Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

Gideon Bollag; Peter Hirth; James Tsai; Jiazhong Zhang; Prabha N. Ibrahim; Hanna Cho; Wayne Spevak; Chao Zhang; Ying Zhang; Gaston Habets; Elizabeth A. Burton; Bernice H. Wong; Garson Tsang; Brian L. West; Ben Powell; Rafe Shellooe; Adhirai Marimuthu; Hoa Nguyen; Kam Y. J. Zhang; Dean R. Artis; Joseph Schlessinger; Fei Su; Brian Higgins; Raman Iyer; Kurt D’Andrea; Astrid Koehler; Michael Stumm; Paul Lin; Richard J. Lee; Joseph F. Grippo; Igor Puzanov; Kevin B. Kim; Antoni Ribas; Grant A. McArthur; Jeffrey A. Sosman; Paul B. Chapman; Keith T. Flaherty; Xiaowei Xu; Katherine L. Nathanson; K. B. Nolop

doi:10.1038/nature09454

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

Gideon Bollag(Universidad Estatal de Bolívar), Peter Hirth(Plexxikon (United States)), James Tsai(Plexxikon (United States)), Jiazhong Zhang(Plexxikon (United States)), Prabha N. Ibrahim(Plexxikon (United States)), Hanna Cho(Plexxikon (United States)), Wayne Spevak(Plexxikon (United States)), Chao Zhang(Plexxikon (United States)), Ying Zhang(Plexxikon (United States)), Gaston Habets(Plexxikon (United States)), Elizabeth A. Burton(Plexxikon (United States)), Bernice H. Wong(Plexxikon (United States)), Garson Tsang(Plexxikon (United States)), Brian L. West(Plexxikon (United States)), Ben Powell(Plexxikon (United States)), Rafe Shellooe(Plexxikon (United States)), Adhirai Marimuthu(Plexxikon (United States)), Hoa Nguyen(Plexxikon (United States)), Kam Y. J. Zhang(Plexxikon (United States)), Dean R. Artis(Plexxikon (United States)), Joseph Schlessinger(Yale University), Fei Su(Kingsley House), Brian Higgins(Kingsley House), Raman Iyer(Kingsley House), Kurt D’Andrea(University of Pennsylvania), Astrid Koehler(Kingsley House), Michael Stumm(Kingsley House), Paul Lin(Plexxikon (United States)), Richard J. Lee(Kingsley House), Joseph F. Grippo(Kingsley House), Igor Puzanov(Vanderbilt University), Kevin B. Kim(The University of Texas MD Anderson Cancer Center), Antoni Ribas(University of California, Los Angeles), Grant A. McArthur(Peter MacCallum Cancer Centre), Jeffrey A. Sosman(Vanderbilt University), Paul B. Chapman(Memorial Sloan Kettering Cancer Center), Keith T. Flaherty(University of Pennsylvania), Xiaowei Xu(University of Pennsylvania), Katherine L. Nathanson(University of Pennsylvania), K. B. Nolop(Plexxikon (United States))

Nature

September 1, 2010

10.1038/nature09454

Cited by 1,821

Abstract

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