Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase InhibitorAntonia F. Stepan, Christopher J. O’Donnell, Chakrapani Subramanyam et al.|Journal of Medicinal Chemistry|2012Cited by 460
Metabolism-Directed Design of Oxetane-Containing Arylsulfonamide Derivatives as γ-Secretase InhibitorsAntonia F. Stepan, R. Scott Obach, Kapil Karki et al.|Journal of Medicinal Chemistry|2011Cited by 106
Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug–Drug Interactions with a Novel Series of Centrally Efficacious BACE1 InhibitorsMichael A. Brodney, Brian T. O’Neill, David Riddell et al.|Journal of Medicinal Chemistry|2015Cited by 78
Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitorsAndrea M. Zuhl, Douglas S. Johnson, Charles E. Nolan et al.|Nature Communications|2016Cited by 77
Discovery of a Series of Efficient, Centrally Efficacious BACE1 Inhibitors through Structure-Based Drug DesignChristopher R. Butler, Brian T. O’Neill, Michael A. Brodney et al.|Journal of Medicinal Chemistry|2015Cited by 46