Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor
Antonia F. Stepan(Pfizer (United States)), Christopher J. O’Donnell(Pfizer (United States)), Annie Won(Pfizer (United States)), Jason K. Dutra(Pfizer (United States)), E. Sibley(Pfizer (United States)), David Riddell(Eli Lilly (United States)), Theresa J. O’Sullivan(Pfizer (United States)), Peter H. Dorff(Pfizer (United States)), Bethany L. Kormos(Pfizer (United States)), W. Scott McDonald(Pfizer (United States)), Charles E. Nolan(Pfizer (United States)), Leslie R. Pustilnik(Pfizer (United States)), Chakrapani Subramanyam(Pfizer (United States)), Blossom Sneed(Pfizer (United States)), Gregory W. Kauffman(Pfizer (United States)), Kenneth J. DiRico(Pfizer (United States)), S.H. Capetta(Pfizer (United States)), Kevin Atchison(Merck & Co., Inc., Rahway, NJ, USA (United States)), Ashley Robshaw(Pfizer (United States)), Christine Oborski(ProterixBio (United States)), Liming Zhang(North China University of Technology), Michael E. Green(Pfizer (United States)), Stacey L. Becker(Pfizer (United States)), Ivan Efremov(Pfizer (United States)), Kapil Karki(Pfizer (United States)), Yasong Lu(Pfizer (United States)), A.J. Hallgren(Pfizer (United States))
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