Effects of Antiplatelet Therapy After Stroke Caused by Intracerebral Hemorrhage

Rustam Al‐Shahi Salman(University of Edinburgh), Martin Dennis(Campbell Collaboration), Peter Sandercock(University of Edinburgh), Cathie Sudlow(Campbell Collaboration), Joanna M. Wardlaw(UK Dementia Research Institute), William Whiteley(Campbell Collaboration), Gordon Murray(University of Edinburgh), Jacqueline Stephen(University of Edinburgh), Aryelly Rodríguez(University of Edinburgh), Steff Lewis(University of Edinburgh), David J. Werring(National Hospital for Neurology and Neurosurgery), Phil White(National Health Service), Colin Baigent(Campbell Collaboration), Daniel Lasserson(Campbell Collaboration), Frank Sullivan(Campbell Collaboration), Johanna Carrie(Campbell Collaboration), David E. Newby(Campbell Collaboration), Nikola Sprigg(Campbell Collaboration), Javier Rojas(Campbell Collaboration), Bernadette Gallagher(Campbell Collaboration), Elizabeth Brownsell(Campbell Collaboration), Paul Dearie(Campbell Collaboration), Alice Graves(Campbell Collaboration), Louisa Wilson(Campbell Collaboration), Gelnna Hamer(Campbell Collaboration), Elizabeth A. Craig(Campbell Collaboration), Priscilla Sauramba(Campbell Collaboration), Nicola Lyttle(Campbell Collaboration), Shannon Amoils(Campbell Collaboration), John Bamford(Campbell Collaboration), Jane Armitage(Campbell Collaboration), Gabriël J.E. Rinkel(Campbell Collaboration), Gordon Lowe(Campbell Collaboration), Jonathan Emberson(Campbell Collaboration), Karen Innes(Campbell Collaboration), Lynn Dinsmore(Campbell Collaboration), Jonathan Drever(Campbell Collaboration), Carol Williams(Campbell Collaboration), David Perry(Campbell Collaboration), Connor McGill(Campbell Collaboration), David L. Buchanan(Campbell Collaboration), Allan Walker(Campbell Collaboration), Aidan Hutchison(Campbell Collaboration), Christopher R. Matthews(Campbell Collaboration), Ruth Fraser(Campbell Collaboration), Aileen McGrath(Campbell Collaboration), Ann Deary(Campbell Collaboration), Rosemary Anderson(Campbell Collaboration), Pauli Walker(Campbell Collaboration), Kasia Adamczuk(Campbell Collaboration), Christian Holm Hansen(Campbell Collaboration), Richard Parker(Campbell Collaboration), Robert J Lee(Campbell Collaboration), Malcolm Macleod(Campbell Collaboration), Thomas Moullaali(Campbell Collaboration), Jeb Palmer(Campbell Collaboration), Eleni Sakka(Campbell Collaboration), Jennifer Adil-Smith(Campbell Collaboration), David Minks(Campbell Collaboration), Dipayan Mitra(Campbell Collaboration), Priya Bhatnagar(Campbell Collaboration), Johan du Plessis(Campbell Collaboration), Yogish Joshi(Campbell Collaboration), Kelly Stewart(Campbell Collaboration), Kate Covil(Campbell Collaboration), Mark Rodrigues(Campbell Collaboration), Christine Lerpiniere(Campbell Collaboration), Richard O’Brien(Campbell Collaboration), Seona Burgess(Campbell Collaboration), Gillian Mead(Campbell Collaboration), Ruth Paulton(Campbell Collaboration), Fergus Doubal(Campbell Collaboration), Katrina McCormick(Campbell Collaboration), Neil Hunter(Campbell Collaboration), Pat Taylor(Campbell Collaboration), Ruwan Parakramawansha(Campbell Collaboration), Jack Perry(Campbell Collaboration), Gordon W. Blair(Campbell Collaboration), Allan MacRaild(Campbell Collaboration), Adrian Parry‐Jones(Campbell Collaboration), Mary Johnes(Campbell Collaboration), Stephanie J. Lee(Campbell Collaboration), Kelly Marie Shaw(Campbell Collaboration), Ilse Burger(Campbell Collaboration), Martin Punter(Campbell Collaboration), Andrea Ingham(Campbell Collaboration), Jane Perez(Campbell Collaboration), Zin Naing(Campbell Collaboration), Jordi Morell(Campbell Collaboration), Tracy Marsden(Campbell Collaboration), Andrea C. Hall(Campbell Collaboration), Sally J. Marshall(Campbell Collaboration), Louise Harrison(Campbell Collaboration), R. Jarapa(Campbell Collaboration), Edith Wood(Campbell Collaboration), V. O'Loughlin(Campbell Collaboration), David Cohen(Campbell Collaboration), Silvie Davies(Campbell Collaboration), Kelechi Njoku(Campbell Collaboration), Mushiya Mpelembue(Campbell Collaboration), Laura Burgess(Campbell Collaboration), Radim Líčeník(Campbell Collaboration), Mmua Ngwako(Campbell Collaboration), Nabeela Nisar(Campbell Collaboration), Rangah Niranchanan(Campbell Collaboration), Tatjana Roganova(Campbell Collaboration), Rajaram Bathula(Campbell Collaboration), Joseph E. Devine(Campbell Collaboration), Anette David(Campbell Collaboration), Anne Oshodi(Campbell Collaboration), Fenglin Guo(Campbell Collaboration), Emmanuelle Owoyele(Campbell Collaboration), Varthi Sukdeo(Campbell Collaboration), ROBERT I. W. BALLANTINE(Campbell Collaboration), Mudhar Abbdul-saheb(Campbell Collaboration), Angela Chamberlain(Campbell Collaboration), Aberami Chandrakumar(Campbell Collaboration), Philip Poku(Campbell Collaboration), Kirsty Harkness(Campbell Collaboration), Emma Richards(Campbell Collaboration), Ali Ali(Campbell Collaboration), Catrin Blank(Campbell Collaboration), Faith Kibutu(Campbell Collaboration), O. Yu. Balitska(Campbell Collaboration), Kathryn Birchall(Campbell Collaboration), Pauline Bayliss(Campbell Collaboration), Kathy