Cited by 454Open Access
Pacific Northwest National Laboratory
ORCID: 0000-0001-7901-5579Publishes on Ionosphere and magnetosphere dynamics, Geophysics and Gravity Measurements, Solar and Space Plasma Dynamics. 8.5k papers and 2.9k citations.
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Quorum sensing peptides produced by commensal skin staphylococci protect against skin injury and inflammation induced by Staphylococcus aureus toxins.
profiled the temporal transcriptome, proteome, metabolome, lipidome, phosphoproteome, acetylproteome, ubiquitylproteome, epigenome and immunome in whole blood, plasma and 18 solid tissues in male and female Rattus norvegicus over eight weeks of endurance exercise training. The resulting data compendium encompasses 9,466 assays across 19 tissues, 25 molecular platforms and 4 training time points. Thousands of shared and tissue-specific molecular alterations were identified, with sex differences found in multiple tissues. Temporal multi-omic and multi-tissue analyses revealed expansive biological insights into the adaptive responses to endurance training, including widespread regulation of immune, metabolic, stress response and mitochondrial pathways. Many changes were relevant to human health, including non-alcoholic fatty liver disease, inflammatory bowel disease, cardiovascular health and tissue injury and recovery. The data and analyses presented in this study will serve as valuable resources for understanding and exploring the multi-tissue molecular effects of endurance training and are provided in a public repository ( https://motrpac-data.org/ ).