Leaderboards/Quinazolinone synthesis and applications

Quinazolinone synthesis and applications

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Papers

PDE4B inhibition by nerandomilast: Effects on lung fibrosis and transcriptome in fibrotic rats and on biomarkers in human lung epithelial cells

British Journal of Pharmacology|2024

36 cit.

Insights into the Cellular and Molecular Mechanisms behind the Antifibrotic Effects of Nerandomilast

American Journal of Respiratory Cell and Molecular Biology|2025

30 cit.

Carbon-Atom Scavengers Enable Divergent, Selective Carbon Deletion of Azaarenes

Journal of the American Chemical Society|2025

21 cit.

Selenomethionine modulates the JAK2 / STAT3 / A20 pathway through oxidative stress to alleviate LPS-induced pyroptosis and inflammation in chicken hearts

Biochimica et Biophysica Acta (BBA) - General Subjects|2024

19 cit.

SiO2 NP promotes allergic gastritis induced by degranulation of mouse MC9 cell through AQP4-mediated impairment of SIRT3-TFAM deacetylation and mitochondrial autophagy

Journal of Hazardous Materials|2025

7 cit.

A Size-Determined Growth Rule Enables Well-Preserved Silver–Gold Core–Shell Nanocubes for Reliable Surface-Enhanced Raman Scattering Bioanalysis

ACS Nano|2025

4 cit.

Staying in the Flow: Preferential PDE4B Inhibitor Nerandomilast (BI 1015550) Improves Features of Vascular Dysfunction in Lung Fibrosis In Vitro and In Vivo

Unknown Journal|2024

3 cit.

Publication in Lara D. Veeken (2025) [1 citation, W4409900029]

Lara D. Veeken|2025

1 cit.

Emerging Leaders

Drafting the new consensus

Papers

Design, Synthesis, Docking, DFT, MD Simulation Studies of a New Nicotinamide-Based Derivative: In Vitro Anticancer and VEGFR-2 Inhibitory Effects

Molecules|2022

120 cit.

New quinoline and isatin derivatives as apoptotic VEGFR-2 inhibitors: design, synthesis, anti-proliferative activity, docking, ADMET, toxicity, and MD simulation studies

Journal of Enzyme Inhibition and Medicinal Chemistry|2022

67 cit.

Well-Defined Phosphine-Free Manganese(II)-Complex-Catalyzed Synthesis of Quinolines, Pyrroles, and Pyridines

The Journal of Organic Chemistry|2022

63 cit.

Novel chalcone derivatives of ursolic acid as acetylcholinesterase inhibitors: Synthesis, characterization, biological activity, ADME prediction, molecular docking and molecular dynamics studies

Journal of Molecular Structure|2023

61 cit.

Optimization and SAR investigation of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as EGFR and BRAFV600E dual inhibitors with potent antiproliferative and antioxidant activities

Bioorganic Chemistry|2022

59 cit.

Synthesis, biological evaluation, and molecular docking of new series of antitumor and apoptosis inducers designed as VEGFR-2 inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry|2022

57 cit.

Multi-Step In Silico Discovery of Natural Drugs against COVID-19 Targeting Main Protease

International Journal of Molecular Sciences|2022

57 cit.

New 1,3,4‐oxadiazoles linked with the 1,2,3‐triazole moiety as antiproliferative agents targeting the EGFR tyrosine kinase

Archiv der Pharmazie|2022

55 cit.

Synthesis and Evaluation of Quinazolin‐4(3 <i>H</i> )‐one Derivatives as Multitarget Metabolic Enzyme Inhibitors: A Biochemistry‐Oriented Drug Design

ChemistrySelect|2023

55 cit.

Well-Defined NNS-Mn Complex Catalyzed Selective Synthesis of C-3 Alkylated Indoles and Bisindolylmethanes Using Alcohols

The Journal of Organic Chemistry|2022

53 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

John Kuriyan

Vanderbilt University

Laurent Meijer

ManRos Therapeutics (France)

Patrick P. Zarrinkar

Unknown

David J. Lockhart

Io Therapeutics (United States)

Thierry Besson

Centre National de la Recherche Scientifique

Nathanael S. Gray

Stanford University

Xiao‐Feng Wu

Dalian Institute of Chemical Physics

William A. Denny

Maurice Wilkins Centre

Flavio Solca

Boehringer Ingelheim (Austria)

Kah Keng Wong

Universiti Sains Malaysia

Papers

Expression monitoring by hybridization to high-density oligonucleotide arrays

Nature Biotechnology|1996

2.9k cit.

A quantitative analysis of kinase inhibitor selectivity

Nature Biotechnology|2008

2.4k cit.

Comprehensive analysis of kinase inhibitor selectivity

Nature Biotechnology|2011

2.4k cit.

A small molecule–kinase interaction map for clinical kinase inhibitors

Nature Biotechnology|2005

1.9k cit.

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

Journal of Biological Chemistry|2009

1.8k cit.

Structural Mechanism for STI-571 Inhibition of Abelson Tyrosine Kinase

Science|2000

1.8k cit.

An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor

Cell|2006

1.6k cit.

BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models

Oncogene|2008

1.4k cit.

Biochemical and Cellular Effects of Roscovitine, a Potent and Selective Inhibitor of the Cyclin‐Dependent Kinases cdc2, cdk2 and cdk5

European Journal of Biochemistry|1997

1.4k cit.

Crystal structure of the Src family tyrosine kinase Hck

Nature|1997

1.2k cit.

Reagents for Quinazolinone synthesis and applications

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