New insights into the genetic etiology of Alzheimer’s disease and related dementias
Céline Bellenguez(Inserm), Fahri Küçükali(University of Antwerp), Iris E. Jansen(Amsterdam Neuroscience), Luca Kleineidam(University of Cologne), Sonia Moreno–Grau(Instituto de Salud Carlos III), Najaf Amin(Erasmus MC), Adam C. Naj(University of Pennsylvania), Rafael Campos-Martín(University of Cologne), Benjamin Grenier‐Boley(Inserm), Víctor Andrade(University of Cologne), Peter Holmans(Cardiff University), Anne Boland(Commissariat à l'Énergie Atomique et aux Énergies Alternatives), Vincent Damotte(Inserm), Sven J. van der Lee(Amsterdam Neuroscience), Marcos R. Costa(Inserm), Teemu Kuulasmaa(University of Eastern Finland), Qiong Yang(Boston University), Itziar de Rojas(Instituto de Salud Carlos III), Joshua C. Bis(University of Washington), Amber Yaqub(Erasmus MC), Ivana Nedeljković(Erasmus MC), Julien Chapuis(Inserm), Shahzad Ahmad(Leiden University Medical Center), Vilmantas Giedraitis(Uppsala University), Dag Aarsland(Stavanger University Hospital), Pablo García‐González(Instituto de Salud Carlos III), Carla Abdelnour(Instituto de Salud Carlos III), Emilio Alarcón‐Martín(Fundació ACE), Daniel Alcolea(Universitat Autònoma de Barcelona), Montserrat Alegret(Instituto de Salud Carlos III), Ignacio Álvarez(University Hospital Mútua de Terrassa), Victoria Álvarez(Instituto de Investigación Biosanitaria de Granada), Nicola J. Armstrong(UNSW Sydney), Anthoula Tsolaki(Aristotle University of Thessaloniki), Carmen Antúnez(Hospital Universitario Virgen de la Arrixaca), Ildebrando Appollonio(Azienda Ospedaliera San Gerardo), Marina Arcaro(Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico), Silvana Archetti(University of Brescia), Alfonso Arias Pastor(Hospital Universitari de Santa Maria), Beatrice Arosio(University of Milan), Lavinia Athanasiu(University of Oslo), Henri Bailly(Université Paris Cité), Nerisa Banaj(Fondazione Santa Lucia), Miquel Baquero(Hospital Universitari i Politècnic La Fe), Sandra Barral(University of Parma), Alexa Beiser(Boston University), Ana Belén Pastor(Hospital Universitari de Santa Maria), Jennifer E. Below(Vanderbilt University), Penelope Benchek(Case Western Reserve University), Luisa Benussi(Centro San Giovanni di Dio Fatebenefratelli), Claudine Berr(Inserm), Céline Besse(Commissariat à l'Énergie Atomique et aux Énergies Alternatives), Valentina Bessi(Azienda Ospedaliero-Universitaria Careggi), Giuliano Binetti(Centro San Giovanni di Dio Fatebenefratelli), Alessandra Bizarro(Agostino Gemelli University Polyclinic), Rafael Blesa(Universitat Autònoma de Barcelona), Merçé Boada(Instituto de Salud Carlos III), Eric Boerwinkle(Baylor College of Medicine), Barbara Borroni(University of Brescia), Silvia Boschi(University of Turin), Paola Bossù(Fondazione Santa Lucia), Geir Bråthen(Norwegian University of Science and Technology), Jan Bressler(The University of Texas Health Science Center at Houston), Catherine Bresner(Cardiff University), Henry Brodaty(UNSW Sydney), Keeley J. Brookes(Nottingham Trent University), Luis Ignacio Brusco(Universidad de Buenos Aires), Dolores Buiza‐Rueda(Instituto de Salud Carlos III), Katharina Bürger(German Center for Neurodegenerative Diseases), Vanessa Burholt(University of Auckland), William S. Bush(Case Western Reserve University), Miguel Calero(Instituto de Salud Carlos III), Laura B. Cantwell(University of Pennsylvania), Geneviève Chêne(Université de Bordeaux), Jaeyoon Chung(Boston University), Michael L. Cuccaro(University of Miami), Ãngel Carracedo(Universidade de Santiago de Compostela), Roberta Cecchetti(University of Perugia), Laura Cervera‐Carles(Universitat Autònoma de Barcelona), Camille Charbonnier(Inserm), Hung‐Hsin Chen(Vanderbilt University), Caterina Chillotti(University of Cagliari), Simona Ciccone(Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico), Jurgen A.H.R. Claassen(Radboud University Nijmegen), Christopher Clark(University of Zurich), Elisa Conti(University of Milano-Bicocca), Anaïs Corma‐Gómez(Hospital Universitario de Valme), Emanuele Maria Costantini(Agostino Gemelli University Polyclinic), Carlo Custodero(University of Bari Aldo Moro), Delphine Daian(Commissariat à l'Énergie Atomique et aux Énergies Alternatives), Carolina Dalmasso(University of Cologne), Antonio Daniele(Agostino Gemelli University Polyclinic), Efthimios Dardiotis(University of Thessaly), Jean‐François Dartigues(Inserm), Peter Paul De Deyn(University Medical Center Groningen), Kátia de Paiva Lopes(Icahn School of Medicine at Mount Sinai), Lot D. de Witte(Icahn School of Medicine at Mount Sinai), Stéphanie Debette(Inserm), Jürgen Deckert, Teodoro del Ser(Fundacion Centro De Investigacion De Enfermedades Neurologicas), Nicola Denning(Cardiff University), Anita L. DeStefano(Boston University), Martin Dichgans(Munich Cluster for Systems Neurology), Janine Diehl‐Schmid(TUM Klinikum), Mónica Díez-Fairén(University Hospital Mútua de Terrassa), Paolo Rossi(Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico), Srdjan Djurovic(University of Oslo), Emmanuelle Duron(Université Paris Cité), Emrah Düzel(German Center for Neurodegenerative Diseases), Carole Dufouil(Université de Bordeaux), Gudny Eiriksdottir(Icelandic Heart Association), Sebastiaan Engelborghs(Vrije Universiteit Brussel), Valentina Escott‐Price(Cardiff University), Ana Espinosa(Instituto de Salud Carlos III), Michael Ewers(German Center for Neurodegenerative Diseases), Kelley M. Faber(Indiana University – Purdue University Indianapolis), Fabrizio Tagliavini(Fondazione IRCCS Istituto Neurologico Carlo Besta), Sune Fallgaard Nielsen(Gentofte Hospital), David W. Fardo(University of Kentucky), Lucia Farotti(University of Perugia), Chiara Fenoglio(University of Milan), Marta Fernández‐Fuertes(Hospital Universitario de Valme), Raffaele Ferrari(Texas Tech University), Catarina B. Ferreira(University of Lisbon), Evelyn Ferri(Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico), Bertrand Fin(Commissariat à l'Énergie Atomique et aux Énergies Alternatives), Peter Fischer(Donauspital), Tormod Fladby(University of Oslo), Klaus Fließbach(University of Cologne), Bernard Fongang(The University of Texas at San Antonio Health Science Center), Myriam Fornage(Norwegian University of Science and Technology), Juan Fortea(Universitat Autònoma de Barcelona), Tatiana M. Foroud(Indiana University – Purdue University Indianapolis), Silvia Fostinelli(Centro San Giovanni di Dio Fatebenefratelli), Nick C. Fox(UK Dementia Research Institute), Emlio Franco-Macías(Instituto de Biomedicina de Sevilla), María J. Bullido(Instituto de Salud Carlos III), Ana Frank(Hospital Universitario La Paz), Lutz Froelich(Heidelberg University), Brian Fulton‐Howard(Icahn School of Medicine at Mount Sinai), Daniela Galimberti(University of Milan), José María García‐Alberca(Instituto de Salud Carlos III), Pablo García‐González(Instituto de Salud Carlos III), Sebastián García‐Madrona(Instituto Ramón y Cajal de Investigación Sanitaria), Guillermo García‐Ribas(Instituto Ramón y Cajal de Investigación Sanitaria), Roberta Ghidoni(Centro San Giovanni di Dio Fatebenefratelli), Ina