Different pattern of codon recognition by mammalian mitochondrial tRNAs.
B. G. Barrell(Medical Research Council), Stephen K. Anderson, Alan T. Bankier(Medical Research Council), M H de Bruijn(Kent State University), E. Chen(Kent State University), Alan Coulson(Kent State University), Jacques Drouin(Kent State University), Ian C. Eperon(Kent State University), Donald P. Nierlich(Kent State University), B.A. Roe(Kent State University), Frederick Sanger(Kent State University), Peter Schreier(Kent State University), Andrew J. H. Smith(Kent State University), Rodger Staden(Kent State University), Ian G. Young(Kent State University)
Cited by 274Open Access
Abstract
Analysis of an almost complete mammalian mitochondrial DNA sequence has identified 23 possible tRNA genes and we speculate here that these are sufficient to translate all the codons of the mitochondrial genetic code. This number is much smaller than the minimum of 31 required by the wobble hypothesis. For each of the eight genetic code boxes with four codons for one amino acid we find a single specific tRNA gene with T in the first (wobble) position of the anticodon. We suggest that these tRNAs with U in the wobble position can recognize all four codons in these genetic code boxes either by a "two out of three" base interaction or by U.N wobble.
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