Toby Black

Background: Previous studies suggested potential ethnic differences in the management and outcomes of atrial fibrillation (AF). We aim to analyse oral anticoagulant (OAC) prescription, discontinuation, and risk of adverse outcomes in Asian patients with AF, using data from a global prospective cohort study. Methods: From the GLORIA-AF Registry Phase II-III (November 2011-December 2014 for Phase II, and January 2014-December 2016 for Phase III), we analysed patients according to their self-reported ethnicity (Asian vs. non-Asian), as well as according to Asian subgroups (Chinese, Japanese, Korean and other Asian). Logistic regression was used to analyse OAC prescription, while the risk of OAC discontinuation and adverse outcomes were analysed through Cox-regression model. Our primary outcome was the composite of all-cause death and major adverse cardiovascular events (MACE). The original studies were registered with ClinicalTrials.gov, NCT01468701, NCT01671007, and NCT01937377. Findings: 34,421 patients were included (70.0 ± 10.5 years, 45.1% females, 6900 (20.0%) Asian: 3829 (55.5%) Chinese, 814 (11.8%) Japanese, 1964 (28.5%) Korean and 293 (4.2%) other Asian). Most of the Asian patients were recruited in Asia (n = 6701, 97.1%), while non-Asian patients were mainly recruited in Europe (n = 15,449, 56.1%) and North America (n = 8378, 30.4%). Compared to non-Asian individuals, prescription of OAC and non-vitamin K antagonist oral anticoagulant (NOAC) was lower in Asian patients (Odds Ratio [OR] and 95% Confidence Intervals (CI): 0.23 [0.22-0.25] and 0.66 [0.61-0.71], respectively), but higher in the Japanese subgroup. Asian ethnicity was also associated with higher risk of OAC discontinuation (Hazard Ratio [HR] and [95% CI]: 1.79 [1.67-1.92]), and lower risk of the primary composite outcome (HR [95% CI]: 0.86 [0.76-0.96]). Among the exploratory secondary outcomes, Asian ethnicity was associated with higher risks of thromboembolism and intracranial haemorrhage, and lower risk of major bleeding. Interpretation: Our results showed that Asian patients with AF showed suboptimal thromboembolic risk management and a specific risk profile of adverse outcomes; these differences may also reflect differences in country-specific factors. Ensuring integrated and appropriate treatment of these patients is crucial to improve their prognosis. Funding: The GLORIA-AF Registry was funded by Boehringer Ingelheim GmbH.

Book Review| Online March 01 1983 Children with Disabilities and Their Families Children with Disabilities and Their Families. , Mark Philp, Derek Duckworth. Humanities Press, Inc., Atlantic Highlands, NJ 07716, 131 pp ( 1982), $14.75, paper. Toby Joanne Black, OTR Toby Joanne Black, OTR Search for other works by this author on: This Site PubMed Google Scholar Author & Article Information Online ISSN: 1943-7676 Print ISSN: 0272-9490 Copyright © 1983 by the American Occupational Therapy Association, Inc.1983 The American Journal of Occupational Therapy, 1983, Vol. 37(3), 208. https://doi.org/10.5014/ajot.37.3.208b Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Toby Joanne Black; Children with Disabilities and Their Families. Am J Occup Ther March 1983, Vol. 37(3), 208. doi: https://doi.org/10.5014/ajot.37.3.208b Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentThe American Journal of Occupational Therapy Search Advanced Search This content is only available via PDF. Copyright © 1983 by the American Occupational Therapy Association, Inc.1983 Article PDF first page preview Close Modal You do not currently have access to this content.

Book Review| Online August 01 1984 Public School Integration of Severely Handicapped Students Public School Integration of Severely Handicapped Students. , Nick Certo, Norris Haring, and Robert York, Editors. Paul H. Brookes Publishing Co., P. O. Box 10624, Baltimore, MD 21204, 331 pp ( 1984) $18.95. Toby Joanne Black, OTR Toby Joanne Black, OTR Search for other works by this author on: This Site PubMed Google Scholar Author & Article Information Online ISSN: 1943-7676 Print ISSN: 0272-9490 Copyright © 1984 by the American Occupational Therapy Association, Inc.1984 The American Journal of Occupational Therapy, 1984, Vol. 38(8), 549–550. https://doi.org/10.5014/ajot.38.8.549c Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Toby Joanne Black; Public School Integration of Severely Handicapped Students. Am J Occup Ther August 1984, Vol. 38(8), 549–550. doi: https://doi.org/10.5014/ajot.38.8.549c Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentThe American Journal of Occupational Therapy Search Advanced Search This content is only available via PDF. Copyright © 1984 by the American Occupational Therapy Association, Inc.1984 Article PDF first page preview Close Modal You do not currently have access to this content.

Book Review| Online August 01 1986 Neurobehavioral and Perceptual Dysfunction in Learning Disabled Children Neurobehavioral and Perceptual Dysfunction in Learning Disabled Children. Demont C. Morrison ( 1985). C.J. Hogrefe, Inc., PO Box 51, Lewiston, NY 14092. 176 pp. Toby Joanne Black Toby Joanne Black Search for other works by this author on: This Site PubMed Google Scholar Author & Article Information Online ISSN: 1943-7676 Print ISSN: 0272-9490 Copyright © 1986 by the American Occupational Therapy Association, Inc.1986 The American Journal of Occupational Therapy, 1986, Vol. 40(8), 576. https://doi.org/10.5014/ajot.40.8.576a Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Toby Joanne Black; Neurobehavioral and Perceptual Dysfunction in Learning Disabled Children. Am J Occup Ther August 1986, Vol. 40(8), 576. doi: https://doi.org/10.5014/ajot.40.8.576a Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentThe American Journal of Occupational Therapy Search Advanced Search This content is only available via PDF. Copyright © 1986 by the American Occupational Therapy Association, Inc.1986 Article PDF first page preview Close Modal You do not currently have access to this content.

BACKGROUND AND PURPOSE: There is limited evidence for remote stroke thrombolysis using telephone consultation and teleradiology. Results from a UK network using this treatment model are presented. METHODS: Retrospective study of consecutive patients thrombolysed in 5 hospitals, with well organized stroke services, between 2012 and 2013. Remote thrombolysis was compared with thrombolysis delivered in person for symptomatic intracerebral hemorrhage, death within 7 days, and 90-day modified Rankin scores. RESULTS: Of 586 patients, 220 (37.5%) were thrombolysed remotely. The 2 groups were well matched (median age 77 years, NIHSS 12). Remote thrombolysis increased treatment time by 22 minutes. Outcomes were no different in the 2 groups (remote versus standard): symptomatic intracerebral hemorrhage (3.6% versus 4.6%), death within 7 days (6.4% versus 7.1%), modified Rankin score <2 (46.0% versus 46.1%), and modified Rankin score 6 (15% versus 17.5%) at 90 days. CONCLUSION: Telephone advice and teleradiology, within an organized system of care, can be an effective method of delivery of intravenous thrombolysis.