Global survival trends for brain tumors, by histology: analysis of individual records for 556,237 adults diagnosed in 59 countries during 2000–2014 (CONCORD-3)
Fabio Girardi(University College London Hospitals NHS Foundation Trust), M Matz(London Cancer), Charles Stiller(Public Health England), Hui You(Cancer Institute of New South Wales), Rafael Marcos Gragera(Clínica Girona), М. Yu. Valkov(Northern State Medical University), Jean‐Luc Bulliard(Centre universitaire de médecine générale et santé publique, Lausanne), Prithwish De, David Morrison(Public Health Scotland), Miriam Wanner(University Hospital of Zurich), David O’Brian(Alaska Department of Health and Social Services), Nathalie Saint‐Jacques(Dalhousie University), Michel P. Coleman(University College London Hospitals NHS Foundation Trust), Claudia Allemani(London Cancer), CONCORD Working Group, S. Bouzbid, M Hamdi-Chérif, L Kara, Kaouel Meguenni, D. Regagba, Saray Mormeneo Bayo, T Cheick Bougadari, S S Manraj, Karima Bendahhou, A Ladipo, Olufemi J. Ogunbiyi, Nontuthuzelo Somdyala, M A Chaplin, Florencia Moreno, G.H. Calabrano, S.B. Espinola, B Carballo Quintero, R Fita, W.D. Laspada, S.G. Ibañez, Carlos Anselmo Lima, Allini Mafra da Costa, P.C.F. De Souza, J. Chaves, C. Laporte, María Paula Curado, J.C. de Oliveira, C.L.A. Veneziano, Donaldo Botelho Veneziano, Ana Beatriz Almeida, M R D O Latorre, Marise Souto Rebelo, M O Santos, G Azevedo e Silva, J.C. Galaz, M Aparicio Aravena, J Sanhueza Monsalve, D.A. Herrmann, S Torres Vargas, Víctor Herrera, Claudia Uribe, Luis Eduardo Bravo, Luz Stella García, Nelson Enrique Arias-Ortiz, D Morantes, Daniel Jurado, María Clara Yépez Chamorro, Sandra Delgado, Melissa Ramirez, Y H Galán Alvarez, Priscila Torres, F Martínez-Reyes, L. Jaramillo, R. Quinto, J Castillo, M Mendoza, Patricia Cueva, J.G. Yépez, Bernard Bhakkan, Jacqueline Deloumeaux, Clarisse Joachim, Jonathan Macni, R Carrillo, J Shalkow Klincovstein, Rebeca Rivera-Gómez, P Pérez, Ebert Poquioma, Guillermo Tortolero‐Luna, Diego Zavala, R. Alonso, Enrique Barrios, Angela Eckstrand, C Nikiforuk, Ryan Woods, Glen Noonan, Donna Turner, Eshwar Kumar, B Zhang, Jeff Dowden, Gregory P. Doyle, Nathalie Saint‐Jacques(Dalhousie University), Gordon Walsh, A Anam, P De, Carol McClure, K.A. Vriends, Claude Bertrand, Agnihotram V. Ramanakumar, Lisa E. Davis, Serena Kozie, T Freeman, J T George, Rosa M. Avila, David K. O’Brien, A Holt, Lyn Almon, Sandy Kwong, Cyllene R. Morris, R Rycroft, Lloyd Mueller, Cathryn Phillips, Heather M. Brown, B Cromartie, Julie J. Ruterbusch, Ann G. Schwartz, G M Levin, Brad Wohler, Rana Bayakly, Kevin C. Ward, Scarlett Lin Gomez, Meg McKinley, Rosemary D. Cress, J M Davis, B. Hernández, Christopher J. Johnson, Bożena M Morawski, Laura Ruppert, Suzanne Bentler, Martin Charlton, Bin Huang, T. C. Tucker, Dennis Deapen, L Liu, Mei‐Chin Hsieh, Xiao‐Cheng Wu, Molly Schwenn, Kimberly J. Stern, S T Gershman, Richard Knowlton, Georgetta Alverson, Timothy D. Weaver, Jay Desai, D B Rogers, J Jackson-Thompson, D Lemons, H J Zimmerman, Michelle M. Hood, J Roberts-Johnson, William