Stocks(Campbell Collaboration), Arshad Majis(Campbell Collaboration), Clare Doyle(Campbell Collaboration), Jo Howe(Campbell Collaboration), Christine Kamara(Campbell Collaboration), Luke Barron(Campbell Collaboration), Ahmad Maatouk(Campbell Collaboration), Ralf Lindert(Campbell Collaboration), Katy Dakin(Campbell Collaboration), Jessica Redgrave(Campbell Collaboration), John C. France(Campbell Collaboration), Dawn Tomlin(Campbell Collaboration), Helen Bearne(Campbell Collaboration), Isam Salih(Campbell Collaboration), Debs Kelly(Campbell Collaboration), Susan Szabo(Campbell Collaboration), Biju Bhaskaran(Campbell Collaboration), Jean Buxton(Campbell Collaboration), Pauline Fitzell(Campbell Collaboration), Georgina Ayres(Campbell Collaboration), Afaq Saulat(Campbell Collaboration), Kathleen Horan(Campbell Collaboration), Joanne Garfield-Smith(Campbell Collaboration), Harbens Bhakri(Campbell Collaboration), Stacey Atkins(Campbell Collaboration), Joan Redome(Campbell Collaboration), Paul Guyler(Campbell Collaboration), Thayalini Loganathan(Campbell Collaboration), Amber Siddiqui(Campbell Collaboration), Anwer Siddiqui(Campbell Collaboration), Lucy Coward(Campbell Collaboration), Devesh Sinha(Campbell Collaboration), Swapna Kunhunny(Campbell Collaboration), Sharon Tysoe(Campbell Collaboration), Rajalakshmi Orath Prabakaran(Campbell Collaboration), Shyam Kelavkar(Campbell Collaboration), Sindhu Rashmi(Campbell Collaboration), David Ngo(Campbell Collaboration), Kheng Xiong Ng(Campbell Collaboration), Nisha Menon(Campbell Collaboration), Sweni Shah(Campbell Collaboration), Mark Barber(Campbell Collaboration), Derek Esson(Campbell Collaboration), Fiona Brodie(Campbell Collaboration), Talat Anjum(Campbell Collaboration), Manju Krishnan(Campbell Collaboration), Leanne Quinn(Campbell Collaboration), Jayne Spencer(Campbell Collaboration), Terry E. Jones(Campbell Collaboration), Helen Thompson Jones(Campbell Collaboration), Srikanth Chenna(Campbell Collaboration), Sharon Storton(Campbell Collaboration), Lynne Dacey(Campbell Collaboration), Sarah Thomas(Campbell Collaboration), Teresa Beaty(Campbell Collaboration), Mushtaq Ahmad Wani(Campbell Collaboration), Shelley Treadwell(Campbell Collaboration), Caroline Davies(Campbell Collaboration), Susan Tucker(Campbell Collaboration), Lynda Connor(Campbell Collaboration), Glyn Gainard(Campbell Collaboration), Peter Slade(Campbell Collaboration), Girish Muddegowda(Campbell Collaboration), Nenette Abano(Campbell Collaboration), Alda Remegoso(Campbell Collaboration), Racquel Carpio(Campbell Collaboration), Chelsea Causley(Campbell Collaboration), Stephanie Stevens(Campbell Collaboration), Adrian Butler(Campbell Collaboration), Resti Varquez(Campbell Collaboration), Andrew Moores(Campbell Collaboration), Francis Alipio(Campbell Collaboration), Hayley Denic(Campbell Collaboration), Ranjan Sanyal(Campbell Collaboration), Adrian Barry(Campbell Collaboration), Holly Maguire(Campbell Collaboration), Jeanette Grocott(Campbell Collaboration), K. Finney(Campbell Collaboration), Sue Lyjko(Campbell Collaboration), Christine Roffe(Campbell Collaboration), Joanne Hiden(Campbell Collaboration), Phillip Ferdinand(Campbell Collaboration), Vera Cvoro(Campbell Collaboration), Khalil Ullah(Campbell Collaboration), Nicola Chapman(Campbell Collaboration), Mandy Couser(Campbell Collaboration), Susan Pound(Campbell Collaboration), Sean Mcauley(Campbell Collaboration), Senthil Raghunathan(Campbell Collaboration), Faye Shelton(Campbell Collaboration), Amanda Hedstrom(Campbell Collaboration), Margi Godfrey(Campbell Collaboration), Diane Havard(Campbell Collaboration), Amanda Buck(Campbell Collaboration), Kailash Krishnan(Campbell Collaboration), Nicola Gilzeane(Campbell Collaboration), Jack Roffe(Campbell Collaboration), Judith Clarke(Campbell Collaboration), Saima Sheikh(Campbell Collaboration), Katherine Whittamore(Campbell Collaboration), Rekha Keshvara(Campbell Collaboration), Carla Jordan(Campbell Collaboration), Gwendoline Wilkes(Campbell Collaboration), Benjamin Jackson(Campbell Collaboration), Jason P. Appleton(Campbell Collaboration), Zhe Kang Law(Campbell Collaboration), Oliver Matias(Campbell Collaboration), Evangelos Vasileiadis(Campbell Collaboration), Cathy Mason(Campbell Collaboration), Anthea Parry(Campbell Collaboration), G Landers(Campbell Collaboration), Melinda Holden(Campbell Collaboration), Basaam Aweid(Campbell Collaboration), Khalid Rashed(Campbell Collaboration), L. Balian(Campbell Collaboration), Carinna Vickers(Campbell Collaboration), Elizabeth G. Keeling(Campbell Collaboration), Sarah Board(Campbell Collaboration), Joanna Allison(Campbell Collaboration), C Buckley(Campbell Collaboration), Barbara Williams-Yesson(Campbell Collaboration), Joanne Board(Campbell Collaboration), T Pitt-Kerby(Campbell Collaboration), Alfonso Tanate(Campbell Collaboration), Diane P. Wood(Campbell Collaboration), Dinesh Chadha(Campbell Collaboration), Manohar Kini(Campbell Collaboration), Deborah Walstow(Campbell Collaboration), Rosanna Fong(Campbell Collaboration), Robert Luder(Campbell Collaboration), Tolu Adesina(Campbell Collaboration), Jill Gallagher(Campbell