Giegling(Medical University of Vienna), Giaccone Giorgio(Fondazione IRCCS Istituto Neurologico Carlo Besta), Alison Goate(Icahn School of Medicine at Mount Sinai), Oliver Goldhardt(TUM Klinikum), Duber Gomez-Fonseca(University of Pennsylvania), Antonio González‐Pérez(Centro Andaluz de Biología del Desarrollo), Caroline Graff(Karolinska University Hospital), Giulia Grande(Stockholm University), Emma Green(University of Cambridge), Timo Grimmer(TUM Klinikum), Edna Grünblatt(University of Zurich), Michelle Grunin(Case Western Reserve University), Vilmundur Guðnason(University of Iceland), Tamar Guetta‐Baranes(University of Nottingham), Annakaisa Haapasalo(University of Eastern Finland), Georgios M. Hadjigeorgiou(University of Cyprus), Jonathan L. Haines(Case Western Reserve University), Kara L. Hamilton‐Nelson(University of Miami), Harald Hampel(Sorbonne Université), Olivier Hanon(Université Paris Cité), John Hardy(University College London), Annette M. Hartmann(Medical University of Vienna), Lucrezia Hausner(Heidelberg University), Janet Harwood(Cardiff University), Stefanie Heilmann‐Heimbach(University of Bonn), Seppo Helisalmi(University of Eastern Finland), Michael T. Heneka(University Hospital Bonn), Isabel Hernández(Instituto de Salud Carlos III), Martin J. Herrmann, Per Hoffmann(University of Bonn), Clive Holmes(University of Southampton), Henne Holstege(Amsterdam Neuroscience), Raquel Huerto Vilas(Hospital Universitari de Santa Maria), Marc Hulsman(Amsterdam Neuroscience), Jack Humphrey(Allen Institute for Brain Science), Geert Jan Biessels(University Medical Center Utrecht), Xueqiu Jian(The University of Texas at San Antonio Health Science Center), Charlotte Johansson(Karolinska Institutet), Gyungah Jun(Boston University), Yuriko Kastumata(University of Kentucky), John Kauwe(Brigham Young University), Patrick G. Kehoe(University of Bristol), Lena Kilander(Boston University), Anne Kinhult Ståhlbom(Karolinska Institutet), Miia Kivipelto(University of Eastern Finland), Anne Koivisto(University of Helsinki), Johannes Kornhuber(Friedrich-Alexander-Universität Erlangen-Nürnberg), Mary H. Kosmidis(Aristotle University of Thessaloniki), Walter A. Kukull(University of Washington), Pavel P. Kuksa(University of Pennsylvania), Brian W. Kunkle(University of Cyprus), Amanda Kuzma(University of Pennsylvania), Carmen Lage(Universidad de Cantabria), Erika J. Laukka(Stockholm University), Lenore J. Launer(National Institutes of Health), Alessandra Lauria(Agostino Gemelli University Polyclinic), Chien‐Yueh Lee(University of Pennsylvania), Jenni Lehtisalo(University of Eastern Finland), Ondřej Lerch(Charles University), Alberto Lleó(Universitat Autònoma de Barcelona), W.T. Longstreth(University of Washington), Oscar L. López, Adolfo López de Munain(Instituto de Salud Carlos III), Seth Love(University of Bristol), Malin Löwemark(Boston University), Lauren Luckcuck(Cardiff University), Kathryn L. Lunetta(University of Eastern Finland), Yiyi Ma(Amsterdam University Medical Centers), Juan Macías(Hospital Universitario de Valme), Catherine Macleod(Bangor University), Wolfgang Maier(University Hospital Bonn), Francesca Mangialasche(Karolinska Institutet), Marco Spallazzi(University of Parma), Marta Marquié(Instituto de Salud Carlos III), Iain Marshall(Cardiff University), Eden R. Martin(University of Miami), Ángel Martín Montes(Hospital Universitario La Paz), Carmen Martínez Rodríguez(Instituto de Investigación Biosanitaria de Granada), Carlo Masullo(Università Cattolica del Sacro Cuore), Richard Mayeux(Columbia University), Simon Mead(MRC Prion Unit), Patrizia Mecocci(University of Perugia), Miguel Medina(Instituto de Salud Carlos III), Alun Meggy(Cardiff University), Shima Mehrabian(Medical University of Sofia), Silvia Mendoza, Manuel Menéndez‐González(Instituto de Investigación Biosanitaria de Granada), Pablo Mir(Instituto de Salud Carlos III), Susanne Moebus(University of Duisburg-Essen), Merel O. Mol(Erasmus MC), Laura Molina‐Porcel(Hospital Clínic de Barcelona), Laura Montrreal(Fundació ACE), Laura Morelli(Consejo Nacional de Investigaciones Científicas y Técnicas), Fermín Moreno(Instituto de Salud Carlos III), Kevin Morgan(University of Nottingham), Thomas Mosley(University of Mississippi Medical Center), Markus M. Nöthen(University of Bonn), Carolina Muchnik(Universidad de Buenos Aires), Shubhabrata Mukherjee(University of Washington), Benedetta Nacmias(Don Carlo Gnocchi Foundation), Tiia Ngandu(Finnish Institute for Health and Welfare), Gaël Nicolas(Inserm), Børge G. Nordestgaard(University of Copenhagen), Robert Olaso(Commissariat à l'Énergie Atomique et aux Énergies Alternatives), Adelina Orellana(Instituto de Salud Carlos III), Michela Orsini(Agostino Gemelli University Polyclinic), Gemma Ortega(Instituto de Salud Carlos III), Alessandro Padovani(Baylor College of Medicine), Paolo Caffarra(University of Parma), Goran Papenberg(Stockholm University), Lucilla Parnetti(University of Perugia), Florence Pasquier(Inserm), Pau Pástor(University Hospital Mútua de Terrassa), Gina M. Peloso(Boston University), Alba Pérez‐Cordón(Fundació ACE), Jordi Pérez‐Tur(Instituto de Salud Carlos III), Pierre Péricard(Centre National de la Recherche Scientifique), Oliver Peters(German Center for Neurodegenerative Diseases), Yolande A.L. Pijnenburg(Amsterdam Neuroscience), Juan A. Pineda(Hospital Universitario de Valme), Gerard Piñol-Ripoll(Hospital Universitari de Santa Maria), Claudia Pisanu(University of Cagliari), Thomas Polak, Julius Popp(University Hospital of Zurich), Daniëlle Posthuma(Amsterdam Neuroscience), Josef Priller(German Center for Neurodegenerative Diseases), Raquel Puerta(Fundació ACE), Olivier Quenez(Inserm), Inés Quintela(Universidade de Santiago de Compostela), Jesper Qvist Thomassen(Rigshospitalet), Alberto Rábano(Instituto de Salud Carlos III), Innocenzo Rainero(University of Brescia), Farid Rajabli(University of Miami), Inez Ramakers(Maastricht University), Luís Miguel Real(Hospital Universitario de Valme), Marcel Reinders(Delft University of Technology), Christiane Reitz(Columbia University), Dolly Reyes‐Dumeyer(Columbia University), Perry Ridge(Brigham Young University), Steffi G. Riedel‐Heller(Leipzig University), Peter Riederer(Universitätsklinikum Würzburg), Natalia Roberto(Fundació ACE), Eloy Rodríguez‐Rodríguez(Universidad de Cantabria), Arvid Rongve(Privatsykehuset Haugesund), Irene Rosas Allende(Instituto de Investigación Biosanitaria de Granada), Maitée Rosende-Roca(Instituto de Salud Carlos III), José Luís Royo(Universidad de Málaga), Elisa Rubino(Azienda Ospedaliera Citta' della Salute e della Scienza di Torino), Dan Rujescu(Medical University of Vienna), María Eugenia Sáez(Centro Andaluz de Biología del Desarrollo), Paraskevi Sakka(Greek Association of Alzheimer's Disease and Related Disorders), Ingvild Saltvedt(St Olav's University Hospital), Ángela Sanabria(Instituto de Salud Carlos III), María Bernal Sánchez‐Arjona(Instituto de Biomedicina de Sevilla), Florentino Sánchez-García(Hospital Universitario de Gran Canaria Doctor Negrín), Pascual Sánchez‐Juan(Universidad de Cantabria), Raquel