Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

Divij Mathew(Translational Therapeutics (United States)), Josephine R. Giles(Parker Institute for Cancer Immunotherapy), Amy E. Baxter(Translational Therapeutics (United States)), Derek A. Oldridge(University of Pennsylvania), Allison R. Greenplate(Translational Therapeutics (United States)), Jennifer E. Wu(Parker Institute for Cancer Immunotherapy), Cécile Alanio(Parker Institute for Cancer Immunotherapy), Leticia Kuri-Cervantes(University of Pennsylvania), M. Betina Pampena(University of Pennsylvania), Kurt D’Andrea(Translational Therapeutics (United States)), Sasikanth Manne(Translational Therapeutics (United States)), Zeyu Chen(Translational Therapeutics (United States)), Yinghui Huang(Translational Therapeutics (United States)), John P. Reilly(University of Pennsylvania), Ariel R. Weisman(University of Pennsylvania), C.A.G. Ittner(University of Pennsylvania), Oliva Kuthuru(Translational Therapeutics (United States)), Jeanette Dougherty(Translational Therapeutics (United States)), Kito Nzingha(Translational Therapeutics (United States)), Nicholas Han(Translational Therapeutics (United States)), Justin Kim(Translational Therapeutics (United States)), Ajinkya Pattekar(University of Pennsylvania), Eileen C. Goodwin(University of Pennsylvania), Elizabeth M. Anderson(University of Pennsylvania), Madison E. Weirick(University of Pennsylvania), Sigrid Gouma(University of Pennsylvania), Claudia P. Arevalo(University of Pennsylvania), Marcus J. Bolton(University of Pennsylvania), Chen Fang(University of Pennsylvania), Simon F. Lacey(University of Pennsylvania), Holly Ramage(Thomas Jefferson University), Sara Cherry(University of Pennsylvania), Scott E. Hensley(University of Pennsylvania), Sokratis A. Apostolidis(University of Pennsylvania), Alexander C. Huang(Parker Institute for Cancer Immunotherapy), Laura A. Vella(Children's Hospital of Philadelphia), The UPenn COVID Processing Unit(University of Pennsylvania), Michael R. Betts(University of Pennsylvania), Nuala J. Meyer(Parker Institute for Cancer Immunotherapy), E. John Wherry(Parker Institute for Cancer Immunotherapy), Zahidul Alam, Mary M. Addison, Katelyn T. Byrne, Aditi Chandra, Hélène C. Descamps, Yaroslav Kaminskiy, Jacob T. Hamilton, Julia Han Noll, Dalia K. Omran, Eric Perkey(University of Pennsylvania), Elizabeth M. Prager, Dana Pueschl, Jennifer Shah, Jake Shilan, Ashley Vanderbeck
Science
July 15, 2020
10.1126/science.abc8511
Cited by 1,652Open Access
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Abstract

Immune profiling of COVID-19 patients Coronavirus disease 2019 (COVID-19) has affected millions of people globally, yet how the human immune system responds to and influences COVID-19 severity remains unclear. Mathew et al. present a comprehensive atlas of immune modulation associated with COVID-19. They performed high-dimensional flow cytometry of hospitalized COVID-19 patients and found three prominent and distinct immunotypes that are related to disease severity and clinical parameters. Arunachalam et al. report a systems biology approach to assess the immune system of COVID-19 patients with mild-to-severe disease. These studies provide a compendium of immune cell information and roadmaps for potential therapeutic interventions. Science , this issue p. eabc8511 , p. 1210

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