Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial
Rustam Al‐Shahi Salman(University of Edinburgh), David Minks(Newcastle upon Tyne Hospital), Dipayan Mitra(Newcastle upon Tyne Hospital), Mark Rodrigues(University of Edinburgh), Priya Bhatnagar(Newcastle upon Tyne Hospital), Johann C du Plessis(NHS Lothian), Yogish Joshi(Addenbrooke's Hospital), Martin Dennis(University of Edinburgh), Gordon Murray(University of Edinburgh), David E. Newby(University of Edinburgh), Peter Sandercock(University of Edinburgh), Nikola Sprigg(University of Nottingham), Jacqueline Stephen(University of Edinburgh), Cathie Sudlow(University of Edinburgh), David J. Werring(National Hospital for Neurology and Neurosurgery), William Whiteley(University of Edinburgh), Joanna M. Wardlaw(UK Dementia Research Institute), Phil White(Newcastle upon Tyne Hospital), Colin Baigent, Daniel Lasserson, Frank Sullivan, Johanna Carrie, Javier Rojas, Shannon Amoils, John Bamford, Jane Armitage, Gabriel Rinkel, Gordon Lowe(University of Edinburgh), Jonathan Emberson, Karen Innes, Lynn Dinsmore, Jonathan Drever, Carol Williams, David Perry(National Hospital for Neurology and Neurosurgery), Connor McGill, David L. Buchanan(National Hospital for Neurology and Neurosurgery), Allan Walker, Aidan Hutchison, Christopher R. Matthews, Ruth Fraser, Aileen McGrath, Ann Deary(UK Dementia Research Institute), Rosemary Anderson, Pauli Walker, Christian Holm Hansen, Richard Parker, Aryelly Rodríguez, Malcolm Macleod, Thomas Gattringer, Jeb Palmer, Eleni Sakka, Jennifer Adil-Smith, David Minks(Newcastle upon Tyne Hospital), Dipayan Mitra(Newcastle upon Tyne Hospital), Priya Bhatnagar(Newcastle upon Tyne Hospital), Johan du Plessis(NHS Lothian), Yogish Joshi(Addenbrooke's Hospital), Christine Lerpiniere, Richard O’Brien, Seona Burgess, Gillian Mead, Ruth Paulton, Fergus Doubal, Katrina McCormick, Neil Hunter, Pat Taylor, Ruwan Parakramawansha, Jack Perry, Gordon W. Blair(University of Edinburgh), Allan MacRaild, Adrian Parry‐Jones, Mary Johnes, Stephanie J. Lee, Kelly Marie Shaw, Ilse Burger, Martin Punter(University of Edinburgh), Andrea Ingham, Jane Perez, Zin Naing, Jordi Morell, Tracy Marsden, Andrea C. Hall, Sally J. Marshall, Louise Harrison, R. Jarapa, Edith Wood, V. O'Loughlin, David Cohen(National Hospital for Neurology and Neurosurgery), Silvie Davies, Kelechi Njoku, Mushiya Mpelembue, Laura Burgess, Radim Líčeník, Mmua Ngwako, Nabeela Nisar, Rangah Niranchanan, Tatjana Roganova, Rajaram Bathula, Joseph E. Devine, Anette David(National Hospital for Neurology and Neurosurgery), Anne Oshodi, Fenglin Guo, Emmanuelle Owoyele, Varthi Sukdeo, ROBERT I. W. BALLANTINE, Mudhar Abbdul-saheb, Angela Chamberlain, Aberami Chandrakumar, Philip Poku(Newcastle upon Tyne Hospital), Kirsty Harkness, Catrin Blank, Emma Richards, Ali Ali, Faith Kibutu, O. Yu. Balitska, Kathryn Birchall, Pauline Bayliss, Clare Doyle, Kathy Stocks, Arshad Majis, Jo Howe(UK Dementia Research Institute), Christine Kamara, Luke Barron, Ahmad Maatouk, Ralf Lindert, Katy Dakin, Jessica Redgrave, Biju Bhaskaran, Isam Salih, Debs Kelly, Susan Szabo, Dawn Tomlin, Helen Bearne, Jean Buxton, Pauline Fitzell, Georgina Ayres, Afaq Saulat, Kathleen Horan, Joanne