Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.
Marguerite A. Butler(National Center for Toxicological Research), Fred F. Kadlubar(Courtauld Institute of Art), M. Iwasaki(National Center for Toxicological Research), F. Peter Guengerich(Vanderbilt University)
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