450 Increased activity of the ATX/LPA axis diminishes CD8+ T cell cytotoxicity via LPAR5 signaling, driving immune checkpoint blockade resistance in non-small cell lung cancer
Jessica Konen(Emory University), Don L. Gibbons(The University of Texas MD Anderson Cancer Center), Lixia Diao(The University of Texas MD Anderson Cancer Center), Jing Wang(The University of Texas MD Anderson Cancer Center), Haoyi Wu(The University of Texas MD Anderson Cancer Center), Jared J. Fradette(The University of Texas MD Anderson Cancer Center), B. Leticia Rodriguez(The University of Texas MD Anderson Cancer Center)
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