Garfield-Smith, Harbens Bhakri, Paul Guyler, Devesh Sinha, Thayalini Loganathan, Amber Siddiqui, Anwer Siddiqui, Lucy Coward, Swapna Kunhunny, Sharon Tysoe, Rajalakshmi Orath Prabakaran, Shyam Kelavkar, Sindhu Rashmi, David Ngo(National Hospital for Neurology and Neurosurgery), Kheng Xiong Ng(National Hospital for Neurology and Neurosurgery), Nisha Menon, Sweni Shah(University of Edinburgh), Mark Barber(University of Edinburgh), Derek Esson, Fiona Brodie, Talat Anjum, Mushtaq Ahmad Wani, Manju Krishnan, Leanne Quinn, Jayne Spencer, Terry E. Jones, Helen Thompson-Jones, Lynne Dacey, Srikanth Chenna, Sharon Storton, Sarah Thomas, Teresa Beaty, Shelley Treadwell, Caroline Davies, Susan Tucker, Lynda Connor, Peter Slade(University of Edinburgh), Glyn Gainard, Girish Muddegowda, Ranjan Sanyal, Alda Remegoso, Nenette Abano, Chelsea Causley, Racquel Carpio, Stephanie Stevens, Adrian Butler, Resti Varquez, Hayley Denic, Francis Alipio, Andrew Moores, Adrian Barry, Holly Maguire, Jeanette Grocott, K. Finney, Sue Lyjko, Christine Roffe, Joanne Hiden, Phillip Ferdinand, Vera Cvoro, Khalil Ullah, Nicola Chapman, Mandy Couser, Susan Pound, Katrina McCormick, Sean Mcauley, Senthil Raghunathan, Faye Shelton, Amanda Hedstrom, Margi Godfrey, Diane Havard, Amanda Buck, Kailash Krishnan, Nicola Gilzeane, Jack Roffe, Judith Clarke, Katherine Whittamore, Saima Sheikh, Nikola Sprigg(University of Nottingham), Rekha Keshvara, Carla Jordan, Benjamin Jackson, Gwendoline Wilkes, Jason P. Appleton, Zhe Kang Law(UK Dementia Research Institute), Oliver Matias, Evangelos Vasileiadis, Cathy Mason, Anthea Parry, G Landers, Melinda Holden, Basaam Aweid, Khalid Rashed, L. Balian, Carinna Vickers, Elizabeth G. Keeling, Sarah Board, Joanna Allison(UK Dementia Research Institute), C Buckley, Barbara Williams-Yesson, Joanne Board, T Pitt-Kerby, Alfonso Tanate, Diane P. Wood, Manohar Kini, Dinesh Chadha, Deborah Walstow, Rosanna Fong, Robert Luder, Tolu Adesina, Jill Gallagher, Hayley Bridger, Elodie Murali, Maneesh Bhargava, Chloe van Someren, Frances Harrington, Abhijit Mate, Ali James, Gillian Courtauld, Christine Schofield, Katja Adie, Linda F. Lucas, Kirsty Bond, Bev Maund, Sam Ellis, Paul N. Mudd, Martin James(University of Edinburgh), Samantha Keenan, A Bowring, Julie Cageao, Hayley Kingwell, Caroline Roughan, Anthony Hemsley, Jane Sword, W. David Strain(National Hospital for Neurology and Neurosurgery), Keniesha Miller, Anita Goff, Karin Gupwell, Kevin E. Thorpe, Hedley Emsley, Shuja Punekar, Alison McLoughlin, Sulaiman Sultan, Bindu Gregory, Sonia Raj, Donna Doyle, Keith W. Muir, W. G. J. Smith, Angela Welch, Fiona Moreton, Bharath Kumar Cheripelli, Salwa El Tawil, Dheeraj Kalladka, Xuya Huang, Nicola C. Day, Sankaranarayanan Ramachandran, Caroline Crosbie, Jennifer Elliot, Tony Rudd, Katherine Marks, Ajay Bhalla, Jonathan Birns, Sagal Kullane, Nic Weir, Christopher Allen, Vanessa Pressly, Pam Crawford, Emma Battersby-Wood, Alex Blades, Shuna Egerton, Ashleigh Walters, Sue Evans, Richard Marigold, Fiona E. Smith, Gabriella Howard, Imogen Gartrell, Simon Smith, Robyn Creeden, Chloe Cox, Cherish Boxall, Jonathan Hewitt, Claire Nott, Procter Sarah, Jessica Whiteman, Steve Buckle, Rebecca Wallace, Rina Mardania, Jane