Collaboration), Hayley Bridger(Campbell Collaboration), Elodie Murali(Campbell Collaboration), Larissa Cuenoud(Campbell Collaboration), Maneesh Bhargava(Campbell Collaboration), Chloe van Someren(Campbell Collaboration), Katja Adie(Campbell Collaboration), Gillian Courtauld(Campbell Collaboration), Christine Schofield(Campbell Collaboration), Abhijit Mate(Campbell Collaboration), Ali James(Campbell Collaboration), Frances Harrington(Campbell Collaboration), Linda F. Lucas(Campbell Collaboration), Kirsty Bond(Campbell Collaboration), Bev Maund(Campbell Collaboration), Sam Ellis(Campbell Collaboration), Emilie Williams(Campbell Collaboration), Sue Webber(Campbell Collaboration), Terri Chant(Campbell Collaboration), Elizabeth Swanson(Campbell Collaboration), E. J. King(Campbell Collaboration), Abbie Coutts(Campbell Collaboration), Nicola Yeo(Campbell Collaboration), Paul N. Mudd(Campbell Collaboration), Martin James(Campbell Collaboration), Hayley Kingwell(Campbell Collaboration), Caroline Roughan(Campbell Collaboration), Anthony Hemsley(Campbell Collaboration), Jane Sword(Campbell Collaboration), Samantha Keenan(Campbell Collaboration), A Bowring(Campbell Collaboration), Julie Cageao(Campbell Collaboration), W. David Strain(Campbell Collaboration), Keniesha Miller(Campbell Collaboration), Anita Goff(Campbell Collaboration), Karin Gupwell(Campbell Collaboration), Kevin E. Thorpe(Campbell Collaboration), Hedley Emsley(Campbell Collaboration), Alison McLoughlin(Campbell Collaboration), Sulaiman Sultan(Campbell Collaboration), Shuja Punekar(Campbell Collaboration), Bindu Gregory(Campbell Collaboration), Sonia Raj(Campbell Collaboration), Donna Doyle(Campbell Collaboration), Keith W. Muir(Campbell Collaboration), W. G. J. Smith(Campbell Collaboration), Fiona Moreton(Campbell Collaboration), Bharath Kumar Cheripelli(Campbell Collaboration), Salwa El Tawil(Campbell Collaboration), Dheeraj Kalladka(Campbell Collaboration), Angela Welch(Campbell Collaboration), Xuya Huang(Campbell Collaboration), Nicola C. Day(Campbell Collaboration), Sankaranarayanan Ramachandran(Campbell Collaboration), Caroline Crosbie(Campbell Collaboration), Jennifer Elliot(Campbell Collaboration), Peter Sommerville(Campbell Collaboration), Meegan Gibbons(Campbell Collaboration), Rowshanara Ahmed(Campbell Collaboration), Sagal Kullane(Campbell Collaboration), Katherine Marks(Campbell Collaboration), Ajay Bhalla(Campbell Collaboration), Jonathan Birns(Campbell Collaboration), Tony Rudd(Campbell Collaboration), Nic Weir(Campbell Collaboration), Christopher Allen(Campbell Collaboration), Vanessa Pressly(Campbell Collaboration), Pam Crawford(Campbell Collaboration), Emma Battersby-Wood(Campbell Collaboration), Alex Blades(Campbell Collaboration), Shuna Egerton(Campbell Collaboration), Ashleigh Walters(Campbell Collaboration), Richard Marigold(Campbell Collaboration), Sue Evans(Campbell Collaboration), Fiona E. Smith(Campbell Collaboration), Gabriella Howard(Campbell Collaboration), Imogen Gartrell(Campbell Collaboration), Simon Smith(Campbell Collaboration), Chloe Cox(Campbell Collaboration), Robyn Creeden(Campbell Collaboration), Cherish Boxall(Campbell Collaboration), Jonathan Hewitt(Campbell Collaboration), Claire Nott(Campbell Collaboration), Procter Sarah(Campbell Collaboration), Jessica Whiteman(Campbell Collaboration), Steve Buckle(Campbell Collaboration), Rina Mardania(Campbell Collaboration), Jane Gray(Campbell Collaboration), Rebecca Wallace(Campbell Collaboration), Claire Triscott(Campbell Collaboration), Anand R. Nair(Campbell Collaboration), Jill Greig(Campbell Collaboration), Pratap Rana(Campbell Collaboration), Matthew K. Robinson(Campbell Collaboration), Mohammad Irfan Alam(Campbell Collaboration), Ridha Ramiz(Campbell Collaboration), David J. Werring(National Hospital for Neurology and Neurosurgery), Duncan Wilson(Campbell Collaboration), C Watchurst(Campbell Collaboration), Maria Brezitski(Campbell Collaboration), Ifan Jones(Campbell Collaboration), Luci Crook(Campbell Collaboration), Azra Banaras(Campbell Collaboration), Krishna Patel(Campbell Collaboration), Renuka Erande(Campbell Collaboration), Caroline Hogan(Campbell Collaboration), Talal Al‐Mayhani(Campbell Collaboration), Isabel C. Hostettler(Campbell Collaboration), Amy Ashton(Campbell Collaboration), Shez Feerick(Campbell Collaboration), Nina Francia(Campbell Collaboration), Nnebuife Oji(Campbell Collaboration), Emma Elliott(Campbell Collaboration), Martin Dennis(Campbell Collaboration), William Whiteley(Campbell Collaboration), Cathie Sudlow(Campbell Collaboration), Dipankar Dutta(Campbell Collaboration), Pauline Brown(Campbell Collaboration), Deborah Ward(Campbell Collaboration), Fiona Davis(Campbell Collaboration), Jennifer Turfrey(Campbell Collaboration), Chloe Hughes(Campbell Collaboration), Kayleigh Collins(Campbell Collaboration), Rehana Bakawala(Campbell Collaboration), Susan O’Çonnell(Campbell Collaboration), Jon Glass(Campbell Collaboration), David Broughton(Campbell Collaboration), Lynn Dixon(Campbell Collaboration), Kath Chapman(Campbell Collaboration), Andrew Young(Campbell Collaboration), Adrian Bergin(Campbell Collaboration), Dinesh