Sánchez‐Valle(Consorci Institut D'Investigacions Biomediques August Pi I Sunyer), Sigrid B. Sando(St Olav's University Hospital), Chloé Sarnowski(The University of Texas Health Science Center at Houston), Claudia L. Satizábal(Boston University), Michela Scamosci(University of Perugia), Nikolaos Scarmeas(National and Kapodistrian University of Athens), Elio Scarpini(University of Milan), Philip Scheltens(Amsterdam Neuroscience), Norbert Scherbaum(University of Duisburg-Essen), Martin Scherer(Universität Hamburg), Matthias Schmid(University Hospital Bonn), Anja Schneider(University Hospital Bonn), Jonathan M. Schott(UK Dementia Research Institute), Geir Selbæk(Oslo University Hospital), Davide Seripa(Ospedale Vito Fazzi), Manuel Serrano‐Ríos(Hospital Clínico San Carlos), Jin Sha(University of Pennsylvania), Alexey Shadrin(University of Oslo), Olivia Anna Skrobot(University of Bristol), Susan Slifer(University of Miami), Gijsje J. L. Snijders(Icahn School of Medicine at Mount Sinai), Hilkka Soininen(University of Eastern Finland), Vincenzo Solfrizzi(University of Bari Aldo Moro), Alina Solomon(University of Eastern Finland), Yeunjoo E. Song(Case Western Reserve University), Sandro Sorbi(Don Carlo Gnocchi Foundation), Óscar Sotolongo‐Grau(Fundació ACE), Gianfranco Spalletta(Fondazione Santa Lucia), Annika Spottke(University of Bonn), Alessio Squassina(University of Cagliari), Eystein Stordal(Namsos Hospital), Juan Pablo Tartan(Fundació ACE), Lluís Tárraga(Instituto de Salud Carlos III), Niccoló Tesi(Amsterdam Neuroscience), Anbupalam Thalamuthu(UNSW Sydney), Thomas Tegos(Aristotle University of Thessaloniki), Giuseppe Tosto(Columbia University), Latchezar Traykov(Medical University of Sofia), Lucio Tremolizzo(Azienda Ospedaliera San Gerardo), Anne Tybjærg-Hansen(University of Copenhagen), André G. Uitterlinden(Erasmus MC), Abbe Ullgren(Karolinska Institutet), Ingun Ulstein(Oslo University Hospital), Sergi Valero(Instituto de Salud Carlos III), Otto Valladares(University of Pennsylvania), Christine Van Broeckhoven(VIB-UAntwerp Center for Molecular Neurology), Jeffery M. Vance(University of Miami), Badri N. Vardarajan(Columbia University), Aad van der Lugt(Erasmus MC), Jasper Van Dongen(University of Antwerp), Jeroen van Rooij(Erasmus MC), John C. van Swieten(Erasmus MC), Rik Vandenberghe(KU Leuven), Frans Verhey(Maastricht University), Jean‐Sébastien Vidal(Université Paris Cité), Jonathan Vogelgsang(Harvard University), Martin Vyhnálek(Charles University), Michael Wagner(University Hospital Bonn), David Wallon(Inserm), Li-San Wang(University of Pennsylvania), Ruiqi Wang(Boston University), Leonie Weinhold(University Hospital Bonn), Jens Wiltfang(German Center for Neurodegenerative Diseases), Gill Windle(Bangor University), Bob Woods(Bangor University), Mary Yannakoulia(Harokopio University of Athens), Habil Zare(The University of Texas at San Antonio Health Science Center), Yi Zhao(Fondazione Santa Lucia), Xiaoling Zhang(Boston University), Congcong Zhu(Boston University), Miren Zulaica(Instituto de Salud Carlos III), EADB(Charles University), Jan Laczó(Na Homolce Hospital), Václav Maťoška(University of Milan), María Serpente(Fondazione Santa Lucia), Francesca Assogna(Fondazione Santa Lucia), Fabrizio Piras(Fondazione Santa Lucia), Federica Piras(Fondazione Santa Lucia), Valentina Ciullo(Fondazione Santa Lucia), Jacob Shofany(Azienda Ospedaliera San Gerardo), Carlo Ferrarese(University of Milano-Bicocca), Simona Andreoni(University of Milano-Bicocca), Gessica Sala(University of Milano-Bicocca), Chiara Paola Zoia(University of Cagliari), Maria Del Zompo(University of Brescia), Alberto Benussi(University of Perugia), Patrizia Bastiani(University of Eastern Finland), Mari Takalo(University of Eastern Finland), Teemu Natunen(University of Eastern Finland), Tiina Laatikainen(University of Eastern Finland), Jaakko Tuomilehto(University of Oulu), Riitta Antikainen(University of Oulu), Timo Strandberg(Finnish Institute for Health and Welfare), Jaana Lindström(Finnish Institute for Health and Welfare), Markku Peltonen(Cardiff University), Richard Abraham(King's College London), Ammar Al‐Chalabi(University College London), Nicholas J. Bass(University of Cambridge), Carol Brayne(University of Nottingham), Kristelle S. Brown(MRC Prion Unit), John Collinge(Queen's University Belfast), David Craig(Wellcome Sanger Institute), Pangiotis Deloukas(UK Dementia Research Institute), Nick C. Fox(UK Dementia Research Institute), Amy Gerrish(St. James's Hospital), Michael Gill(Wellcome Sanger Institute), Rhian Gwilliam(Dublin City University), Denise Harold(Cardiff University), Paul Hollingworth(Queen's University Belfast), Jarret A. Johnston(Cardiff University), Lesley Jones(St. James's Hospital), Brian Lawlor(University College London), Gill Livingston(University of Oxford), Simon Lovestone(King's College London), Michelle K. Lupton(St. James's Hospital), Aoibhinn Lynch(Manchester Academic Health Science Centre), David Mann(Queen's University Belfast), Bernadette McGuinness(University College London), Andrew McQuillin(Cardiff University), Michael O‘Donovan(Cardiff University), Michael J. Owen(King's College London), Peter Passmore(King's College London), John Powell(Universitat Autònoma de Barcelona), Petra Proitsi(King's College London), Martin Rossor(John Radcliffe Hospital), Christopher E. Shaw(University College London), A. David Smith(Queen's University Belfast), H. Gurling(UK Dementia Research Institute), Stephen Todd(UK Dementia Research Institute), Catherine J. Mummery(Agostino Gemelli University Polyclinic), Nathalie Ryan(Instituto de Salud Carlos III), Giordano Lacidogna(Fundació ACE), Ad Adarmes-Gómez(Fundació ACE), Ana Mauleón(Fundació ACE), Ana Pancho(Fundació ACE), A. Gailhajenet(Instituto de Salud Carlos III), Asunción Lafuente(Fundació ACE), Daniel Macías‐García(Fundació ACE), Elvira Martín(University of Miami), Esther Pelejà(Centro de Biología Molecular Severo Ochoa), F. Carrillo(Instituto de Salud Carlos III), Isabel Sastre Merlín(Fundació ACE), L. Garrote-Espina(Instituto de Salud Carlos III), Liliana Vargas(Instituto de Biomedicina de Sevilla), Mario Carrión‐Claro(Instituto de Salud Carlos III), M. Marín(Fundació ACE), Ma Labrador(Hospital Clínico Universitario de Valencia), Mar Buendía(Fundació ACE), M. D. Alonso(Fundació ACE), Marina Guitart(Fundació ACE), Mariona Moreno(Instituto de Salud Carlos III), Marta Ibarria(Instituto de Salud Carlos III), Mt Periñán(Instituto de Salud Carlos III), Núria Aguilera(Instituto de Salud Carlos III), Pilar Gómez‐Garre(Instituto de Salud Carlos III), Pilar Cañabate(Instituto de Biomedicina de Sevilla), R. Escuela(Erasmus MC), Rocío Pineda-Sánchez(Instituto de Salud Carlos III), R. Vigo-Ortega(Fundació ACE), Silvia Jesús(Instituto de Biomedicina de Sevilla), Sílvia Preckler(Fundació ACE), Silvia Rodrigo‐Herrero(University of Turin), Susana Diego(University of Turin), Alessandro Vacca, Fausto Roveta, Nicola Salvadori(University Hospital Bonn), Elena Chipi(German Center for Neurodegenerative Diseases), Henning Boecker, Christoph Laske(Harokopio University of Athens), Robert