Gray, Claire Triscott, Anand R. Nair, Jill Greig, Pratap Rana, Matthew K. Robinson, Mohammad Irfan Alam, David J. Werring(National Hospital for Neurology and Neurosurgery), Duncan Wilson, C Watchurst, Maria Brezitski, Luci Crook, Ifan Jones, Azra Banaras, Krishna Patel, Renuka Erande, Caroline Hogan, Isabel C. Hostettler, Amy Ashton, Shez Feerick, Nina Francia, Nnebuife Oji, Emma Elliott, Talal Al‐Mayhani, Martin Dennis(University of Edinburgh), Cathie Sudlow(University of Edinburgh), William Whiteley(University of Edinburgh), Christine Lerpiniere, Rustam Al‐Shahi Salman(University of Edinburgh), Ruth Fraser, Dipankar Dutta, Pauline Brown, Deborah Ward(UK Dementia Research Institute), Fiona Davis, Jennifer Turfrey, Chloe Hughes, Kayleigh Collins, Rehana Bakawala, Susan O’Çonnell, Jon Glass, David Broughton(National Hospital for Neurology and Neurosurgery), Dinesh Tryambake, Lynn Dixon, Kath Chapman, Andrew Young, Adrian Bergin, Andrew Sigsworth, Aravind Manoj, Glyn Fletcher, Paula Lopez, P Cox, Mark Wilkinson(University of Edinburgh), Paul Fitzsimmons, Nikhil Sharma, James Choulerton, Denise Button, Lindsey Dow, Lukuman Gbadamoshi, Joanne Avis, B. Madigan, Stephanie McCann, Louise Shaw, Deborah Howcroft, Suzanne Lucas, Andrew Stone, Gillian Cluckie, Caroline Lovelock, Brian Clarke, Neha Chopra, Natasha Clarke, Bhavini Patel, Kate Kennedy, Rebecca Williams, Adrian Blight, Joanna O’Reilly(UK Dementia Research Institute), Chukwuka Orefo, Nilofer Dayal, Rita Ghatala, Temi Adedoyin, Fran Watson, Sarah Trippier, Lillian Choy, Barry Moynihan, Usman Khan, Val Jones, Naomi Jeyaraj, Lourda Kerin, Kamy Thavanesan, Divya Tiwari, Chantel Cox, Anja Ljubez, Laura Tucker, Arshi Iqbal, Caroline Bagnall, Marketa Keltos, Josh Roberts(Addenbrooke's Hospital), Becky Jupp, Catherine Ovington, Emily Rogers, Owen David(National Hospital for Neurology and Neurosurgery), Jo Bell(UK Dementia Research Institute), Barbara Longland, Gail Hann(NHS Lothian), Martin Cooper(University of Edinburgh), Mohammad Nasar, Anoja Rajapakse, Inez Wynter, Ijaz Anwar, Helen Skinner, Tarn Nozedar, Damian McArdle, Balakrishna Kumar, Susan E. Crawford, Arunkumar Annamalai, Alex Ramshaw, Clare Holmes, Sarah Caine, Mairead Osborn, Emily Dodd, Peter Murphy(University of Edinburgh), Nicola Devitt, Pauline Baker, Amy Steele, Lucy Belle Guthrie, Samantha Clarke, Ahamad Hassan, Dean Waugh, Emelda Veraque, Linetty Makawa, Mary Kambafwile, Marc Randall, Vasileios Papavasileiou, Claire Cullen, Jenny Peters, Thant Hlaing, Tanya Ingram, Mellor Zoe, Ramesh Durairaj, Melanie Harrison, Sarah Stevenson, Daniela Shackcloth, Jordan Ewing, Victoria Sutton, Mark O. McCarron(University of Edinburgh), Jacqueline McKee(University of Edinburgh), Mandy Doherty, Ferghal McVerry, Caroline Blair, Mary Joan MacLeod, Janice Irvine, Heather Gow, Jacqueline Furnace(University of Edinburgh), Anu Joyson, Baljit Jagpal, Sarah J. Ross, Katrina Klaasen, Sandra Nelson, Rebecca Clarke, Nichola Crouch, Beverly MacLennan, Vicky Taylor, Daniel Epstein, Ifan Jones, Avani Shukla, Vinodh Krishnamurthy, Paul Nicholas, Sammie Qureshi, Adam Webber, Justin Penge, Hawraman Ramadan, Stuart Maguire, Chris Patterson, Ruth Bellfield, Brigid Hairsine, Kelvin Stewart, Michaela