Tryambake(Campbell Collaboration), Andrew Sigsworth(Campbell Collaboration), Aravind Manoj(Campbell Collaboration), Paula Lopez(Campbell Collaboration), P Cox(Campbell Collaboration), Glyn Fletcher(Campbell Collaboration), Mark Wilkinson(Campbell Collaboration), Paul Fitzsimmons(Campbell Collaboration), Nikhil Sharma(Campbell Collaboration), James Choulerton(Campbell Collaboration), Denise Button(Campbell Collaboration), Lindsey Dow(Campbell Collaboration), Lukuman Gbadamoshi(Campbell Collaboration), Joanne Avis(Campbell Collaboration), B. Madigan(Campbell Collaboration), Mccann Stephanie(Campbell Collaboration), Louise Shaw(Campbell Collaboration), Deborah Howcroft(Campbell Collaboration), Suzanne Lucas(Campbell Collaboration), Andrew Stone(Campbell Collaboration), Gillian Cluckie(Campbell Collaboration), Brian Clarke(Campbell Collaboration), Natasha Clarke(Campbell Collaboration), Neha Chopra(Campbell Collaboration), Bhavini Patel(Campbell Collaboration), Kate Kennedy(Campbell Collaboration), Rebecca Williams(Campbell Collaboration), Adrian Blight(Campbell Collaboration), Joanna O’Reilly(Campbell Collaboration), Chukwuka Orefo(Campbell Collaboration), Nilofer Dayal(Campbell Collaboration), Rita Ghatala(Campbell Collaboration), Temi Adedoyin(Campbell Collaboration), Caroline Lovelock(Campbell Collaboration), Fran Watson(Campbell Collaboration), Sarah Trippier(Campbell Collaboration), Lillian Choy(Campbell Collaboration), Barry Moynihan(Campbell Collaboration), Usman Khan(Campbell Collaboration), Val Jones(Campbell Collaboration), Naomi Jeyaraj(Campbell Collaboration), Lourda Kerin(Campbell Collaboration), Kamy Thavanesan(Campbell Collaboration), Chantel Cox(Campbell Collaboration), Arshi Iqbal(Campbell Collaboration), Caroline Bagnall(Campbell Collaboration), Anja Ljubez(Campbell Collaboration), Marketa Keltos(Campbell Collaboration), Josh Roberts(Campbell Collaboration), Becky Jupp(Campbell Collaboration), Laura Tucker(Campbell Collaboration), Tanith Changuion(Campbell Collaboration), Catherine Ovington(Campbell Collaboration), Emily Rogers(Campbell Collaboration), Owen David(Campbell Collaboration), Jo Bell(Campbell Collaboration), Barbara Longland(Campbell Collaboration), Gail Hann(Campbell Collaboration), Divya Tiwari(Campbell Collaboration), Martin Cooper(Campbell Collaboration), Mohammad Nasar(Campbell Collaboration), Anoja Rajapakse(Campbell Collaboration), Inez Wynter(Campbell Collaboration), Ijaz Anwar(Campbell Collaboration), Helen Skinner(Campbell Collaboration), Tarn Nozedar(Campbell Collaboration), Damian McArdle(Campbell Collaboration), Balakrishna Kumar(Campbell Collaboration), Susan E. Crawford(Campbell Collaboration), Arunkumar Annamalai(Campbell Collaboration), Alex Ramshaw(Campbell Collaboration), Clare Holmes(Campbell Collaboration), Mairead Osborn(Campbell Collaboration), Emily Dodd(Campbell Collaboration), Peter Murphy(Campbell Collaboration), Nicola Devitt(Campbell Collaboration), Pauline Baker(Campbell Collaboration), Amy Steele(Campbell Collaboration), Lucy Belle Guthrie(Campbell Collaboration), Sarah Caine(Campbell Collaboration), Samantha Clarke(Campbell Collaboration), Ahamad Hassan(Campbell Collaboration), Dean Waugh(Campbell Collaboration), Emelda Veraque(Campbell Collaboration), Linetty Makawa(Campbell Collaboration), Mary Kambafwile(Campbell Collaboration), Marc Randall(Campbell Collaboration), Vasileios Papavasileiou(Campbell Collaboration), Claire Cullen(Campbell Collaboration), Jenny Peters(Campbell Collaboration), Thant Hlaing(Campbell Collaboration), Tanya Ingram(Campbell Collaboration), Mellor Zoe(Campbell Collaboration), Ramesh Durairaj(Campbell Collaboration), Melanie Harrison(Campbell Collaboration), Daniela Shackcloth(Campbell Collaboration), Jordan Ewing(Campbell Collaboration), Sarah Stevenson(Campbell Collaboration), Victoria Sutton(Campbell Collaboration), Mark O. McCarron(Campbell Collaboration), Jacqueline McKee(Campbell Collaboration), Mandy Doherty(Campbell Collaboration), Ferghal McVerry(Campbell Collaboration), Caroline Blair(Campbell Collaboration), Dónal Concannon(Campbell Collaboration), Mary Joan MacLeod(Campbell Collaboration), Janice Irvine(Campbell Collaboration), Heather Gow(Campbell Collaboration), Jacqueline Furnace(Campbell Collaboration), Anu Joyson(Campbell Collaboration), Baljit Jagpal(Campbell Collaboration), Sarah J. Ross(Campbell Collaboration), Katrina Klaasen(Campbell Collaboration), Beverly MacLennan(Campbell Collaboration), Sandra Nelson(Campbell Collaboration), Rebecca Clarke(Campbell Collaboration), Nichola Crouch(Campbell Collaboration), Vicky Taylor(Campbell Collaboration), Daniel Epstein(Campbell Collaboration), Avani Shukla(Campbell Collaboration), Vinodh Krishnamurthy(Campbell Collaboration), Paul Nicholas(Campbell Collaboration), Sammie Qureshi(Campbell Collaboration), Adam Webber(Campbell Collaboration), Justin Penge(Campbell Collaboration), Hawraman Ramadan(Campbell Collaboration), Stuart Maguire(Campbell Collaboration), C. C. Patterson(Campbell Collaboration), Ruth Bellfield(Campbell Collaboration), Brigid Hairsine(Campbell Collaboration), Kelvin Stewart(Campbell Collaboration), Michaela Hooley(Campbell