Perneczky(Ludwig-Maximilians-Universität München), Costas A. Anastasiou(Ludwig-Maximilians-Universität München), Daniel Janowitz(Aristotle University of Thessaloniki), Rainer Malik(University Hospital Bonn), Anna Anastasiou(Universidad de Cantabria), Kayenat Parveen(Universidad de Cantabria), Carmen Lage(Universidad de Cantabria), Sara López‐García(Medical University of Sofia), Anna Antonell(Medical University of Sofia), Kalina Mihova(Universitätsklinikum Würzburg), Diyana Belezhanska(Consejo Nacional de Investigaciones Científicas y Técnicas), Heike Weber(Consejo Nacional de Investigaciones Científicas y Técnicas), Silvia Kochen(Consejo Nacional de Investigaciones Científicas y Técnicas), Patricia Solís(Consejo Nacional de Investigaciones Científicas y Técnicas), Nancy Medel(Consejo Nacional de Investigaciones Científicas y Técnicas), Julieta Lisso(Consejo Nacional de Investigaciones Científicas y Técnicas), Zulma Sevillano(Consejo Nacional de Investigaciones Científicas y Técnicas), Daniel G. Politis(Consejo Nacional de Investigaciones Científicas y Técnicas), Valeria Cores, Carolina Cuesta, Cecilia Ortiz, Juan Ignacio Bacha, Mario Rios(Universidad Nacional de La Pampa), Aldo Saenz, Mariana Sanchez Abalos, Eduardo Köhler, Dana Lis Palacio, Ignacio Etchepareborda(Instituto de Neurología Cognitiva), Matias Köhler(Instituto de Neurología Cognitiva), Gisela V. Novack(Instituto de Neurología Cognitiva), Federico Ariel Prestia(Instituto de Neurología Cognitiva), Pablo Galeano(Universidad de Buenos Aires), Eduardo M. Castaño(Universidad de Buenos Aires), Sandra Germani(Universidad de Buenos Aires), Carlos Reyes Toso(Universidad de Buenos Aires), Matias Rojo(Universidad de Buenos Aires), Carlos A. Ingino(University of Cambridge), Carlos Mangone(German Center for Neurodegenerative Diseases), David C. Rubinsztein(Inserm), Stefan Teipel(Inserm), Nathalie Fiévet(Karolinska University Hospital), Vincent Deramerourt(Karolinska University Hospital), Charlotte Forsell(Universidade de Santiago de Compostela), Håkan Thonberg(Universidade de Santiago de Compostela), Maria Bjerke(Hospital Clínico San Carlos), Ellen De Roeck(Universidad de Buenos Aires), Nicholas G. Martin(Instituto de Salud Carlos III), Natividad Olivar(Fundació ACE), GR@ACE(Instituto de Salud Carlos III), Núria Aguilera(Hospital Universitario de Valme), Amanda Cano(Universidade de Santiago de Compostela), Pilar Cañabate(Fundació ACE), Juan Macías(Fundació ACE), Olalla Maroñas(Fundació ACE), Raúl Núñez‐Llaves(Instituto de Salud Carlos III), Clàudia Olivé(Hospital Clínico Universitario de Valencia), E. Pelejà(Hospital Universitario Son Espases), DEGESCO(Hospital Universitario Virgen de la Arrixaca), Astrid D. Adarmes-Gómez(Hospital Universitari i Politècnic La Fe), M. D. Alonso(Instituto de Salud Carlos III), Guillermo Amer-Ferrer(Instituto de Salud Carlos III), Martirio Antequera(Instituto Ramón y Cajal de Investigación Sanitaria), J A Burguera(University of the Basque Country), Fátima Carrillo(Instituto de Salud Carlos III), Mario Carrión‐Claro(Instituto de Salud Carlos III), M. J. Casajeros(Instituto de Salud Carlos III), Marian M. de Pancorbo, R. Escuela(Instituto de Salud Carlos III), L. Garrote-Espina(Instituto de Salud Carlos III), Pilar Gómez‐Garre(Hospital Universitario Virgen de la Arrixaca), S. Hevilla(Universidad de Cantabria), Silvia Jesús(Instituto de Salud Carlos III), M. A. Labrador Espinosa(Hospital Universitario Son Espases), Agustina Legaz(Instituto de Biomedicina de Sevilla), Sara López‐García(Hospital Universitario Virgen de la Arrixaca), Daniel Macías‐García, Salvadora Manzanares(Hospital Universitario Virgen de la Arrixaca), Marta Marín‐Oto(Hospital Universitario Virgen de la Arrixaca), Juan Marín-Muñoz(Fundacion CITA Alzheimer), Tamara Marín(Navarrabiomed), Begoña Martínez(Instituto de Salud Carlos III), Victoriana Martínez(Instituto de Biomedicina de Sevilla), Pablo Martínez-Lage Álvarez(Hospital Universitario de La Princesa), Maite Mendioroz Iriarte(Instituto de Biomedicina de Sevilla), María Teresa Periñán-Tocino(Centro de Biología Molecular Severo Ochoa), Rocío Pineda-Sánchez(Hospital Universitario Virgen de la Arrixaca), Diego Real de Asúa(Instituto de Salud Carlos III), Silvia Rodrigo(Hospital Universitario Virgen de la Arrixaca), I. Sastre(Centre National de la Recherche Scientifique), M.P. Vicente(Inserm), R. Vigo-Ortega(Inserm), Liliana Vivancos(Inserm), EADI(Inserm), Jacques Epelbaum(Centre National de la Recherche Scientifique), Didier Hannequin(Sorbonne Université), Dominique Campion(Cardiff University), Vincent Deramecourt(Cardiff University), Christophe Tzourio(Cardiff University), Alexis Brice(Cardiff University), Bruno Dubois(Cardiff University), GERAD(Cardiff University), Amy L. Williams(Cardiff University), Charlene Thomas(University of Nottingham), Chloe Davies(University of Nottingham), Will Nash(University of Nottingham), Kimberley Dowzell(Newcastle Hospitals - Campus for Ageing and Vitality), Atahualpa Castillo-Morales(University College London), Mateus Bernardo-Harrington(University College London), James Turton(UK Dementia Research Institute), Jenny Lord(UK Dementia Research Institute), Kristelle S. Brown(University College London), Emma Vardy(MRC Prion Unit), Elizabeth Fisher(University College London), Jason D. Warren(King's College London), Martin Rossor(University of Bonn), Natalie S. Ryan(University of Bonn), Rita Guerreiro(German Center for Neurodegenerative Diseases), James Uphill(German Center for Neurodegenerative Diseases), Nick Bass(Queen's University Belfast), Reinhard Heun(Queen's University Belfast), Heike Kölsch(King's College London), Britta Schürmann(King's College London), André Lacour(King's College London), Christine Herold(University of Bonn), Janet Johnston(John Radcliffe Hospital), Peter Passmore(John Radcliffe Hospital), John Powell(University College London), Yogen Patel(Wellcome Sanger Institute), Angela Hodges(University of Bristol), Tim Becker(Manchester Academic Health Science Centre), Donald Warden(Manchester Academic Health Science Centre), Gordon Wilcock(University of Southampton), Robert Clarke(Somerset Partnership NHS Foundation Trust), Panagiotis Deloukas(University Hospital of Wales), Yoav Ben‐Shlomo(Charité - Universitätsmedizin Berlin), Nigel M. Hooper(University of Cologne), Stuart Pickering‐Brown(Helmholtz Zentrum München), Rebecca Sussams(Saarland University), Nick Warner(Saarland University), Anthony Bayer(Saarland University), Isabella Heuser(Saarland University), Dmitriy Drichel(Saarland University), Norman Klopp(Universität Hamburg), Manuel Mayhaus(University of Freiburg), Matthias Riemenschneider(Heidelberg University), Sabrina Pinchler(Helmholtz Zentrum München), Thomas Feulner(University of Duisburg-Essen), Wei Gu(Cardiff University), Hendrik van den Bussche(Cardiff University), Michael Hüll(Oslo University Hospital), Lutz Frölich(Norwegian University of Science and Technology), H-Erich Wichmann(Akershus University Hospital), Karl‐Heinz Jöckel(Innlandet Hospital Trust), Michael O‘Donovan(University of Helsinki), Michael J. Owen(University of Helsinki), Demgene(AbbVie (United States)), Shahram