Hooley, Outi Quinn, Bella Richard, Sally Moseley, Claire Nott, Steve Buckle, Procter Sarah, Jessica Whiteman, Mandy Edwards, Heidi Lawson, Rebecca Wallace, Claire Triscott, Michelle Tayler, Yogish Pai(Addenbrooke's Hospital), Mahesh Dhakal, Bernard Esisi, Sofia Dima, Gemma Smith, Mark Garside(University of Edinburgh), Muhammad Naeem, Vidya Baliga, Gill Rogers, Ellen Brown, David Bruce(National Hospital for Neurology and Neurosurgery), Rachel Hayman, Susan Clayton, Ed Gamble(UK Dementia Research Institute), Rebecca Grue, Bethan Charles, Adam Hague, Sujata Blane, Caroline Lambert, Afnan Chaudhry, Thomas S. Harrison, Kari Saastamoinen, Dionne Hove, Laura Howaniec, Gemma Grimwood, Ozlem Redjep, Fiona Humphries, Lucia Argandona, Larissa Cuenoud, Esther Erumere, Sageet Amlani, Grace Auld, Afraim Salek‐Haddadi, Ursula G. Schulz, James Kennedy, Gary A. Ford, Philip Mathieson(Newcastle upon Tyne Hospital), Ian Reckless, Rachel Teal, Giulia Lenti, George Harston, Eoin O’Brien, Joanne McGee, Jennifer Mitchell, Elaine Amis, Dominic Handley, Siobhán Kelly, George Zachariah, Jobbin Francis, Sarah Crisp, Juliana Sesay, Sarah Finlay, Helen Hayhoe, Niamh Hannon, Tom Hughes, Bethan Morse, Henry de Berker, Emma Tallantyre, Ahmed Osman, Susan White(Newcastle upon Tyne Hospital), Stefan Schwarz, Benjamin Jelley, Rajendra Yadava, Khalid Azhar, Julie Reddan, Mirriam Sangombe, Samantha Stafford, K. Fotherby, Debbie Morgan, Farrukh Baig, Karla Jennings-Preece, Donna Butler, Nasar Ahmad, Angela Willberry, Angela Stevens, Baljinder Rai, Prasad Siddegowda, Peter Howard(University of Edinburgh), Afaq Saulat, Lisa Hyatt, Tracey Dobson, David Jarrett(National Hospital for Neurology and Neurosurgery), S. Ponnambath, Jane Tandy, Yasmin Harrington-Davies, Rebecca K. Butler, Claire James, Stacey L. Valentine, Anne Suttling, Peter Langhorne(University of Edinburgh), G.R. Kerr, Fiona Wright, Ruth Graham, Christine McAlpine, Mohammad Shahzad Iqbal, Louise Humphreys, Kath Pasco, Olga Balazikova, Ashraf Nasim, Cassilda Peixoto, Louise Gallagher, Shahrzad Shahmehri, Sandip Ghosh, Elizabeth S. Barrie, Danielle Gilmour, Margo Henry, Tom Webb, Linda Cowie, Hannah Rudenko, Shanni McDonald, Natasha Schumacher, Susannah B. Walker, Tracey Cosier, Anna Verrion(UK Dementia Research Institute), Eva Beranová, Audrey Thomson, Marius Venter, Arindam Kar, Sheila Mashate, Kirsten Harvey, Léjeune Gardener, Vinh Nguyen, Omid Halse, Olivia Geraghty, Beth Hazel, Peter Wilding(University of Edinburgh), Victoria Tilley, Bernard Esisi, Tim Cassidy, Beverley McClelland, Maria Bokhari, Timothy J. England, Amanda Hedstrom, Mohana Maddula, Richard Donnelly, Paul Findlay, Ashish Macaden, Ian Shread, Charlotte Barr, Azlisham Mohd Nor, Claire Brown, Nicola Persad, Charlotte Eglinton, Marie Weinling, Benjamin Hyams, Alex Shah(University of Edinburgh), John G. Baker, Anthony Byrne, Caroline McGhee, Amanda Smart, Claire Copeland, Michael D. Carpenter, Marion Walker, Richard Davey, Ann Needle(UK Dementia Research Institute), Razik Fathima, Gavin Bateman, Prabal Datta, Andrew Stanners, Linda Jackson, Julie Ball, Michelle Davis, Natalie Atkinson, Michelle Fawcett, Teresa Thompson, Helen Guy, Valerie Hogg, Carole Hays, Stephen Woodward(University of