Collaboration), Outi Quinn(Campbell Collaboration), Bella Richard(Campbell Collaboration), Sally Moseley(Campbell Collaboration), Mandy Edwards(Campbell Collaboration), Heidi Lawson(Campbell Collaboration), Michelle Tayler(Campbell Collaboration), Yogish Pai(Campbell Collaboration), Gemma Smith(Campbell Collaboration), Mark Garside(Campbell Collaboration), Mahesh Dhakal(Campbell Collaboration), Muhammad Naeem(Campbell Collaboration), Vidya Baliga(Campbell Collaboration), Gill Rogers(Campbell Collaboration), Ellen Brown(Campbell Collaboration), David Bruce(Campbell Collaboration), Susan Clayton(Campbell Collaboration), Rachel Hayman(Campbell Collaboration), Sofia Dima(Campbell Collaboration), Ed Gamble(Campbell Collaboration), Rebecca Grue(Campbell Collaboration), Bethan Charles(Campbell Collaboration), Adam Hague(Campbell Collaboration), Sujata Blane(Campbell Collaboration), Caroline Lambert(Campbell Collaboration), Afnan Chaudhry(Campbell Collaboration), Thomas S. Harrison(Campbell Collaboration), Laura Howaniec(Campbell Collaboration), Dionne Hove(Campbell Collaboration), Gemma Grimwood(Campbell Collaboration), Kari Saastamoinen(Campbell Collaboration), Ozlem Redjep(Campbell Collaboration), Fiona Humphries(Campbell Collaboration), Lucia Argandona(Campbell Collaboration), Esther Erumere(Campbell Collaboration), Sageet Amlani(Campbell Collaboration), Grace Auld(Campbell Collaboration), Afraim Salek‐Haddadi(Campbell Collaboration), Ursula G. Schulz(Campbell Collaboration), Philip Mathieson(Campbell Collaboration), Ian Reckless(Campbell Collaboration), James Kennedy(Campbell Collaboration), Gary A. Ford(Campbell Collaboration), Rachel Teal(Campbell Collaboration), Giulia Lenti(Campbell Collaboration), George Harston(Campbell Collaboration), Eoin OʼBrien(Campbell Collaboration), Sarah Finlay(Campbell Collaboration), Helen Hayhoe(Campbell Collaboration), Sarah Crisp(Campbell Collaboration), Juliana Sesay(Campbell Collaboration), George Zachariah(Campbell Collaboration), Jobbin Francis(Campbell Collaboration), Dominic Handley(Campbell Collaboration), Siobhán Kelly(Campbell Collaboration), Joanne McGee(Campbell Collaboration), Jennifer Mitchell(Campbell Collaboration), Elaine Amis(Campbell Collaboration), Niamh Hannon(Campbell Collaboration), Tom Hughes(Campbell Collaboration), Bethan Morse(Campbell Collaboration), Henry de Berker(Campbell Collaboration), Susan White(Campbell Collaboration), Emma Tallantyre(Campbell Collaboration), Ahmed Osman(Campbell Collaboration), Lucy Knibbs(Campbell Collaboration), Stefan Schwarz(Campbell Collaboration), Benjamin Jelley(Campbell Collaboration), Rajendra Yadava(Campbell Collaboration), Julie Reddan(Campbell Collaboration), Mirriam Sangombe(Campbell Collaboration), Khalid Azhar(Campbell Collaboration), Samantha Stafford(Campbell Collaboration), Nasar Ahmad(Campbell Collaboration), K. Fotherby(Campbell Collaboration), Debbie Morgan(Campbell Collaboration), Farrukh Baig(Campbell Collaboration), Karla Jennings-Preece(Campbell Collaboration), Donna Butler(Campbell Collaboration), Baljinder Rai(Campbell Collaboration), Angela Willberry(Campbell Collaboration), Angela Stevens(Campbell Collaboration), Prasad Siddegowda(Campbell Collaboration), Lisa Hyatt(Campbell Collaboration), Peter Howard(Campbell Collaboration), David Jarrett(Campbell Collaboration), S. Ponnambath(Campbell Collaboration), Tracey Dobson(Campbell Collaboration), Jane Tandy(Campbell Collaboration), Claire James(Campbell Collaboration), Stacey L. Valentine(Campbell Collaboration), Yasmin Harrington-Davies(Campbell Collaboration), Rebecca K. Butler(Campbell Collaboration), Anne Suttling(Campbell Collaboration), Fiona Wright(Campbell Collaboration), G.R. Kerr(Campbell Collaboration), Ruth Graham(Campbell Collaboration), Christine McAlpine(Campbell Collaboration), Peter Langhorne(Campbell Collaboration), Mohammad Shahzad Iqbal(Campbell Collaboration), Louise Humphreys(Campbell Collaboration), Kath Pasco(Campbell Collaboration), Olga Balazikova(Campbell Collaboration), Ashraf Nasim(Campbell Collaboration), Cassilda Peixoto(Campbell Collaboration), Louise Gallagher(Campbell Collaboration), Shahrzad Shahmehri(Campbell Collaboration), Sandip Ghosh(Campbell Collaboration), Elizabeth S. Barrie(Campbell Collaboration), Danielle Gilmour(Campbell Collaboration), Margo Henry(Campbell Collaboration), Tom Webb(Campbell Collaboration), Linda Cowie(Campbell Collaboration), Hannah Rudenko(Campbell Collaboration), Natasha Schumacher(Campbell Collaboration), Shanni McDonald(Campbell Collaboration), Susannah B. Walker(Campbell Collaboration), Tracey Cosier(Campbell Collaboration), Anna Verrion(Campbell Collaboration), Eva Beranová(Campbell Collaboration), Audrey Thomson(Campbell Collaboration), Marius Venter(Campbell Collaboration), Sheila Mashate(Campbell Collaboration), Kirsten Harvey(Campbell Collaboration), Léjeune Gardener(Campbell Collaboration), Vinh Nguyen(Campbell Collaboration), Omid Halse(Campbell Collaboration), Olivia Geraghty(Campbell Collaboration), Beth Hazel(Campbell Collaboration), Peter Wilding(Campbell Collaboration), Victoria Tilley(Campbell Collaboration), Arindam Kar(Campbell Collaboration), Louise