Temporal dynamics of the multi-omic response to endurance exercise training
MoTrPAC Study Group, Primary authors, Lead Analysts, David Amar(Stanford University), Nicole R. Gay(Stanford University), Pierre M. Jean Beltran(Broad Institute), Lead Data Generators, Dam Bae(University of Iowa), Surendra Dasari(Mayo Clinic in Florida), Courtney Dennis(Broad Institute), Charles R. Evans(University of Michigan), David A. Gaul(Georgia Institute of Technology), Olga Ilkayeva(Duke University), Anna Ivanova(Emory University), Maureen Kachman(University of Michigan), Hasmik Keshishian(Broad Institute), Ian R. Lanza(Mayo Clinic), Ana C. Lira(University of Iowa), Michael J. Muehlbauer(Duke University), Venugopalan D. Nair(Icahn School of Medicine at Mount Sinai), Paul Piehowski(Pacific Northwest National Laboratory), Jessica L. Rooney(University of Vermont), Kevin S. Smith(Stanford University), Cynthia L. Stowe(Wake Forest University), Bingqing Zhao(Stanford University), Analysts, Natalie M. Clark(Broad Institute), David Jimenez‐Morales(Stanford University), Maléne E. Lindholm(Stanford University), Gina M. Many(Pacific Northwest National Laboratory), James Sanford(Pacific Northwest National Laboratory), Gregory R. Smith(Icahn School of Medicine at Mount Sinai), Nikolai G. Vetr(Stanford University), Tiantian Zhang(Emory University), José Juan Almagro Armenteros(Stanford University), Julián Ávila-Pacheco(Broad Institute), Nasim Bararpour(Stanford University), Yongchao Ge(Icahn School of Medicine at Mount Sinai), Zhenxin Hou(Emory University), Shruti Marwaha(Stanford University), David M. Presby(Joslin Diabetes Center), Archana N. Raja(Stanford University), Evan Savage(Georgia Institute of Technology), Alec Steep(University of Michigan), Yifei Sun(Icahn School of Medicine at Mount Sinai), Si Wu(Stanford University), Jimmy Zhen(Stanford University), Animal Study Leadership, Sue C. Bodine(University of Iowa), Karyn A. Esser(University of Florida), Laurie J. Goodyear(Joslin Diabetes Center), Simon Schenk(University of California San Diego), Manuscript Writing Group Leads, Manuscript Writing Group, Stephen B. Montgomery(Stanford University), Facundo M. Fernández(Georgia Institute of Technology), Stuart C. Sealfon(Icahn School of Medicine at Mount Sinai), M Snyder(Stanford University), Senior Leadership, Joshua Adkins(Pacific Northwest National Laboratory), Euan A. Ashley(Stanford University), Charles Burant(University of Michigan), Steven A. Carr(Broad Institute), Clary B. Clish(Broad Institute), Gary Cutter(University of Alabama at Birmingham), Robert E. Gerszten(Beth Israel Deaconess Medical Center), William E. Kraus(Duke University), Jun Z. Li(University of Michigan), Michael E. Miller(Wake Forest University), K. Sreekumaran Nair(Mayo Clinic in Arizona), Christopher B. Newgard(Duke University), Eric A. Ortlund(Emory University), Weijun Qian(Pacific Northwest National Laboratory), Russell P. Tracy(University of Vermont), Martin J. Walsh(Icahn School of Medicine at Mount Sinai), Matthew T. Wheeler(Stanford University), Co-corresponding Authors, MoTrPAC Study Group, Karen Dalton(Stanford University), Trevor Hastie(Stanford University), Steven G. Hershman(Stanford University), Mihir Samdarshi(Stanford University), Christopher Teng(Stanford University), Rob Tibshirani(Stanford University), Biospecimens Repository, Elaine Cornell(University of Vermont), Nicole Gagne(University of Vermont), Sandy May(University of Vermont), Brian Bouverat(University of Florida), Christiaan Leeuwenburgh(University of Florida), Ching-ju Lu(University of Florida), Marco Pahor(University of Florida), Fang‐Chi Hsu(Wake Forest University), Scott Rushing(Wake Forest University), Michael P. Walkup(Wake Forest University), Exercise Intervention Core, Barbara J. Nicklas(Wake Forest University), W. Jack Rejeski(Wake Forest University), NIH, John P. Williams(National Institutes of Health), Ashley Xia(National Institutes of Health), Brent G. Albertson(Joslin Diabetes Center), Elisabeth R. Barton(University of Florida), Frank W. Booth(University of Missouri), Tiziana Caputo(Joslin Diabetes Center), Michael Z. Cicha(University of Iowa), Luís Gustavo Oliveira de Sousa(University of Iowa), Roger P. Farrar(The University of Texas at Austin), Andrea L. Hevener(University of California, Los Angeles), Michael F. Hirshman(Joslin Diabetes Center), Bailey E. Jackson(University of Iowa), Benjamin G. Ke(University of Virginia), Kyle S. Kramer(University of Iowa), Sarah J. Lessard(Joslin Diabetes Center), Nathan Makarewicz(Joslin Diabetes Center), Andrea G. Marshall(University of Iowa), Pasquale Nigro(Joslin Diabetes Center), Scott K. Powers(Stetson University), Krithika Ramachandran(Joslin Diabetes Center), R. Scott Rector(University of Missouri), Collyn Z-T. Richards(University of Iowa), John P. Thyfault(University of Kansas Medical Center), Zhen Yan(Virginia Cooperative Extension), Chongzhi Zang(University of Virginia), Chemical Analysis Sites, Mary Anne S. Amper(Icahn