Edinburgh), Mohammad Mahfuzul Haque, Eluzai Hakim, Stuart Symonds, Mehran Maanoosi, Jane Herman, Toby Black, Skelton Miriam, Caroline S. Clarke, Alpha Anthony, Michele Tribbeck, Julie Cronin, Denise Mead, Ruth Fennelly, James McIlmoyle, Christina Dickinson, Carol Jeffs, Sajjad Anwar, Joanne Howard, Kirsty Jones, Saikat Dhar, Caroline Clay, Muhammad Siddiq, Simone Ivatts, Yolanda Baird, Sally Moore, Isobel Amey, Sophie Newton, Lisa Clayton-Evans, Indra Chadbourn, Rayessa Rayessa, Charde Naylor, Alicia Rodgers, Lisa M Wilson, Sarah Wilson, Emma Clarkson, Ruth Davies, Paula Owings, Graeme Sangster, Valerie Gott, Victoria Little, Pauline Weir, Suja Cherian, Deepa Jose, Helen Moroney, Susan Downham, Angela Dodd, Venetia Vettimootal Johnson, Laura Codd, Naomi Robinson, Ashraf Ahmed, Mo Albazzaz, Sharon A. Johnson, Carol Denniss, Mishell Cunningham, Tajammal Zahoor, Timothy Webster, Sandra Leason, Syed Haider, Kausic Chatterjee, Arumugam Nallasivan, Charlotte Perkins, Samantha Seagrave, Colin Jenkins, Fiona Price, Claire Hughes, Lily Mercer, Malik Azhar Hussain, Sarah Brown, Miriam Harvey, Jane Homan, Mohammad Faizan Khan, Robert F. Whiting, Leanne Foote, Nicholas Hunt, Helen Durman, Lucy Brotherton, Jayne Foot, Corinne Pawley, Eliza Foster, Alison Whitcher, Kneale Metcalf, Jenny Jagger, Susan A. McDonald, Kelly Waterfield, Patrick Sutton, Naval Shinh, Ajmal Anversha, Garth Ravenhill, Richard Greenwood, Janak Saada, Alison Wiltshire, Rebekah Perfitt, Sreeman Andole, Naveen Gadapa, Karen Dunne, Magdalini Krommyda, Evelyne Burssens, Sam King, Catherine Plewa, Nigel Smyth, J. Wilson, Elio Giallombardo, Charlotte Eglinton, Lucy Sykes, Pradeep Kumar, James L. Barker, Isabel Huggett, Linda Dunn, Charlotte Culmsee, Philip Thomas(Newcastle upon Tyne Hospital), Min Myint(Newcastle upon Tyne Hospital), Richard O’Brien, Helen Brew, Nikhil Majmudar, Janice O’Connell, George Bunea, Charlotte Fox, Diane Gulliver, Andrew M. Smith, Betty Mokoena, Naweed Sattar, Ramesh Krishnamurthy, E Osborne, David H. Wilson(National Hospital for Neurology and Neurosurgery), Belinda Wroath, Kevin Dynan, Mick Power, Susan Thompson, Victoria Adell, Enoch Orugun, Una Poultney, Rachel Glover, Hannah Crowther, Sarah Thornthwaite, Ivan Wiggam, Aine Wallace, Enda Kerr, Ailsa Fulton, Annemarie Hunter, Suzanne Tauro, Sarah Cuddy, David Mangion(National Hospital for Neurology and Neurosurgery), Anne Hardwick, Skarlet Markova, Tara Lawrence, Carmen Constantin, Jo Fletcher(UK Dementia Research Institute), Isobel Thomas, Kerry Pettitt, Lakshmanan Sekaran, Margaret Tate, Kiranjit Bharaj, Rohan Simon, Frances Justin, Sakthivel Sethuraman, Duke Phiri, Niaz Mohammed, Meena Chauhan, Khaled Elfandi, Uzma Khan, Samantha Stafford, Julie Reddan, D. Eveson(National Hospital for Neurology and Neurosurgery), Amit Mistri, Lisa Manning, Shagufta Khan, Champa Patel, Mohammed Moqsith, Saira Sattar, Man Y. Lam, Kashif Musarrat, Claire Stephens, Latheef Kalathil, Richard Miller, Maqsud Salehin, Nikki Gautam, Duncan Bailey, Kelly Amor, Julie Meir, Anne Nicolson, Javed Imam, Lisa J. Wood, Julie White(Newcastle upon Tyne Hospital), Mahmud Sajid, George Ghaly, Margaret Ball, Rachel Gascoyne, Harald Proeschel, Simon Sharpe, Sarah Horton, Emily