Southern(Campbell Collaboration), Tim Cassidy(Campbell Collaboration), Bernard Esisi(Campbell Collaboration), Beverley McClelland(Campbell Collaboration), Maria Bokhari(Campbell Collaboration), Timothy J. England(Campbell Collaboration), Mohana Maddula(Campbell Collaboration), Richard Donnelly(Campbell Collaboration), Paul Findlay(Campbell Collaboration), Ian Shread(Campbell Collaboration), Ashish Macaden(Campbell Collaboration), Charlotte Barr(Campbell Collaboration), Azlisham Mohd Nor(Campbell Collaboration), Nicola Persad(Campbell Collaboration), Charlotte Eglinton(Campbell Collaboration), Marie Weinling(Campbell Collaboration), Claire Brown(Campbell Collaboration), Benjamin Hyams(Campbell Collaboration), Alex Shah(Campbell Collaboration), John G. Baker(Campbell Collaboration), Anthony Byrne(Campbell Collaboration), Caroline McGhee(Campbell Collaboration), Amanda Smart(Campbell Collaboration), Claire Copeland(Campbell Collaboration), Michael D. Carpenter(Campbell Collaboration), Marion Walker(Campbell Collaboration), Richard Davey(Campbell Collaboration), Ann Needle(Campbell Collaboration), Razik Fathima(Campbell Collaboration), Gavin Bateman(Campbell Collaboration), Andrew Stanners(Campbell Collaboration), Prabal Datta(Campbell Collaboration), Linda Jackson(Campbell Collaboration), Julie Ball(Campbell Collaboration), Michelle Davis(Campbell Collaboration), Natalie Atkinson(Campbell Collaboration), Michelle Fawcett(Campbell Collaboration), Teresa Thompson(Campbell Collaboration), Helen Guy(Campbell Collaboration), Valerie Hogg(Campbell Collaboration), Carole Hays(Campbell Collaboration), Stephen Woodward(Campbell Collaboration), Mohammad Haque(Campbell Collaboration), Stuart Symonds(Campbell Collaboration), Mehran Maanoosi(Campbell Collaboration), Jane Herman(Campbell Collaboration), Toby Black(Campbell Collaboration), Caroline S. Clarke(Campbell Collaboration), Skelton Miriam(Campbell Collaboration), Alpha Anthony(Campbell Collaboration), Michele Tribbeck(Campbell Collaboration), Julie Cronin(Campbell Collaboration), Denise Mead(Campbell Collaboration), R Fennelly(Campbell Collaboration), James McIlmoyle(Campbell Collaboration), Christina Dickinson(Campbell Collaboration), Carol Jeffs(Campbell Collaboration), Joanne Howard(Campbell Collaboration), Sajjad Anwar(Campbell Collaboration), Kirsty Jones(Campbell Collaboration), Saikat Dhar(Campbell Collaboration), Muhammad Siddiq(Campbell Collaboration), Caroline Clay(Campbell Collaboration), Simone Ivatts(Campbell Collaboration), Yolanda Baird(Campbell Collaboration), Sally Moore(Campbell Collaboration), Lisa Clayton- Evans(Campbell Collaboration), Sophie Newton(Campbell Collaboration), Isobel Amey(Campbell Collaboration), Indra Chadbourn(Campbell Collaboration), Rayessa Rayessa(Campbell Collaboration), Lisa M Wilson(Campbell Collaboration), Alicia Rodgers(Campbell Collaboration), Charde Naylor(Campbell Collaboration), Sarah L. Wilson(Campbell Collaboration), Emma Clarkson(Campbell Collaboration), Ruth Davies(Campbell Collaboration), Paula Owings(Campbell Collaboration), Graeme Sangster(Campbell Collaboration), Valerie Gott(Campbell Collaboration), Victoria Little(Campbell Collaboration), Pauline Weir(Campbell Collaboration), Suja Cherian(Campbell Collaboration), Deepa Jose(Campbell Collaboration), Helen Moroney(Campbell Collaboration), Susan Downham(Campbell Collaboration), Angela Dodd(Campbell Collaboration), Venetia Vettimootal Johnson(Campbell Collaboration), Laura Codd(Campbell Collaboration), Naomi Robinson(Campbell Collaboration), Ashraf Ahmed(Campbell Collaboration), Sharon A. Johnson(Campbell Collaboration), Carol Denniss(Campbell Collaboration), Mo Albazzaz(Campbell Collaboration), Mishell Cunningham(Campbell Collaboration), Tajammal Zahoor(Campbell Collaboration), Timothy Webster(Campbell Collaboration), Sandra Leason(Campbell Collaboration), Syed Haider(Campbell Collaboration), Kausik Chatterjee(Campbell Collaboration), Arumugam Nallasivan(Campbell Collaboration), Charlotte Perkins(Campbell Collaboration), Samantha Seagrave(Campbell Collaboration), Colin Jenkins(Campbell Collaboration), Fiona Price(Campbell Collaboration), Claire Hughes(Campbell Collaboration), Lily Mercer(Campbell Collaboration), Malik Azhar Hussain(Campbell Collaboration), Sarah Brown(Campbell Collaboration), Miriam Harvey(Campbell Collaboration), Robert F. Whiting(Campbell Collaboration), Mohammad Faizan Khan(Campbell Collaboration), Jane Homan(Campbell Collaboration), Leanne Foote(Campbell Collaboration), Nicholas Hunt(Campbell Collaboration), Helen Durman(Campbell Collaboration), Lucy Brotherton(Campbell Collaboration), Jayne Foot(Campbell Collaboration), Corinne Pawley(Campbell Collaboration), Eliza Foster(Campbell Collaboration), Alison Whitcher(Campbell Collaboration), Kneale Metcalf(Campbell Collaboration), Jenny Jagger(Campbell Collaboration), Susan A. McDonald(Campbell Collaboration), Kelly Waterfield(Campbell Collaboration), Patrick Sutton(Campbell Collaboration), Naval Shinh(Campbell Collaboration), Ajmal Anversha(Campbell Collaboration), Garth Ravenhill(Campbell Collaboration), Richard Greenwood(Campbell Collaboration), Janak