Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ1–40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease
Mini P. Sajan(United States Department of Veterans Affairs), Robert V. Farese(University of South Florida), David M. Diamond(University of South Florida), Barbara C. Hansen(University of South Florida), Michael Leitges(Memorial University of Newfoundland), Collin R. Park(University of South Florida), C R Kahn(Joslin Diabetes Center), Ursula Braun(Medizinische Hochschule Hannover), Margaret G. Higgs(James A. Haley Veterans' Hospital)
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