Bahrami(AstraZeneca (United Kingdom)), Ingunn Bosnes(Biogen (United States)), Per Selnes(Biogen (United States)), Sverre Bergh, FinnGen, Aarno Palotie, Mark J. Daly(GlaxoSmithKline (United Kingdom)), Howard J. Jacob(GlaxoSmithKline (United Kingdom)), Athena Matakidou(Merck & Co., Inc., Rahway, NJ, USA (United States)), Heiko Runz(Pfizer (United States)), Sally John(Sanofi (France)), Robert M. Plenge(Sanofi (France)), Mark McCarthy(Maze (United States)), Julie Hunkapiller(Janssen (Belgium)), Meg Ehm(University of Helsinki), Dawn Waterworth(University of Helsinki), Caroline S. Fox(University of Turku), Anders Mälarstig(University of Turku), Kathy Klinger(Finnish Institute for Health and Welfare), Kathy Call(Finnish Institute for Health and Welfare), Timothy E.J. Behrens(Finnish Red Cross), Patrick Loerch(Hospital District of Helsinki and Uusimaa), Tomi P. Mäkelä(Borealis (Finland)), Jaakko Kaprio(Borealis (Finland)), Petri Virolainen(Borealis (Finland)), Kari Pulkki(Borealis (Finland)), Terhi Kilpi(University of Oxford), Markus Perola(Tampere University), Jukka Partanen(University of Eastern Finland), Anne Pitkäranta(Central Finland Health Care District), Riitta Kaarteenaho(Business Finland), Seppo Vainio(Business Finland), Miia Turpeinen(Business Finland), Raisa Serpi(AbbVie (United States)), Tarja Laitinen(AbbVie (United States)), Johanna Mäkelä(Biogen (United States)), Veli‐Matti Kosma, Urho M. Kujala(Merck & Co., Inc., Rahway, NJ, USA (United States)), Outi Tuovila(Pfizer (United States)), Minna Hendolin(Pfizer (United States)), Raimo Pakkanen(Sanofi (France)), Jeff Waring(Maze (United States)), Bridget Riley‐Gillis(Janssen (Belgium)), Jimmy Liu(University of Helsinki), Shameek Biswas(University of Turku), Dorothée Diogo(Finnish Red Cross), Catherine Marshall(Hospital District of Helsinki and Uusimaa), Xinli Hu(Borealis (Finland)), Matthias Gossel(Borealis (Finland)), Robert Graham(University of Eastern Finland), Beryl B. Cummings(Central Finland Health Care District), Samuli Ripatti, Johanna Schleutker, Mikko Arvas, Olli Carpén(Pirkanmaa Hospital District), Reetta Hinttala(Hospital District of Helsinki and Uusimaa), Johannes Kettunen(Varsinais-Suomen Sairaanhoitopiiri), Arto Mannermaa(AbbVie (United States)), Jari Laukkanen(AbbVie (United States)), Valtteri Julkunen(AbbVie (United States)), Anne M. Remes(AbbVie (United States)), Reetta Kälviäinen(AbbVie (United States)), Jukka Peltola(Biogen (United States)), Pentti Tienari(Biogen (United States)), Juha O. Rinne, Adam Ziemann, Jeffrey F. Waring, Sahar Esmaeeli, Nizar Smaoui, Anne Lehtonen, Susan Eaton(Merck & Co., Inc., Rahway, NJ, USA (United States)), Sanni Lahdenperä(Merck & Co., Inc., Rahway, NJ, USA (United States)), Janet van Adelsberg(Pfizer (United States)), John A. Michon(Pfizer (United States)), Geoff Kerchner(GlaxoSmithKline (United Kingdom)), Natalie Bowers(GlaxoSmithKline (United Kingdom)), Edmond Teng(Hospital District of Helsinki and Uusimaa), John D. Eicher(Hospital District of Helsinki and Uusimaa), Vinay Mehta(Pirkanmaa Hospital District), Padhraig Gormley(Northern Ostrobothnia Hospital District), Kari Linden, Christopher D. Whelan(Varsinais-Suomen Sairaanhoitopiiri), Fanli Xu(AbbVie (United States)), David Pulford(AbbVie (United States)), Martti Färkkilâ(AbbVie (United States)), Sampsa Pikkarainen, Airi Jussila(Amsterdam Neuroscience), Timo Blomster, Mikko Kiviniemi(Pfizer (United States)), Markku Voutilainen(Pfizer (United States)), Bob Georgantas(GlaxoSmithKline (United Kingdom)), Graham Heap(Hospital District of Helsinki and Uusimaa), Fedik Rahimov(Varsinais-Suomen Sairaanhoitopiiri), Keith Usiskin(Pirkanmaa Hospital District), Tim Lu(Varsinais-Suomen Sairaanhoitopiiri), Danny Oh, Kirsi Kalpala(Northern Ostrobothnia Hospital District), Melissa Miller(AbbVie (United States)), Linda McCarthy, Kari K. Eklund(Pfizer (United States)), Antti Palomäki(GlaxoSmithKline (United Kingdom)), Pia Isomäki(University of Helsinki), Laura Pirilä, Oili Kaipiainen‐Seppänen(Hospital District of Helsinki and Uusimaa), Johanna Huhtakangas(Pirkanmaa Hospital District), Apinya Lertratanakul(Northern Ostrobothnia Hospital District), Marla Hochfeld(AstraZeneca (United Kingdom)), Nan Bing, Jorge Esparza Gordillo, Nina Mars(GlaxoSmithKline (United Kingdom)), Margit Pelkonen(GlaxoSmithKline (United Kingdom)), Paula Kauppi(Finnish Institute for Health and Welfare), Hannu Kankaanranta(Finnish Institute for Health and Welfare), Terttu Harju(Varsinais-Suomen Sairaanhoitopiiri), David A. Close(Varsinais-Suomen Sairaanhoitopiiri), Steven M. Greenberg(Pirkanmaa Hospital District), Hubert Chen(Vanderbilt University), Jo Betts, Soumitra Ghosh, Veikko Salomaa(Hospital District of Helsinki and Uusimaa), Teemu Niiranen(Hospital District of Helsinki and Uusimaa), Markus Juonala(Hospital District of Helsinki and Uusimaa), Kaj Metsärinne(AstraZeneca (United Kingdom)), Mika Kähönen, Juhani Junttila(Merck & Co., Inc., Rahway, NJ, USA (United States)), Markku Laakso(Pfizer (United States)), Jussi Pihlajamäki(Sanofi (France)), Juha Sinisalo(Hospital District of Helsinki and Uusimaa), Marja‐Riitta Taskinen(Hospital District of Helsinki and Uusimaa), Tiinamaija Tuomi(Hospital District of Helsinki and Uusimaa), Ben Challis(Hospital District of Helsinki and Uusimaa), Andrew S. Peterson(Pirkanmaa Hospital District), Audrey Y. Chu(Northern Ostrobothnia Hospital District), Jaakko Parkkinen(Northern Ostrobothnia Hospital District), Anthony J. Muslin(Northern Ostrobothnia Hospital District), Heikki Joensuu(Varsinais-Suomen Sairaanhoitopiiri), Tuomo J Meretoja(AbbVie (United States)), Lauri A. Aaltonen, Johanna Mattson(Merck & Co., Inc., Rahway, NJ, USA (United States)), Annika Auranen(Merck & Co., Inc., Rahway, NJ, USA (United States)), Peeter Karihtala(Pfizer (United States)), Saila Kauppila(Pfizer (United States)), Päivi Auvinen(Sanofi (France)), Klaus Elenius(GlaxoSmithKline (United Kingdom)), Relja Popovic, Jennifer L. Schutzman(Hospital District of Helsinki and Uusimaa), Andrey Loboda(Hospital District of Helsinki and Uusimaa), Aparna Chhibber(Hospital District of Helsinki and Uusimaa), Heli Lehtonen(Pirkanmaa Hospital District), Stefan McDonough(Varsinais-Suomen Sairaanhoitopiiri), Marika Crohns(Pirkanmaa Hospital District), Diptee Kulkarni(Northern Ostrobothnia Hospital District), Kai Kaarniranta(Northern Ostrobothnia Hospital District), Joni A. Turunen(Biogen (United States)), Terhi Ollila, Sanna Seitsonen, Hannu Uusitalo(Merck & Co., Inc., Rahway, NJ, USA (United States)), Vesa Aaltonen(GlaxoSmithKline (United Kingdom)), Hannele Uusitalo‐Järvinen(Northern Ostrobothnia Hospital District), Marja Luodonpää(Northern Ostrobothnia Hospital District), Nina Hautala(Hospital District of Helsinki and Uusimaa), Stephanie Loomis(Pirkanmaa Hospital District), Erich C. Strauss(Hospital District of Helsinki and Uusimaa), Hao Chen(Vanderbilt University), Anna Podgornaia, Joshua Hoffman(German Center for Neurodegenerative Diseases), Kaisa Tasanen, Laura Huilaja(Hospital District of Helsinki and Uusimaa), Katariina Hannula‐Jouppi(Hospital District of Helsinki and Uusimaa), Teea Salmi(Hospital District