Comparative Studies Reveal Robust HbF Induction By Editing of HBG1/2 Promoters or BCL11A Erythroid-Enhancer in Human CD34+ Cells but That BCL11A Erythroid-Enhancer Editing Is Associated with Selective Reduction in Erythroid Lineage Reconstitution in a Xenotransplantation Model

Kai‐Hsin Chang(National Taiwan University), Haiyan Jiang(Inner Mongolia Agricultural University), Abhishek Dass(Editas Medicine (United States)), Gregory Gotta(Editas Medicine (United States)), Ramya Viswanathan(Editas Medicine (United States)), Eugenio Marco(Editas Medicine (United States)), Abigail Vogelaar(Editas Medicine (United States)), Eric L. Tillotson(Editas Medicine (United States)), Deepak Reyon(Harvard University), Katherine Loveluck(Editas Medicine (United States)), Emily Brennan(Editas Medicine (United States)), Georgia Giannoukos(Editas Medicine (United States)), John A. Zuris(Howard Hughes Medical Institute), Jen Da Silva(Editas Medicine (United States)), Terence Ta(Editas Medicine (United States)), Hoson Chao(Editas Medicine (United States)), Scott Haskett(Editas Medicine (United States)), Diana Tabbaa(Broad Institute), Christopher J. Wilson, Fred Harbinski(Maze (United States)), Charlie Albright(Editas Medicine (United States)), Meltem Isik(Editas Medicine (United States)), Jamaica Siwak(Editas Medicine (United States)), Edouard deDreuzy(Editas Medicine (United States)), Kiran Gogi(Editas Medicine (United States)), Aditi Chalishazar(Editas Medicine (United States)), Sandra Teixeira(Editas Medicine (United States)), Tongyao Wang(Editas Medicine (United States)), Minerva E. Sanchez(Editas Medicine (United States)), Frederick Ta(Editas Medicine (United States)), Andrew J. Sadowski(Medical University of South Carolina), Jack Heath(Unknown), Ari E. Friedland

Blood

November 29, 2018

Cited by 9

|Nature|2012|12k

|Nature|2012|8.5k

|Nature|2007|4.2k

|Genome Research|2011|3.6k

|Nature Biotechnology|2013|3.3k

Related Papers