Saada(Campbell Collaboration), Alison Wiltshire(Campbell Collaboration), Rebekah Perfitt(Campbell Collaboration), Magdalini Krommyda(Campbell Collaboration), Evelyne Burssens(Campbell Collaboration), Naveen Gadapa(Campbell Collaboration), Karen Dunne(Campbell Collaboration), Sreeman Andole(Campbell Collaboration), Sam King(Campbell Collaboration), Catherine Plewa(Campbell Collaboration), Nigel Smyth(Campbell Collaboration), J. Wilson(Campbell Collaboration), Elio Giallombardo(Campbell Collaboration), Lucy Sykes(Campbell Collaboration), Pradeep Kumar(Campbell Collaboration), James L. Barker(Campbell Collaboration), Linda Dunn(Campbell Collaboration), Isabel Huggett(Campbell Collaboration), Charlotte Culmsee(Campbell Collaboration), Philip Thomas(Campbell Collaboration), Min Myint(Campbell Collaboration), Helen Brew(Campbell Collaboration), Nikhil Majmudar(Campbell Collaboration), Janice O’Connell(Campbell Collaboration), George Bunea(Campbell Collaboration), Charlotte Fox(Campbell Collaboration), Diane Gulliver(Campbell Collaboration), Andrew Smith(Campbell Collaboration), Betty Mokoena(Campbell Collaboration), Naweed Sattar(Campbell Collaboration), Ramesh Krishnamurthy(Campbell Collaboration), E Osborne(Campbell Collaboration), David H. Wilson(Campbell Collaboration), Belinda Wroath(Campbell Collaboration), Kevin Dynan(Campbell Collaboration), Mick Power(Campbell Collaboration), Susan Thompson(Campbell Collaboration), Victoria Adell(Campbell Collaboration), Enoch Orugun(Campbell Collaboration), Una Poultney(Campbell Collaboration), Rachel Glover(Campbell Collaboration), Hannah Crowther(Campbell Collaboration), Sarah Thornthwaite(Campbell Collaboration), Ivan Wiggam(Campbell Collaboration), Aine Wallace(Campbell Collaboration), Enda Kerr(Campbell Collaboration), Ailsa Fulton(Campbell Collaboration), Annemarie Hunter(Campbell Collaboration), Suzanne Tauro(Campbell Collaboration), Sarah Cuddy(Campbell Collaboration), David Mangion(Campbell Collaboration), Skarlet Markova(Campbell Collaboration), Anne Hardwick(Campbell Collaboration), Tara Lawrence(Campbell Collaboration), Carmen Constantin(Campbell Collaboration), Jo Fletecher(Campbell Collaboration), Isobel Thomas(Campbell Collaboration), Kerry Pettitt(Campbell Collaboration), Lakshmanan Sekaran(Campbell Collaboration), Frances Justin(Campbell Collaboration), Margaret Tate(Campbell Collaboration), Kiranjit Bharaj(Campbell Collaboration), Rohan Simon(Campbell Collaboration), Niaz Mohammed(Campbell Collaboration), Sakthivel Sethuraman(Campbell Collaboration), Duke Phiri(Campbell Collaboration), Meena Chauhan(Campbell Collaboration), Khaled Elfandi(Campbell Collaboration), Uzma Khan(Campbell Collaboration), D. Eveson(Campbell Collaboration), Amit Mistri(Campbell Collaboration), Lisa Manning(Campbell Collaboration), Shagufta Khan(Campbell Collaboration), Champa Patel(Campbell Collaboration), Mohammed Moqsith(Campbell Collaboration), Saira Sattar(Campbell Collaboration), Man Y. Lam(Campbell Collaboration), Kashif Musarrat(Campbell Collaboration), Claire Stephens(Campbell Collaboration), Latheef Kalathil(Campbell Collaboration), Richard Miller(Campbell Collaboration), Maqsud Salehin(Campbell Collaboration), Nikki Gautam(Campbell Collaboration), Duncan Bailey(Campbell Collaboration), Amor Kelly(Campbell Collaboration), Julie Meir(Campbell Collaboration), Javed Imam(Campbell Collaboration), Lisa J. Wood(Campbell Collaboration), Anne Nicolson(Campbell Collaboration), Julie White(Campbell Collaboration), Mahmud Sajid(Campbell Collaboration), George Ghaly(Campbell Collaboration), Margaret Ball(Campbell Collaboration), Rachel Gascoyne(Campbell Collaboration), Harald Proeschel(Campbell Collaboration), Simon Sharpe(Campbell Collaboration), Sarah Horton(Campbell Collaboration), Emily Beaves(Campbell Collaboration), Stephanie Jones(Campbell Collaboration), Brigitte Yip(Campbell Collaboration), Murdina Bell(Campbell Collaboration), Linda MacLiver(Campbell Collaboration), Brian MacInnes(Campbell Collaboration), Don Sims(Campbell Collaboration), Jennifer Hurley(Campbell Collaboration), Mark Willmot(Campbell Collaboration), Claire Sutton(Campbell Collaboration), Edward Littleton(Campbell Collaboration), Susan Maiden(Campbell Collaboration), Rachael Jones(Campbell Collaboration), James Cunningham(Campbell Collaboration), Carole Green(Campbell Collaboration), Michelle Bates(Campbell Collaboration), Raj Shekhar(Campbell Collaboration), Ellie Gilham(Campbell Collaboration), Iman Ahmed(Campbell Collaboration), R. M. Crown(Campbell Collaboration), Tracy Fuller(Campbell Collaboration), Neetish Goorah(Campbell Collaboration), Angela Bell(Campbell Collaboration), Christine Kelly(Campbell Collaboration), Arun Singh(Campbell Collaboration), Jamie Walford(Campbell Collaboration), Benjamin Tomlinson(Campbell Collaboration), Farzana Patel(Campbell Collaboration), Stephen Duberley(Campbell Collaboration), Ingrid Kane(Campbell Collaboration), Nicola Gainsborough(Campbell Collaboration), Chakravarthi Rajkumar(Campbell Collaboration), Jane Gaylard(Campbell Collaboration), Joanna Breeds(Campbell Collaboration), Alexandra Pitt-Ford(Campbell Collaboration), Emma Barbon(Campbell