A. Hammond, Judy R. Rees, Karen Pawlish, Antoinette M. Stroup, Charles R. Key, Charles L. Wiggins, Amy R. Kahn, Maria J. Schymura, S Radhakrishnan, Chandrika Rao, L K Giljahn, R M Slocumb, C Dabbs, R E Espinoza, K G Aird, T Beran, J J Rubertone, S J Slack, Jae Hwan Oh, T A Janes, Stephen M. Schwartz, S Chiodini, Deborah Hurley, Martin Whiteside, Saroj Rai, Melanie Williams, Kim Herget, Carol Sweeney, Jennifer Kachajian, M B Keitheri Cheteri, Patti Migliore Santiago, S E Blankenship, J L Conaway, R.R. Borchers, R Malicki, J Espinoza, Joseph Grandpre, Hannah K Weir, Reda Wilson, B. K. Edwards, A Mariotto, Carlos Rodríguez‐Galindo, N Wang, Ling Yang, J S Chen, Yan Zhou, Yutong He, G H Song, Xiaoping Gu, Dan Mei, Huijuan Mu, H M Ge, T H Wu, Y Y Li, Di Zhao, F Jin, J H Zhang, F D Zhu, Q Junhua, Y L Yang, C X Jiang, W Biao, J Wang, Q L Li, H Yi, Xin Zhou, Jie Dong, W Li, F X Fu, S Z Liu, Jianguo Chen, Jian Zhu, Y H Li, Yuqiang Lu, Min Fan, Suqin Huang, G P Guo, Hua Zhao-lai, Kuangrong Wei, Weiqiu Chen, Wenqiang Wei, Hongmei Zeng, A Demetriou, W.K. Mang, K.C. Ngan, A.C. Kataki, Manigreeva Krishnatreya, P A Jayalekshmi, P. Sebastian, Preethi Sara George, A. Mathew, A Nandakumar, Reza Malekzadeh, Gholamreza Roshandel, Lital Keinan-Boker, Barbara Silverman, Hidemi Ito, Yuriko N. Koyanagi, M Sato, F Tobori, I Nakata, N Teramoto, Masaya Hattori, Yasuharu Kaizaki, Fumitaka Moki, Hiromi Sugiyama, Mai Utada, M Nishimura, K Yoshida, K Kurosawa, Y Nemoto, Hiroto Narimatsu, Masahiko Sakaguchi, Seiki Kanemura, Michiko Naito, Rintaro Narisawa, Isao Miyashiro, Kayo Nakata, Daisuke Mori, Miwa Yoshitake, Izumi Oki, N Fukushima, Akiko Shibata, K Iwasa, C Ono, Tomohiro Matsuda, Omar Nimri, Kyu‐Won Jung, Young‐Joo Won, Eiman Alawadhi, A Elbasmi, Azizah Ab Manan, Farzaana Adam, E Nansalmaa, Undarmaa Tudev, Chimedsuren Оchir, A M Al Khater, M.M. El Mistiri, G H Lim, Yik Ying Teo, Chun‐Ju Chiang, W C Lee, R Buasom, Suleeporn Sangrajrang, Krittika Suwanrungruang, Patravoot Vatanasapt, Karnchana Daoprasert, Donsuk Pongnikorn, Atit Leklob, S Sangkitipaiboon, Sarayut Lucien Geater, Hutcha Sriplung, O Ceylan, İskender Kög, Oya Dirican, T Köse, T Gurbuz, F E Karaşahin, D Turhan, U Aktaş, Y Halat, Sultan Eser, Cankut Yakut, M Altinisik, Y Cavusoglu, A Türkköylü, N Üçüncü, Monika Hackl, A. Zborovskaya, Olga Aleinikova, K. Henau, Liesbet Van Eycken, T. Atanasov, Z. Valerianova, Mario Šekerija, Ladislav Dušek, Miroslav Zvolský, Lina Steinrud Mørch, Hans H. Storm, Charlotte Wessel Skovlund, Kaire Innos, Margit Mägi, Nea Malila, Karri Seppä, Jérémie Jegu, Michel Velten, Édouard Cornet, Xavier Troussard, Anne‐Marie Bouvier, A.V. Guizard, Véronique Bouvier, Guy Launoy, Sandrine Dabakuyo Yonli, Marie‐Laure Poillot, Marc Maynadié, Morgane Mounier, L Vaconnet, Anne‐Sophie Woronoff, M. Daoulas, Michel Robaszkiewicz, Jacqueline Clavel, Claire Poulalhon, Emmanuel Désandes, Brigitte Lacour, Isabelle Baldi, Brice Amadéo, Gaëlle Coureau, Alain Monnereau, Sébastien Orazio, Michelle Audoin, Tania d’Almeida, Sylvie Boyer, Karima Hammas, Brigitte Trétarre, Marc Colonna, Patricia Delafosse, Sandrine