Leaderboards/Wnt/β-catenin signaling in development and cancer

Wnt/β-catenin signaling in development and cancer

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

1
Shenghong Ma
University of California San Diego
2
Lena P. Basta
Duke University
3
Yuan‐Tong Liu
Wuhan University
4
Nathaniel R. Kastan
Rockefeller University
5
Catalina Rozalén
Hospital Del Mar
6
Choong-Jae Lee
Gwangju Institute of Science and Technology
7
Luanbiao Sun
Jilin University
8
Neha Pincha
Institute for Stem Cell Biology and Regenerative Medicine
9
Yuta Adachi
Kyoto University
10
Xueying Wan
Ministry of Education

Papers

1
Dysregulated Wnt/β-catenin signaling confers resistance to cuproptosis in cancer cells
Cell Death and Differentiation|2024
74 cit.
2
Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development
Nature Cell Biology|2024
50 cit.
3
Small-Molecule Activation of Yap for Inner-Ear Regeneration – and Beyond
Digital Commons - RU (Rockefeller University)|2025
0 cit.
4
Publication in Cancer Communications (2026) [W7119524803]
Cancer Communications|2026
0 cit.

Emerging Leaders

Drafting the new consensus

Researchers

1
Jinxiang Yuan
Jining Medical University
2
Lukas E. Dow
Cornell University
3
Claudio Cantù
Linköping University
4
Milad Ashrafizadeh
Shandong Tumor Hospital
5
Pradeep S. Tanwar
University of Newcastle Australia
6
Hamed Mirzaei
Kashan University of Medical Sciences
7
Rui Zhang
University of Miami
8
Aryeh Warmflash
Simulation Technologies (United States)
9
Huadong Pei
Georgetown University
10
Naguissa Bostaille
Université Libre de Bruxelles

Papers

1
Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets
Signal Transduction and Targeted Therapy|2024
599 cit.
2
Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants
Nature Biotechnology|2022
129 cit.
3
A bioinformatics analysis, pre-clinical and clinical conception of autophagy in pancreatic cancer: Complexity and simplicity in crosstalk
Pharmacological Research|2023
84 cit.
4
Doxorubicin-loaded graphene oxide nanocomposites in cancer medicine: stimuli-responsive carriers, co-delivery and suppressing resistance
Expert Opinion on Drug Delivery|2022
80 cit.
5
Nanotechnological Approaches in Prostate Cancer Therapy: Integration of engineering and biology
Nano Today|2022
76 cit.
6
Bovine and human endometrium-derived hydrogels support organoid culture from healthy and cancerous tissues
Proceedings of the National Academy of Sciences|2022
76 cit.
7
Nodal is a short-range morphogen with activity that spreads through a relay mechanism in human gastruloids
Nature Communications|2022
63 cit.
8
The CUT&RUN suspect list of problematic regions of the genome
Genome biology|2023
62 cit.
9
Virus, Exosome, and MicroRNA: New Insights into Autophagy
Advances in experimental medicine and biology|2022
43 cit.
10
Combinatorial interpretation of BMP and WNT controls the decision between primitive streak and extraembryonic fates
Cell Systems|2024
39 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

1
Hans Clevers
Hubrecht Institute for Developmental Biology and Stem Cell Research
2
Masatoshi Takeichi
RIKEN Center for Biosystems Dynamics Research
3
Elaine Fuchs
Howard Hughes Medical Institute
4
Walter Birchmeier
Max Delbrück Center
5
Roel Nusse
Howard Hughes Medical Institute
6
Kun‐Liang Guan
Westlake University
7
Xi He
Boston Children's Hospital
8
Christof Niehrs
Heidelberg University
9
Stefano Piccolo
University of Padua
10
Elisabetta Dejana
Uppsala University

Papers

1
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
Nature|2009
7.2k cit.
2
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Nature Cell Biology|2011
7k cit.
3
Role of YAP/TAZ in mechanotransduction
Nature|2011
5.9k cit.
4
Identification of stem cells in small intestine and colon by marker gene Lgr5
Nature|2007
5.7k cit.
5
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
Cell|2003
3.9k cit.
6
Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium
Gastroenterology|2011
3.8k cit.
7
Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC <sup>−/−</sup> Colon Carcinoma
Science|1997
3.3k cit.
8
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
Genes & Development|2007
3.2k cit.
9
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
Nature Cell Biology|2002
3.1k cit.
10
Functional interaction of β-catenin with the transcription factor LEF-1
Nature|1996
2.9k cit.

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