Collaboration), Laura Latter(Campbell Collaboration), Philip Thompson(Campbell Collaboration), Simon Hervey(Campbell Collaboration), Joseph A. Vassallo(Campbell Collaboration), Shrivakumar Krishnamoorthy(Campbell Collaboration), Deborah Walter(Campbell Collaboration), Helen Cochrane(Campbell Collaboration), Meena Srinivasan(Campbell Collaboration), Robert R. Campbell(Campbell Collaboration), Denise Donaldson(Campbell Collaboration), Nichola Motherwell(Campbell Collaboration), Frances Hurford(Campbell Collaboration), Indranil Mukherjee(Campbell Collaboration), Antony Kenton(Campbell Collaboration), Sheila Nyabadza(Campbell Collaboration), Irene Martín de Miguel(Campbell Collaboration), Benjamin Hunt(Campbell Collaboration), Hardi Hassan(Campbell Collaboration), Bander Dallol(Campbell Collaboration), Sarah O’Toole(Campbell Collaboration), Janet Putterill(Campbell Collaboration), Ratneshwari Jha(Campbell Collaboration), Rachel Gallifent(Campbell Collaboration), Puneet Kakar(Campbell Collaboration), Aparna Pusalkar(Campbell Collaboration), Kelly Chan(Campbell Collaboration), Puneet Dangri(Campbell Collaboration), Hannah Beadle(Campbell Collaboration), Angela Cook(Campbell Collaboration), Karen Crabtree(Campbell Collaboration), Santhosh Subramonian(Campbell Collaboration), Natalie Temple(Campbell Collaboration), Peter Owusu‐Agyei(Campbell Collaboration), Nicola Butterworth‐Cowin(Campbell Collaboration), Suzanne Ragab(Campbell Collaboration), Kerstin Knops(Campbell Collaboration), E. M. Jinks(Campbell Collaboration), Judith Dube(Campbell Collaboration), Christine Dickson(Campbell Collaboration), Laura Gleave(Campbell Collaboration), Jacqui Leggett(Campbell Collaboration), Tatiana Garcia(Campbell Collaboration), Sissy Ispoglou(Campbell Collaboration), Rachel Evans(Campbell Collaboration), Sandeep Ankolekar(Campbell Collaboration), Anne Hayes(Campbell Collaboration), Hlaing Ni(Campbell Collaboration), Josette Milligan(Campbell Collaboration), Bithi Rahman(Campbell Collaboration), Carol Graham(Campbell Collaboration), Josin Jose(Campbell Collaboration), Breffni Keegan(Campbell Collaboration), Jim Kelly(Campbell Collaboration), James R. White(Campbell Collaboration), Kelly Thomas(Campbell Collaboration), Lisa Mellish(Campbell Collaboration), Richard Dewar(Campbell Collaboration)
JAMA Neurology
September 3, 2021
10.1001/jamaneurol.2021.2956
Cited by 48Open Access
Full Text

Abstract

Importance: The Restart or Stop Antithrombotics Randomized Trial (RESTART) found that antiplatelet therapy appeared to be safe up to 5 years after intracerebral hemorrhage (ICH) that had occurred during antithrombotic (antiplatelet or anticoagulant) therapy. Objectives: To monitor adherence, increase duration of follow-up, and improve precision of estimates of the effects of antiplatelet therapy on recurrent ICH and major vascular events. Design, Setting and Participants: From May 22, 2013, through May 31, 2018, this prospective, open, blinded end point, parallel-group randomized clinical trial studied 537 participants at 122 hospitals in the UK. Participants were individuals 18 years or older who had taken antithrombotic therapy for the prevention of occlusive vascular disease when they developed ICH, discontinued antithrombotic therapy, and survived for 24 hours. After initial follow-up ended on November 30, 2018, annual follow-up was extended until November 30, 2020, for a median of 3.0 years (interquartile range [IQR], 2.0-5.0 years) for the trial cohort. Interventions: Computerized randomization that incorporated minimization allocated participants (1:1) to start or avoid antiplatelet therapy. Main Outcomes and Measures: Participants were followed up for the primary outcome (recurrent symptomatic ICH) and secondary outcomes (all major vascular events) for up to 7 years. Data from all randomized participants were analyzed using Cox proportional hazards regression, adjusted for minimization covariates. Results: A total of 537 patients (median age, 76.0 years; IQR, 69.0-82.0 years; 360 [67.0%] male; median time after ICH onset, 76.0 days; IQR, 29.0-146.0 days) were randomly allocated to start (n = 268) or avoid (n = 269 [1 withdrew]) antiplatelet therapy. The primary outcome of recurrent ICH affected 22 of 268 participants (8.2%) allocated to antiplatelet therapy compared with 25 of 268 participants (9.3%) allocated to avoid antiplatelet therapy (adjusted hazard ratio, 0.87; 95% CI, 0.49-1.55; P = .64). A major vascular event affected 72 participants (26.8%) allocated to antiplatelet therapy compared with 87 participants (32.5%) allocated to avoid antiplatelet therapy (hazard ratio, 0.79; 95% CI, 0.58-1.08; P = .14). Conclusions and Relevance: Among patients with ICH who had previously taken antithrombotic therapy, this study found no statistically significant effect of antiplatelet therapy on recurrent ICH or all major vascular events. These findings provide physicians with some reassurance about the use of antiplatelet therapy after ICH if indicated for secondary prevention of major vascular events. Trial Registration: isrctn.org Identifier: ISRCTN71907627.

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