Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase InhibitorAntonia F. Stepan, Christopher J. O’Donnell, Chakrapani Subramanyam et al.|Journal of Medicinal Chemistry|2012Cited by 460
Metabolism-Directed Design of Oxetane-Containing Arylsulfonamide Derivatives as γ-Secretase InhibitorsAntonia F. Stepan, R. Scott Obach, Chakrapani Subramanyam et al.|Journal of Medicinal Chemistry|2011Cited by 106
Cerebrospinal Fluid Amyloid-β (Aβ) as an Effect Biomarker for Brain Aβ Lowering Verified by Quantitative Preclinical AnalysesYasong Lu, Martin Pettersson, David Riddell et al.|Journal of Pharmacology and Experimental Therapeutics|2012Cited by 36
Quantitative Pharmacokinetic/Pharmacodynamic Analyses Suggest That the 129/SVE Mouse Is a Suitable Preclinical Pharmacology Model for Identifying Small-Molecule γ-Secretase InhibitorsYasong Lu, David Riddell, Liming Zhang et al.|Journal of Pharmacology and Experimental Therapeutics|2011Cited by 24
Cerebrospinal Fluid β-Amyloid Turnover in the Mouse, Dog, Monkey and Human Evaluated by Systematic Quantitative AnalysesYasong Lu, David Riddell, Hugh A. Barton et al.|Neurodegenerative Diseases|2012Cited by 21