Beaves, Stephanie Jones, Brigitte Yip, Murdina Bell, Linda MacLiver, Brian MacInnes, Derek Esson, Don Sims(University of Edinburgh), Jennifer Hurley, Mark Willmot(University of Edinburgh), Claire Sutton, Edward Littleton, Susan Maiden, Rachael Jones, James Cunningham, Carole Green, Michelle Bates, Raj Shekhar, Kelly Waterfield, Ellie Gilham, Iman Ahmed, R. M. Crown, Tracy Fuller, Neetish Goorah, Angela Bell, Christine Kelly, Arun Singh, Jamie Walford, Benjamin Tomlinson, Farzana Patel, Stephen Duberley(University of Edinburgh), Ingrid Kane, Chakravarthi Rajkumar, Jane Gaylard, Joanna Breeds(UK Dementia Research Institute), Nicola Gainsborough, Alexandra Pitt-Ford, Emma Barbon, Laura Latter, Philip Thompson(Newcastle upon Tyne Hospital), Simon Hervey, Shrivakumar Krishnamoorthy, Joseph A. Vassallo, Deborah Walter, Helen Cochrane, Meena Srinivasan, Robert R. Campbell, Denise Donaldson, Nichola Motherwell, Frances Hurford, Indranil Mukherjee, Antony Kenton, Sheila Nyabadza, Irene Martin(University of Edinburgh), Benjamin Hunt, Hardi Hassan, Sarah O'Toole, Bander Dallol, Janet Putterill, Ratneshwari Jha, Rachel Gallifent, Puneet Kakar, Aparna Pusalkar, Kelly Chan, Puneet Dangri, Hannah Beadle, Angela Cook, Karen Crabtree, Santhosh Subramonian, Peter Owusu‐Agyei(University of Edinburgh), Natalie Temple, Nicola Butterworth‐Cowin, Suzanne Ragab, Kerstin Knops, E. M. Jinks, Christine Dickson, Laura Gleave, Judith Dube, Jacqui Leggett, Tatiana Garcia, Sissy Ispoglou, Rachel Evans, Sandeep Ankolekar, Anne Hayes, Hlaing Ni(University of Nottingham), Bithi Rahman, Josette Milligan, Carol Graham, Josin Jose, Breffni Keegan, Mandy Doherty, Jim Kelly, Caroline Blair, Richard Dewar, James R. White(Newcastle upon Tyne Hospital), Kelly Thomas
Cited by 89Open Access
Abstract
BACKGROUND: Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy. METHODS: RESTART was a prospective, randomised, open-label, blinded-endpoint, parallel-group trial at 122 hospitals in the UK that assessed whether starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. For this prespecified subgroup analysis, consultant neuroradiologists masked to treatment allocation reviewed brain CT or MRI scans performed before randomisation to confirm participant eligibility and rate features of the intracerebral haemorrhage and surrounding brain. We followed participants for primary (recurrent symptomatic intracerebral haemorrhage) and secondary (ischaemic stroke) outcomes for up to 5 years (reported elsewhere). For this report, we analysed eligible participants with intracerebral haemorrhage according to their treatment allocation in primary subgroup analyses of cerebral microbleeds on MRI and in exploratory subgroup analyses of other features on CT or MRI. The trial is registered with the ISRCTN registry, number ISRCTN71907627. FINDINGS: >0·05). INTERPRETATION: Our findings exclude all but a very modest harmful effect of antiplatelet therapy on recurrent intracerebral haemorrhage in the presence of cerebral microbleeds. Further randomised trials are needed to replicate these findings and investigate them with greater precision. FUNDING: British Heart Foundation.
Related Papers
No related papers found
Powered by citation graph analysis