School of Medicine at Mount Sinai), Ali Tuğrul Balcı(University of Pittsburgh), Clarisa Chavez(Stanford University), Maria Chikina(University of Pittsburgh), Roxanne Chiu(Stanford University), Marina A. Gritsenko(Pacific Northwest National Laboratory), Kristy Guevara(Icahn School of Medicine at Mount Sinai), Joshua Hansen(Pacific Northwest National Laboratory), Krista M. Hennig(Stanford University), Chia-Jui Hung(Stanford University), Chelsea Hutchinson-Bunch(Pacific Northwest National Laboratory), Christopher Jin(Stanford University), Xueyun Liu(Emory University), Kristal Maner-Smith(Emory University), D.R. Mani(Broad Institute), Nada Marjanović(Icahn School of Medicine at Mount Sinai), Matthew Monroe(Pacific Northwest National Laboratory), Ronald Moore(Pacific Northwest National Laboratory), Samuel G. Moore(Georgia Institute of Technology), Charles C. Mundorff(Broad Institute), Daniel Nachun(Stanford University), Michael Nestor(Pacific Northwest National Laboratory), German Nudelman(Icahn School of Medicine at Mount Sinai), Cadence Pearce(Broad Institute), Vladislav Petyuk(Pacific Northwest National Laboratory), Hanna Pinças(Icahn School of Medicine at Mount Sinai), Irene Ramos(Icahn School of Medicine at Mount Sinai), Alexander Raskind, Stas Rirak(Icahn School of Medicine at Mount Sinai), Jeremy Robbins(Beth Israel Deaconess Medical Center), Aliza B. Rubenstein(Icahn School of Medicine at Mount Sinai), Frederique Ruf-Zamojski(Icahn School of Medicine at Mount Sinai), Tyler J. Sagendorf(Pacific Northwest National Laboratory), Nitish Seenarine(Icahn School of Medicine at Mount Sinai), Tanu Soni(University of Michigan), Karan Uppal(Emory University), Sindhu Vangeti(Icahn School of Medicine at Mount Sinai), Mital Vasoya(Icahn School of Medicine at Mount Sinai), Alexandria Vornholt(Icahn School of Medicine at Mount Sinai), Xuechen Yu(Icahn School of Medicine at Mount Sinai), Elena Zaslavsky(Icahn School of Medicine at Mount Sinai), Navid Zebarjadi(Stanford University), Marcas M. Bamman(University of Alabama at Birmingham), Bryan C. Bergman(University of Colorado Anschutz Medical Campus), Daniel H. Bessesen(University of Colorado Anschutz Medical Campus), Thomas W. Buford(University of Alabama at Birmingham), Toby L. Chambers(Ball State University), Paul M. Coen(AdventHealth Orlando), Dan M. Cooper(University of California, Irvine), Fadia Haddad(University of California, Irvine), Kishore M. Gadde(Pennington Biomedical Research Center), Bret H. Goodpaster(AdventHealth Orlando), Melissa Harris(Pennington Biomedical Research Center), Kim M. Huffman(Duke University), Catherine M. Jankowski(University of Colorado Anschutz Medical Campus), Neil M. Johannsen(Pennington Biomedical Research Center), Wendy M. Kohrt(University of Colorado Anschutz Medical Campus), Bridget Lester(Ball State University), Edward L. Melanson(University of Colorado Anschutz Medical Campus), Kerrie L. Moreau(University of Colorado Anschutz Medical Campus), Nicolas Musi(Cedars-Sinai Medical Center), Robert L. Newton(Pennington Biomedical Research Center), Shlomit Radom‐Aizik(University of California, Irvine), Megan E. Ramaker(Duke University), Tuomo Rankinen(Pennington Biomedical Research Center), Blake B. Rasmussen(The University of Texas at San Antonio Health Science Center), Éric Ravussin(Pennington Biomedical Research Center), Irene E. Schauer(University of Colorado Anschutz Medical Campus), Robert S. Schwartz(University of Colorado Anschutz Medical Campus), Lauren M. Sparks(AdventHealth Orlando), Anna Thalacker‐Mercer(University of Alabama at Birmingham), Scott Trappe(Ball State University), Todd A. Trappe(Ball State University), Elena Volpi(The University of Texas at San Antonio Health Science Center)
Cited by 229Open Access
Abstract
profiled the temporal transcriptome, proteome, metabolome, lipidome, phosphoproteome, acetylproteome, ubiquitylproteome, epigenome and immunome in whole blood, plasma and 18 solid tissues in male and female Rattus norvegicus over eight weeks of endurance exercise training. The resulting data compendium encompasses 9,466 assays across 19 tissues, 25 molecular platforms and 4 training time points. Thousands of shared and tissue-specific molecular alterations were identified, with sex differences found in multiple tissues. Temporal multi-omic and multi-tissue analyses revealed expansive biological insights into the adaptive responses to endurance training, including widespread regulation of immune, metabolic, stress response and mitochondrial pathways. Many changes were relevant to human health, including non-alcoholic fatty liver disease, inflammatory bowel disease, cardiovascular health and tissue injury and recovery. The data and analyses presented in this study will serve as valuable resources for understanding and exploring the multi-tissue molecular effects of endurance training and are provided in a public repository ( https://motrpac-data.org/ ).
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