of Helsinki and Uusimaa), Sirkku Peltonen(Hospital District of Helsinki and Uusimaa), Leena Koulu(Hospital District of Helsinki and Uusimaa), Ilkka T. Harvima(Hospital District of Helsinki and Uusimaa), Ying Wu, David F. Choy, Pirkko J. Pussinen, Aino Salminen(Varsinais-Suomen Sairaanhoitopiiri), Tuula Salo(Northern Ostrobothnia Hospital District), David Rice(Northern Ostrobothnia Hospital District), Pekka Nieminen(AbbVie (United States)), Ulla Palotie(AbbVie (United States)), Maria Siponen(AstraZeneca (United Kingdom)), Liisa Suominen(AstraZeneca (United Kingdom)), Päivi Mäntylä(Biogen (United States)), Ulvi Kahraman Gürsoy(Biogen (United States)), Vuokko Anttonen(Biogen (United States)), Kirsi Sipilä(Biogen (United States)), J. Wade Davis, Danjuma Quarless, Slavé Petrovski, Eleonor Wigmore(Bristol-Myers Squibb (United States)), Chia-Yen Chen(Bristol-Myers Squibb (United States)), Paola G. Bronson(Bristol-Myers Squibb (United States)), Ellen Tsai, Yunfeng Huang, Joseph Maranville, Elmutaz Shaikho(Merck & Co., Inc., Rahway, NJ, USA (United States)), Elhaj Mohammed(Pfizer (United States)), Samir Wadhawan(Pfizer (United States)), Erika Kvikstad(GlaxoSmithKline (United Kingdom)), Minal Çalışkan(Sanofi (France)), Diana Chang(Sanofi (France)), Tushar Bhangale(Sanofi (France)), Sarah A. Pendergrass(Sanofi (France)), Emily Holzinger(Sanofi (France)), Xing Chen(Sanofi (France)), Åsa K. Hedman(Sanofi (France)), Karen S. King(Sanofi (France)), Clarence Wang(Maze (United States)), Ethan Xu(University of Helsinki), Franck Augé(University of Helsinki), Clément Chatelain(University of Helsinki), Deepak K. Rajpal(University of Helsinki), Dongyu Liu(University of Helsinki), Katherine M. Call(University of Helsinki), Tai-he Xia(Broad Institute), Matt Brauer(University of Helsinki), Mitja Kurki(Stanford University), Juha Karjalainen(University of Helsinki), Aki S. Havulinna(University of Helsinki), Anu Jalanko(University of Helsinki), Priit Palta(University of Helsinki), Pietro Della Briotta Parolo(University of Helsinki), Wei Zhou(University of Helsinki), Susanna Lemmelä(University of Helsinki), Manuel A. Rivas(University of Helsinki), Jarmo Harju(University of Helsinki), Arto Lehistö(University of Helsinki), Andrea Ganna(University of Helsinki), Vincent Llorens(Tampere University), Hannele Laivuori(Tampere University), Sina Rüeger(University of Helsinki), Mari Niemi(University of Helsinki), Taru Tukiainen(University of Helsinki), Mary Pat Reeve(University of Helsinki), Henrike Heyne(Finnish Institute for Health and Welfare), Kimmo Palin(Finnish Red Cross), Javier Gracia‐Tabuenca(Finnish Red Cross), Harri Siirtola(Hospital District of Helsinki and Uusimaa), Tuomo Kiiskinen(Borealis (Finland)), Jiwoo Lee(Borealis (Finland)), Kristin Tsuo(Borealis (Finland)), Amanda Elliott(Borealis (Finland)), Kati Kristiansson(Tampere University), Kati Hyvärinen(University of Eastern Finland), Jarmo Ritari(Central Finland Health Care District), Miika Koskinen(University of Turku), Katri Pylkäs(University of Turku), Marita Kalaoja(University of Turku), Minna K. Karjalainen(University of Turku), Tuomo Mantere(University of Turku), Eeva Kangasniemi(University of Helsinki), Sami Heikkinen(University of Helsinki), Eija K. Laakkonen(University of Helsinki), Csilla Sipeky(University of Helsinki), Samuel Heron(University of Helsinki), Antti Karlsson(Broad Institute), Dhanaprakash Jambulingam(University of Helsinki), Venkat Subramaniam Rathinakannan(University of Helsinki), Risto Kajanne(University of Helsinki), Mervi Aavikko(University of Helsinki), Manuel González Jiménez(University of Helsinki), Pietro della Briotta Parola(University of Helsinki), Arto Lehistö(University of Helsinki), Masahiro Kanai(Hospital District of Helsinki and Uusimaa), Mari Kaunisto(Finnish Institute for Health and Welfare), Elina Kilpeläinen(Finnish Institute for Health and Welfare), Timo P. Sipilä(Finnish Institute for Health and Welfare), Georg Brein(Finnish Institute for Health and Welfare), Awaisa Ghazal(Finnish Institute for Health and Welfare), Anastasia Shcherban(Finnish Institute for Health and Welfare), Kati Donner(Finnish Institute for Health and Welfare), Anu Loukola(Finnish Institute for Health and Welfare), Päivi Laiho(Finnish Institute for Health and Welfare), Tuuli Sistonen(Finnish Institute for Health and Welfare), Essi Kaiharju(Finnish Institute for Health and Welfare), Markku Laukkanen(University of Helsinki), Elina Järvensivu(Tampere University), Sini Lähteenmäki(University of Kentucky), Lotta Männikkö(The University of Texas Southwestern Medical Center), Regis Wong(The University of Texas at Austin), Hannele Mattsson(Johns Hopkins University), Tero Hiekkalinna(University of Michigan), Teemu Paajanen(Mayo Clinic in Florida), Kalle Pärn(University of North Texas), Javier Gracia‐Tabuenca(Indiana University School of Medicine), ADGC(University of Pennsylvania), Erin L. Abner(University of Wisconsin–Madison), Perrie M. Adams(University of Wisconsin–Madison), Alyssa Aguirre(The University of Texas at Austin), Marilyn S. Albert(Boston University), Roger L. Albin(University of North Texas), Mariet Allen(Rush University Medical Center), Lisa Alvarez(Columbia University), Liana G. Apostolova(Banner Sun Health Research Institute), Steven E. Arnold(University of Pittsburgh), Sanjay Asthana(University of Miami), Craig Atwood(University of Washington), Gayle Ayres(Vanderbilt University), Clinton T. Baldwin(Case Western Reserve University), Robert C. Barber(Hope Center for Neurological Disorders), Lisa L. Barnes(Rush University Medical Center), Sandra Barral(University of Parma), Thomas G. Beach(Northwestern University), James T. Becker(VA Puget Sound Health Care System), Gary W. Beecham(Harvard University), Duane Beekly(Mayo Clinic in Arizona), Jennifer E. Below(Vanderbilt University), Penelope Benchek(University of California, San Francisco), Bruno A. Benítez(University of California San Diego), David Bennett(Duke University), John Bertelson(University of Kansas Medical Center), Margaret E. Flanagan(Case Western Reserve University), Thomas D. Bird(Allen Institute for Brain Science), Deborah Blacker(Washington University in St. Louis), Bradley F. Boeve(University of South Florida), James D. Bowen(Fred Hutch Cancer Center), Adam Boxer(University of Wisconsin–Madison), James B. Brewer(Bruce W. Carter VA Medical Center), James R. Burke(Mayo Clinic in Florida), Jeffrey M. Burns(University of North Carolina at Chapel Hill), William S. Bush(University of California, Los Angeles), Joseph D. Buxbaum(University of Pennsylvania), Nigel J. Cairns(University of Wisconsin–Madison), Chuanhai Cao(University of Southern California), Christopher S. Carlson(Boston University), Cynthia M. Carlsson(Wake Forest University), Regina M. Carney(University of Washington), Minerva M. Carrasquillo(University of California, Irvine), Scott Chasse(University of Miami), Marie‐Françoise Chesselet(Washington University in St. Louis), Alessandra Chesi(University of Miami), Nathaniel A. Chin(The University of Texas Southwestern Medical Center), Helena C. Chui(Baylor College of Medicine), Jaeyoon