Plouvier, Anne Cowppli‐Bony, Florence Molinié, S. Bara, O. Ganry, B. Lapôtre‐Ledoux, Laëtitia Daubisse‐Marliac, Nadine Bossard, Zoé Uhry, Jacques Estève, Roland Stabenow, Heide Wilsdorf-Köhler, Andrea Eberle, Sabine Luttmann, I Löhden, Alice Nennecke, Joachim Kieschke, Eunice Sirri, Christina Justenhoven, Florian Reinwald, Bernd Holleczek, Nora Eisemann, Alexander Katalinic, R.A. Asquez, Vijay Kumar, Eleni Petridou, E J Ólafsdóttir, Laufey Tryggvadóttír, D E Murray, Paul M. Walsh, H Sundseth, Michael Harney, Guido Mazzoleni, Fabio Vittadello, Enzo Coviello, Francesco Cuccaro, Rocco Galasso, Giuseppe Sampietro, Adriano Giacomin, Michele Magoni, A Ardizzone, Angelo D’Argenzio, Alessia Anna Di Prima, A Ippolito, Anna Maria Lavecchia, A. Sutera Sardo, G Gola, Paola Ballotari, Erica Giacomazzi, Stefano Ferretti, Luigino Dal Maso, Diego Serraino, M V Celesia, Rosa Angela Filiberti, Fabio Pannozzo, Anna Melcarne, F Quarta, Anita Andreano, Antonio Russo, Giuliano Carrozzi, Claudia Cirilli, Luca Cavalieri d’Oro, M Rognoni, Mario Fusco, Maria Francesca Vitale, M. Usala, Rosanna Cusimano, Walter Mazzucco, Maria Michiara, Paolo Sgargi, Lorenza Boschetti, Stefano Marguati, Giorgio Chiaranda, Pietro Seghini, Milena Maule, Franco Merletti, Eugenia Spata, Rosario Tumino, Pamela Mancuso, Tiziana Cassetti, Romano Sassatelli, Fabio Falcini, Sabrina Giorgetti, Anna Luisa Caiazzo, Rossella Cavallo, Daniela Piras, F. Bella, A Madeddu, Anna Clara Fanetti, S. Maspero, Simona Carone, Antonia Mincuzzi, Giuseppa Candela, T. Scuderi, Maria Gentilini, R Rizzello, Stefano Rosso, Adele Caldarella, T. Intrieri, Fortunato Bianconi, Paolo Contiero, Giovanna Tagliabue, Massimo Rugge, Manuel Zorzi, S Beggiato, A Brustolin, Gemma Gatta, Roberta De Angelis, Massimo Vicentini, Roberto Zanetti, Fabrizio Stracci, A Maurina, M Oniščuka, Seyed Mohsen Mousavi, Laura Steponavičienė, Ieva Vincerževskienė, Miriam Azzopardi, Neville Calleja, Sabine Siesling, Otto Visser, Tom Børge Johannesen, Siri Larønningen, Maciej Trojanowski, Paweł Macek, Tomasz Mierzwa, Jadwiga Rachtan, Anna Rosińska, Kamila Kępska, Beata Kościańska, K Barna, Urszula Sulkowska, T. Gebauer, Jadwiga Lapinska, J Wójcik-Tomaszewska, M Motnyk, Ashish Patro, Anna Gos, Karolina Sikorska, Magdalena Bielska‐Lasota, Joanna Didkowska, Urszula Wojciechowska, G. Forjaz de Lacerda, R.A. Rego, Branca Carrito, A Pais, María José Bento, Jéssica Rodrigues, António Lourenço, A. Mayer-da-Silva, Daniela Coza, A.I. Todescu, М. Yu. Valkov(Northern State Medical University), L Gusenkova, O Lazarevich, O Prudnikova, D M Vjushkov, А. И. Егорова, А. В. Орлов, L. V. Pikalova, Л. Д. Жуйкова, J Adamcik, C. Safaei Diba, Vesna Zadnik, Tina Žagar, Marta De-La-Cruz, Arantza López-de-Munain, Araceli Alemán, D Rojas, R J Chillarón, A I M Navarro, Rafael Marcos‐Gragera(Clínica Girona), Montse Puigdemont, Miguel Rodríguez‐Barranco, M J Sánchez Perez, P. Franch Sureda, M. Ramos Montserrat, María Dolores Chirlaque López, A Sánchez Gil, Eva Ardanáz, Marcela Guevara, Adela Cañete-Nieto, Rafael Peris‐Bonet, M. Carulla, Jaume Galcerán, Fernando Almela, C Sabater, S. Khan, David