Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ1–40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease

Mini P. Sajan, Robert V. Farese, Margaret G. Higgs et al.|Neurobiology of Aging|2017

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