Chung(Boston University), Suzanne Craft(Columbia University Irving Medical Center), Paul K. Crane(University of California, Davis), David H. Cribbs(Texas Tech University), Elizabeth Crocco(University of California, Irvine), Carlos Cruchaga(Mayo Clinic in Florida), Michael L. Cuccaro(University of Miami), C. Munro Cullum(Baylor College of Medicine), Eveleen Darby(Mount Sinai Medical Center), Bárbara Davis(Mayo Clinic in Florida), Philip L. De Jager(Rush University Medical Center), Charles DeCarli(University of North Texas), John C. DeToledo(University of Alabama at Birmingham), Malcolm Dick(Indiana University – Purdue University Indianapolis), Dennis W. Dickson(Boston University), Beth A. Dombroski(Hope Center for Neurological Disorders), Rachelle S. Doody(New York University), Ranjan Duara(Massachusetts General Hospital), Nilüfer Ertekin‐Taner(Icahn School of Medicine at Mount Sinai), Denis A. Evans(University of California San Diego), Thomas Fairchild(University of North Texas), Kenneth B. Fallon(Emory Healthcare), Martin R. Farlow(Washington University in St. Louis), John J. Farrell(Indiana University – Purdue University Indianapolis), Victoria Fernandez-Hernandez(University of Miami), Steven H. Ferris(University of Washington), Matthew P. Frosch(University of North Texas), Brian Fulton‐Howard(Children's Hospital of Philadelphia), Douglas R. Galasko(Brigham and Women's Hospital), Adriana C. Gamboa(Harvard University), Marla Gearing(Case Western Reserve University), Daniel H. Geschwind(Children's Hospital of Philadelphia), Bernardino Ghetti(University of North Texas), John R. Gilbert(University of Pittsburgh), Thomas J. Grabowski(Washington University in St. Louis), Neill R. Graff‐Radford(University of Alabama at Birmingham), Struan F.A. Grant(University of Pennsylvania), Robert C. Green(University of California, Irvine), John H. Growdon(Stanford University), Jonathan L. Haines(Texas Tech University), Håkon Håkonarson(Vanderbilt University Medical Center), James Hall(Columbia University), Ronald L. Hamilton(The University of Texas Southwestern Medical Center), Oscar Harari(Translational Genomics Research Institute), Lindy E. Harrell(Duke University), Jacob Haut(Harvard University), Elizabeth Head(The University of Texas Southwestern Medical Center), Victor W. Henderson(Washington University in St. Louis), Michelle L. Hernandez(University of Washington), Timothy J. Hohman(University of Washington), Lawrence S. Honig(University of California, Davis), Ryan Huebinger(Texas Tech University), Matthew J. Huentelman(University of North Texas), Christine M. Hulette(University of Pittsburgh), Bradley T. Hyman(University of California, San Francisco), Linda S. Hynan(Albert Einstein College of Medicine), Laura Ibáñez(Oregon Health & Science University), Gail P. Jarvik(University of Washington), Suman Jayadev(Baylor College of Medicine), Lee‐Way Jin(University of California, Irvine), Kim G. Johnson(University of North Texas), Leigh A. Johnson(Boston University), M. Ilyas Kamboh(University of California, San Francisco), Anna M. Karydas(University of Pennsylvania), Mindy J. Katz(University of California, Irvine), Jeffrey A. Kaye(Emory University), C. Dirk Keene(Kaiser Permanente Washington Health Research Institute), Aisha Khaleeq(University of Pennsylvania), Ronald Kim(University of Pennsylvania), Janice Knebl(Case Western Reserve University), Neil W. Kowall(University of Pennsylvania), Joel H. Kramer(Cleveland Clinic), Pavel P. Kuksa(Emory University), Frank M. LaFerla(University of Pennsylvania), James J. Lah(University of Michigan), Eric B. Larson(Albert Einstein College of Medicine), Chien‐Yueh Lee(National Center for PTSD), Edward B. Lee(Johns Hopkins University), Alan J. Lerner(University of Pennsylvania), Yuk Yee Leung(University of North Texas), James B. Leverenz(University of Alabama at Birmingham), Allan I. Levey(New York University), Mingyao Li(University of Miami), Andrew P. Lieberman(University of California San Diego), Richard B. Lipton(Baylor College of Medicine), Mark Logue(New York University), Constantine G. Lyketsos(University of Washington), John Malamon(University of Washington), Douglas Mains(Fred Hutch Cancer Center), Daniel Marson(Pfizer (United States)), Frank Martiniuk(Boston University), Deborah C. Mash(Northwestern University), Eliezer Masliah(University of Eastern Finland), Paul J. Massman(University of California, San Francisco), Arjun V. Masurkar(University of Southern California), Wayne C. McCormick(University of California, Davis), Susan M. McCurry(Stanford University), Andrew McDavid(University of California, Irvine), Stefan McDonough(Washington University in St. Louis), Ann C. McKee(University of Miami), Marsel Mesulam(The University of Texas Southwestern Medical Center), Jesse Mez(University of North Texas), Bruce L. Miller(University of California, Davis), Carol A. Miller, Joshua W. Miller(The University of Texas at San Antonio Health Science Center), Thomas J. Montine(Mayo Clinic in Arizona), Edwin S. Monuki(University of Michigan), John C. Morris(Baylor College of Medicine), Amanda Myers(The University of Texas at Austin), Trung Nguyen(Texas Tech University), Sid E. O’Bryant(University of Washington), John Olichney(Mayo Clinic in Arizona), Marcia G. Ory(University of Pennsylvania), Raymond F. Palmer(University of California, Irvine), Joseph E. Parisi(New York University), Henry L. Paulson(University of California, Irvine), Valory Pavlik(University of Colorado Denver), David Paydarfar(University of Pennsylvania), Victòria Aurora Ferrer Pérez(University of North Texas), Elaine R. Peskind(Oregon Health & Science University), Ronald C. Petersen(University of South Florida), Jennifer E. Phillips‐Cremins(University of Washington), Aimee Pierce(Translational Genomics Research Institute), Marsha J. Polk(New York University), Wayne W. Poon(The University of Texas Southwestern Medical Center), Huntington Potter(University of Southern California), Liming Qu(University of Alabama at Birmingham), Mary Quiceno(Baylor College of Medicine), Joseph F. Quinn(University of Toronto), Ashok Raj(University of California, San Francisco), Murray A. Raskind(The University of Texas Southwestern Medical Center), Eric M. Reiman(The University of Texas at San Antonio Health Science Center), Barry Reisberg(University of Wisconsin–Madison), Joan Reisch(Icahn School of Medicine at Mount Sinai), John M. Ringman(Indiana University – Purdue University Indianapolis), Erik D. Roberson(Rush University Medical Center), Monica Rodriguear(University of Southern California), Ekaterina Rogaeva(University of California, San Francisco), Howard J. Rosen(University of Miami), Roger N. Rosenberg(Columbia University), Donald R. Royall(University of South Florida), Mark A. Sager(The University of Texas Southwestern Medical Center), Mary Sano(Case Western Reserve University), Andrew J. Saykin(University of Washington), Julie A. Schneider(Indiana University – Purdue University Indianapolis), Lon S. Schneider(University of Toronto), William W. Seeley(University of Eastern Finland), Susan H. Slifer(University of Miami), Scott A. Small(Yale