Pettersson, Paul W. Dickman, Katharina Staehelin, Benjamin Struchen, Céline Egger Hayoz, Elisabetta Rapiti, Robin Schaffar, Philip Went, Seyed Mohsen Mousavi, J-L Bulliard(Centre universitaire de médecine générale et santé publique, Lausanne), M. Maspoli-Conconi, Claudia E. Kuehni, S M Redmond, Andrea Bordoni, Laura Ortelli, Arnaud Chioléro, Isabelle Konzelmann, Sabine Rohrmann, Miriam Wanner(University Hospital of Zurich), John Broggio, Jem Rashbass, Charles Stiller(Public Health England), David Fitzpatrick, Anna Gavin, David Morrison(Public Health Scotland), C S Thomson, Giles Greene, D W Huws, Margaret Grayson, H Rawcliffe, Claudia Allemani(London Cancer), Michel P. Coleman(University College London Hospitals NHS Foundation Trust), V Di Carlo, Fabio Girardi(University College London Hospitals NHS Foundation Trust), M Matz(London Cancer), Pamela Minicozzi, Natalia Sanz, Naomi Ssenyonga, David James, Richard Stephens, Elizabeth Chalker, Mark C. Smith, Jessica Gugusheff, Hui You(Cancer Institute of New South Wales), Shuting Li, Stephanie Dugdale, Julie Moore, Shoni Philpot, Ruth M. Pfeiffer, Helen E. Thomas, Bruna S. Ragaini, Alison Venn, Sue Evans, Luc te Marvelde, Valeria Savietto, Richard Trevithick, Joanne F. Aitken, David C. Currow, Christine Fowler, Christopher Lewis
Cited by 67Open Access
Abstract
BACKGROUND: Survival is a key metric of the effectiveness of a health system in managing cancer. We set out to provide a comprehensive examination of worldwide variation and trends in survival from brain tumors in adults, by histology. METHODS: We analyzed individual data for adults (15-99 years) diagnosed with a brain tumor (ICD-O-3 topography code C71) during 2000-2014, regardless of tumor behavior. Data underwent a 3-phase quality control as part of CONCORD-3. We estimated net survival for 11 histology groups, using the unbiased nonparametric Pohar Perme estimator. RESULTS: The study included 556,237 adults. In 2010-2014, the global range in age-standardized 5-year net survival for the most common sub-types was broad: in the range 20%-38% for diffuse and anaplastic astrocytoma, from 4% to 17% for glioblastoma, and between 32% and 69% for oligodendroglioma. For patients with glioblastoma, the largest gains in survival occurred between 2000-2004 and 2005-2009. These improvements were more noticeable among adults diagnosed aged 40-70 years than among younger adults. CONCLUSIONS: To the best of our knowledge, this study provides the largest account to date of global trends in population-based survival for brain tumors by histology in adults. We have highlighted remarkable gains in 5-year survival from glioblastoma since 2005, providing large-scale empirical evidence on the uptake of chemoradiation at population level. Worldwide, survival improvements have been extensive, but some countries still lag behind. Our findings may help clinicians involved in national and international tumor pathway boards to promote initiatives aimed at more extensive implementation of clinical guidelines.
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