida), Robert R. Jenq(The University of Texas MD Anderson Cancer Center), Eran Elinav(German Cancer Research Center)

Nature Medicine

March 13, 2023

10.1038/s41591-023-02234-6

Cited by 223Open Access

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