University), Amanda Smith(University of California, Irvine), Janet P. Smith(University of Kansas Medical Center), Yeunjoo E. Song(Harvard University), Joshua A. Sonnen(University of North Carolina at Chapel Hill), Salvatore Spina(University of Pennsylvania), Peter St George‐Hyslop(Johns Hopkins University), Robert A. Stern(University of Washington), Alan Stevens(University of Pennsylvania), Stephen M. Strittmatter(University of Pennsylvania), David L. Sultzer(University of Kentucky), Russell H. Swerdlow(Northwestern University), Rudolph E. Tanzi(University of Southern California), Jeffrey L. Tilson(Columbia University), John Q. Trojanowski(Northwestern University), Juan C. Troncoso(Duke University), Debby W. Tsuang(University of Miami), Otto Valladares(University of Washington), Vivianna M. Van Deerlin(University of North Carolina at Chapel Hill), Linda J. Van Eldik(Wake Forest University), Robert Vassar(Columbia University), Harry V. Vinters(Texas Tech University), Jean‐Paul Vonsattel(Emory University), Sandra Weıntraub(New York University), Kathleen A. Welsh‐Bohmer(Oregon Health & Science University), Patrice L. Whitehead(The University of Texas at Austin), Ellen M. Wijsman(University of Miami), Kirk C. Wilhelmsen(Texas Tech University), Benjamin Williams(WinnMed), Jennifer Williamson(University of Washington), Henrik Wilms(Rush University Medical Center), Thomas S. Wingo(Children's Hospital of Philadelphia), Thomas Wısnıewskı(Fondazione Santa Lucia), Randall L. Woltjer(Case Western Reserve University), Martin Woon(Inserm), Clinton B. Wright, Chuang‐Kuo Wu(Washington University in St. Louis), Steven G. Younkin(Curtin University), Chang‐En Yu(Boston University), Lei Yu(The University of Texas at San Antonio Health Science Center), Yuanchao Zhang(University of Pittsburgh), Yi Zhao(German Center for Neurodegenerative Diseases), Xiongwei Zhu(Brigham and Women's Hospital), CHARGE(Université de Bordeaux), Hieab H.H. Adams(Erasmus MC), Rufus Akinyemi(University of Edinburgh), Muhammad Ali(Boston University), Nicola J. Armstrong(UNSW Sydney), Hugo J. Aparicio(University of California, Davis), Maryam Bahadori(Université de Bordeaux), James T. Becker(Boston University), Monique M.B. Breteler(Erasmus MC), Daniel I. Chasman(University of Pittsburgh), Ganesh Chauhan(University of Washington), Hata Comic(University of Washington), Simon R. Cox(University of Pittsburgh), L. Adrienne Cupples(University Medical Center Utrecht), Gail Davies(SUNY Upstate Medical University), Charles DeCarli(University of California San Diego), Marie-Gabrielle Duperron(The University of Texas at San Antonio Health Science Center), Josée Dupuis(Universitätsmedizin Greifswald), Tavia E. Evans(The University of Texas at San Antonio Health Science Center), Frank Fan(The University of Texas Health Science Center at Houston), Annette L. Fitzpatrick(Medical University of Graz), Alison E. Fohner(University of Maryland, College Park), Mary Ganguli(The University of Texas at San Antonio Health Science Center), Mirjam I. Geerlings(The University of Texas at San Antonio Health Science Center), Stephen J. Glatt(Erasmus MC), Héctor M. González(Erasmus MC), Monica Goss(Monash University), Hans J. Grabe(University of Helsinki), Mohamad Habes(Université de Bordeaux), Susan R. Heckbert(University of Colorado Anschutz Medical Campus), Edith Hofer(Boston University), Elliot Hong(German Center for Neurodegenerative Diseases), Timothy M. Hughes(Boston University), Tiffany F. Kautz(Medical University of Graz), Maria J. Knol(Harvard University), William S. Kremen(University of California, Davis), Paul Lacaze, Jari Lahti(Université de Bordeaux), Quentin Le Grand(The University of Texas at San Antonio Health Science Center), Elizabeth Litkowski(Jackson Memorial Hospital), Shuo Li(Université de Bordeaux), Dan Liu(Johns Hopkins University), Xuan Liu(University of Maryland, College Park), Marisa Loitfelder(University of Toronto), Alisa K. Manning(Centre Hospitalier Universitaire Sainte-Justine), Pauline Maillard(University of Toronto), Riccardo E. Marioni(University of Helsinki), Bernard Mazoyer(Monash University), Debora Melo van Lent(Monash University), Hao Mei(The Lundquist Institute), Aniket Mishra(Boston Medical Center), Paul Nyquist(Erasmus MC), Jeffrey R. O’Connell(Medical University of Graz), Yash Patel(Medical University of Graz), Tomáš Paus(Medical University of Graz), Zdenka Pausová(Medical University of Graz), Katri Raikkonen-Talvitie(Baylor College of Medicine), Moeen Riaz(University of Michigan), Stephen S. Rich(Université de Bordeaux), Jerome I. Rotter(Université de Bordeaux), José R. Romero(University of Toronto), Gena Roshchupkin(Jackson Memorial Hospital), Yasaman Saba(Jackson Memorial Hospital), Muralidharan Sargurupremraj(Universitätsmedizin Greifswald), Helena Schmidt(University of North Carolina at Chapel Hill), Reinhold Schmidt(Jackson Memorial Hospital), Joshua Shulman(The University of Texas at Austin), Jennifer A. Smith(Erasmus MC), Hema Sekhar(German Center for Neurodegenerative Diseases), Reddy Rajula(Medical University of Graz), Jean Shin(Karolinska Institutet), Jeannette Simino(German Center for Neurodegenerative Diseases), Eeva Sliz(Johns Hopkins University), Alexander Teumer(The University of Texas Health Science Center at Houston), Alvin G. Thomas(Boston University), Adrienne Tin(University of Washington), Elliot M. Tucker–Drob(Erasmus MC), Dina Vojinović(Allen Institute for Brain Science), Yanbing Wang(UNSW Sydney), Galit Weinstein(UNSW Sydney), Dylan M. Williams(University Hospital Bonn), Katharina Wittfeld(Erasmus MC), Lisa R. Yanek(University of Lisbon), Yunju Yang(National Institutes of Health), Lindsay A. Farrer(Boston University), Bruce M. Psaty(University of Eastern Finland), Mohsen Ghanbari(Inserm), Towfique Raj(Allen Institute for Brain Science), Perminder S. Sachdev(University of Copenhagen), Karen A. Mather(Universitat Autònoma de Barcelona), Frank Jessen(Commissariat à l'Énergie Atomique et aux Énergies Alternatives), M. Arfan Ikram(Erasmus MC), Alexandre de Mendonça(University of Lisbon), Jakub Hort(National Institutes of Health), Magda Tsolaki(Uppsala University), Margaret A. Pericak‐Vance(University of Eastern Finland), Philippe Amouyel(University of Antwerp), Julie Williams(Cardiff University), Ruth Frikke‐Schmidt(University of Copenhagen), Jordi Clarimón(Universitat Autònoma de Barcelona), Jean‐François Deleuze(Commissariat à l'Énergie Atomique et aux Énergies Alternatives), Giacomina Rossi(Instituto de Salud Carlos III), Sudha Seshadri(Boston University), Ole A. Andreassen(Inserm), Martin Ingelsson(Uppsala University), Mikko Hiltunen(Universidade Federal do Rio Grande do Norte), Kristel Sleegers(University of Antwerp), Gerard D. Schellenberg(University of Pennsylvania), Cornelia M. van Duijn(Erasmus MC), Rebecca Sims(Cardiff University), Wiesje M. van der Flier(Amsterdam Neuroscience), Agustı́n Ruiz(Instituto de Salud Carlos III), Alfredo Ramı́rez(The University of Texas at San Antonio Health Science Center), Jean‐Charles Lambert(Inserm)
Cited by 2,430Open Access
Abstract
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele.