Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targetsLynn Bedford(University of Nottingham), James E. Brownell(AstraZeneca (United States))Nature Reviews Drug DiscoveryDecember 10, 201010.1038/nrd3321Cited by 554SaveCiteExport RISWatch citationsRelated PapersAn inhibitor of NEDD8-activating enzyme as a new approach to treat cancer|Nature|2009|2kSubstrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ|Molecular Cell|2010|461Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor|Nature Chemical Biology|2017|228Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway|Cell Death and Disease|2017|55