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B. G. Barrell

Wellcome Sanger Institute

Publishes on RNA and protein synthesis mechanisms, Genomics and Phylogenetic Studies, Viral-associated cancers and disorders. 60 papers and 49.6k citations.

60Publications
49.6kTotal Citations

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Top publicationsby citations

Life with 6000 Genes
A. Goffeau, B. G. Barrell, Howard Bussey et al.|Science|1996
Cited by 4.3k

The genome of the yeast Saccharomyces cerevisiae has been completely sequenced through a worldwide collaboration. The sequence of 12,068 kilobases defines 5885 potential protein-encoding genes, approximately 140 genes specifying ribosomal RNA, 40 genes for small nuclear RNA molecules, and 275 transfer RNA genes. In addition, the complete sequence provides information about the higher order organization of yeast's 16 chromosomes and allows some insight into their evolutionary history. The genome shows a considerable amount of apparent genetic redundancy, and one of the major problems to be tackled during the next stage of the yeast genome project is to elucidate the biological functions of all of these genes.