Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

David M. Evans; Chris C. A. Spencer; Jennifer J. Pointon; Zhan Su; David Harvey; Grazyna Kochan; Udo Oppermann; Alexander Dilthey; Matti Pirinen; Millicent Stone; Louise Appleton; Loukas Moutsianas; Stephen Leslie; Tom Wordsworth; Tony Kenna; Tugce Karaderi; Gethin Thomas; Michael M. Ward; Michael H. Weisman; Claire Farrar; Linda A. Bradbury; Patrick Danoy; Robert D. Inman; Walter P. Maksymowych; Dafna Gladman; Proton Rahman; Ann W Morgan; Helena Marzo-Ortega; Paul Bowness; Karl Gaffney; J. S. Hill Gaston; Malcolm Smith; Jácome Bruges‐Armas; Ana Rita Couto; Rosa Sorrentino; Fabiana Paladini; Manuel A. R. Ferreira; Huji Xu; Yu Liu; Lei Jiang; Carlos López‐Larrea; Roberto Díaz‐Peña; Antonio López‐Vázquez; Tetyana Zayats; Gavin Band; Céline Bellenguez; Hannah Blackburn; Jenefer M. Blackwell; Elvira Bramon; Suzannah J. Bumpstead; Juan Pablo Casas; Aiden Corvin; Nicholas Craddock; Panos Deloukas; Serge Dronov; Audrey Duncanson; Sarah Edkins; Colin Freeman; Matthew Gillman; Emma Gray; Rhian Gwilliam; Naomi Hammond; Sarah Hunt; Janusz Jankowski; Alagurevathi Jayakumar; Cordelia Langford; Jennifer Liddle; Hugh S. Markus; Christopher G. Mathew; Owen T McCann; Mark I. McCarthy; Colin N A Palmer; Leena Peltonen; Robert Plomin; Simon Potter; Anna Rautanen; Rathi Ravindrarajah; Michelle Ricketts; Nilesh J. Samani; Stephen Sawcer; Amy Strange; Richard C. Trembath; Ananth C. Viswanathan; Matthew Waller; Paul A. Weston; Pamela Whittaker; Sara Widaa; Nicholas Wood; Gil McVean; John D. Reveille; B P Wordsworth; Matthew A. Brown; Peter Donnelly

doi:10.1038/ng.873

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

David M. Evans(University of Bristol), Chris C. A. Spencer(Centre for Human Genetics), Jennifer J. Pointon(National Institute for Health Research), Zhan Su(Centre for Human Genetics), David Harvey(National Institute for Health Research), Grazyna Kochan(University of Oxford), Udo Oppermann(University of Oxford), Alexander Dilthey(University of Bristol), Matti Pirinen(Medical Research Council), Millicent Stone(University of Bath), Louise Appleton(Nuffield Orthopaedic Centre), Loukas Moutsianas(University of Oxford), Stephen Leslie(University of Oxford), Tom Wordsworth(Nuffield Orthopaedic Centre), Tony Kenna(The University of Queensland), Tugce Karaderi(Nuffield Orthopaedic Centre), Gethin Thomas(The University of Queensland), Michael M. Ward(National Institutes of Health), Michael H. Weisman(Cedars-Sinai Medical Center), Claire Farrar(Nuffield Orthopaedic Centre), Linda A. Bradbury(Princess Alexandra Hospital), Patrick Danoy(Princess Alexandra Hospital), Robert D. Inman(University of Toronto), Walter P. Maksymowych(University of Alberta), Dafna Gladman(Memorial University of Newfoundland), Proton Rahman(Memorial University of Newfoundland), Ann W Morgan(NIHR Leeds Musculoskeletal Biomedical Research Unit), Helena Marzo-Ortega(National Institute for Health Research), Paul Bowness(Nuffield Orthopaedic Centre), Karl Gaffney(Norfolk and Norwich University Hospital), J. S. Hill Gaston(Addenbrooke's Hospital), Malcolm Smith(Repatriation General Hospital), Jácome Bruges‐Armas(Hospital de Santo Espirito de Angra do Heroísmo), Ana Rita Couto(Hospital de Santo Espirito de Angra do Heroísmo), Rosa Sorrentino(Sapienza University of Rome), Fabiana Paladini(Sapienza University of Rome), Manuel A. R. Ferreira(QIMR Berghofer Medical Research Institute), Huji Xu(Second Military Medical University), Yu Liu(Second Military Medical University), Lei Jiang(Second Military Medical University), Carlos López‐Larrea(Hospital Universitario Central de Asturias), Roberto Díaz‐Peña(Hospital Universitario Central de Asturias), Antonio López‐Vázquez(Hospital Universitario Central de Asturias), Tetyana Zayats(Medical Research Council), Gavin Band(University of Oxford), Céline Bellenguez(University of Oxford), Hannah Blackburn(Hospital Universitario Central de Asturias), Jenefer M. Blackwell(The University of Western Australia), Elvira Bramon(Wellcome Sanger Institute), Suzannah J. Bumpstead(Wellcome Sanger Institute), Juan Pablo Casas(London School of Hygiene & Tropical Medicine), Aiden Corvin(Trinity College Dublin), Nicholas Craddock(Cardiff University), Panos Deloukas(Wellcome Sanger Institute), Serge Dronov(Wellcome Sanger Institute), Audrey Duncanson(Wellcome Trust), Sarah Edkins(Wellcome Sanger Institute), Colin Freeman(University of Oxford), Matthew Gillman(Wellcome Sanger Institute), Emma Gray(Wellcome Sanger Institute), Rhian Gwilliam(Wellcome Sanger Institute), Naomi Hammond(Wellcome Sanger Institute), Sarah Hunt(Wellcome Sanger Institute), Janusz Jankowski, Alagurevathi Jayakumar(Wellcome Sanger Institute), Cordelia Langford(Wellcome Sanger Institute), Jennifer Liddle(Wellcome Sanger Institute), Hugh S. Markus(St George's, University of London), Christopher G. Mathew(King's College London), Owen T McCann(Wellcome Sanger Institute), Mark I. McCarthy(Oxford Centre for Diabetes, Endocrinology and Metabolism), Colin N A Palmer(Ninewells Hospital), Leena Peltonen(Wellcome Sanger Institute), Robert Plomin(King's College London), Simon Potter(Wellcome Sanger Institute), Anna Rautanen(Wellcome Sanger Institute), Rathi Ravindrarajah(Wellcome Sanger Institute), Michelle Ricketts(Wellcome Sanger Institute), Nilesh J. Samani(Glenfield Hospital), Stephen Sawcer(University of Cambridge), Amy Strange(Centre for Human Genetics), Richard C. Trembath(King's College London), Ananth C. Viswanathan(Moorfields Eye Hospital NHS Foundation Trust), Matthew Waller(Wellcome Sanger Institute), Paul A. Weston(Wellcome Sanger Institute), Pamela Whittaker(Wellcome Sanger Institute), Sara Widaa(Wellcome Sanger Institute), Nicholas Wood(University College London), Gil McVean(Centre for Human Genetics), John D. Reveille(The University of Texas Health Science Center at Houston), B P Wordsworth(National Institute for Health Research), Matthew A. Brown(Princess Alexandra Hospital), Peter Donnelly(Centre for Human Genetics)

Nature Genetics

July 10, 2011

10.1038/ng.873

Cited by 904Open Access

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