Predictive high-throughput screening of PEGylated lipids in oligonucleotide-loaded lipid nanoparticles for neuronal gene silencing

Apoorva Sarode; Yuchen Fan; Amy E. Byrnes; Michal Hammel; Greg L. Hura; Yige Fu; Ponien Kou; Chloe Hu; Flora I. Hinz; Jasmine Roberts; Stefan G. Koenig; Karthik Nagapudi; Casper C. Hoogenraad; Tao Chen; Dennis Leung; Chun‐Wan Yen

doi:10.1039/d1na00712b

Predictive high-throughput screening of PEGylated lipids in oligonucleotide-loaded lipid nanoparticles for neuronal gene silencing

Apoorva Sarode, Yuchen Fan, Amy E. Byrnes, Michal Hammel, Greg L. Hura(University of California, Santa Cruz), Yige Fu, Ponien Kou, Chloe Hu, Flora I. Hinz, Jasmine Roberts, Stefan G. Koenig, Karthik Nagapudi, Casper C. Hoogenraad, Tao Chen, Dennis Leung, Chun‐Wan Yen

Nanoscale Advances

January 1, 2022

10.1039/d1na00712b

Cited by 70Open Access

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Abstract

efficacy. The reported HTS workflow can be used to screen additional multivariate parameters of LNPs with significant time and material savings, therefore guiding the selection and scale-up of optimal formulations for nucleic acid delivery to a variety of cellular targets.

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