Leaderboards/Protein Kinase Regulation and GTPase Signaling

Protein Kinase Regulation and GTPase Signaling

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

1
Julien Dilly
Massachusetts Institute of Technology
2
Urszula N. Wasko
Revolution Medicines (United States)
3
Chenchun Weng
University of Science and Technology of China
4
Joshua Cook
Colorado State University
5
Zhongwei Mao
King Center
6
Jonathan E. Tullis
University of Colorado Anschutz Medical Campus
7
Xiangdong Lv
National University of Defense Technology
8
Fredrik Sadler
University of Minnesota
9
Juliana A. Martinez Fiesco
Frederick National Laboratory for Cancer Research
10
Emre Tkacik
Dana-Farber Cancer Institute

Papers

1
Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer
Cancer Discovery|2024
234 cit.
2
Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer
Nature|2024
175 cit.
3
14-3-3 binding maintains the Parkinson’s associated kinase LRRK2 in an inactive state
Nature Communications|2025
11 cit.
4
Publication in Journal of Biological Chemistry (2025) [7 citations, W4414938591]
Journal of Biological Chemistry|2025
7 cit.
5
Publication in Scientific Reports (2024) [4 citations, W4400450826]
Scientific Reports|2024
4 cit.
6
A Deep Learning Approach for Identifying Intentional AIS Signal Tampering in Maritime Trajectories
Journal of Marine Science and Engineering|2025
3 cit.
7
Sequential design of single-cell experiments to identify discrete stochastic models for gene expression
Unknown Journal|2024
2 cit.
8
Abstract B101: Tumor-selective inhibition of active RAS in pancreatic ductal adenocarcinoma
Cancer Research|2024
1 cit.
9
Abstract A093: Deciphering acquired resistance to KRASG12D inhibition in a mouse model of pancreatic ductal adenocarcinoma
Cancer Research|2024
0 cit.
10
Publication in Cancer Research (2024) [W4393073481]
Cancer Research|2024
0 cit.

Emerging Leaders

Drafting the new consensus

Researchers

1
Atul R. Chopra
Discovery Laboratories (United States)
2
Ryan T. Strachan
University of North Carolina at Chapel Hill
3
John E. Burke
University of Victoria
4
Yasushi Kondo
Paul Scherrer Institute
5
Qianhui Qu
Fudan University
6
Tsan-Wen Lu
Bay Institute
7
David Wildes
Revolution Medicines (United States)
8
Zexian Fu
Hebei University of Engineering
9
Jiaojiao Zhang
Wuhan Institute of Physics and Mathematics
10
Andrew J. Aguirre
Broad Institute

Papers

1
Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer
Cancer Discovery|2024
234 cit.
2
Insights into distinct signaling profiles of the µOR activated by diverse agonists
Nature Chemical Biology|2022
125 cit.
3
Structure–function analysis of the SHOC2–MRAS–PP1C holophosphatase complex
Nature|2022
85 cit.
4
Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus
Nature Communications|2023
80 cit.
5
Protein tyrosine phosphatase receptor δ serves as the orexigenic asprosin receptor
Cell Metabolism|2022
53 cit.
6
Oncogenic Drivers and Therapeutic Vulnerabilities in KRAS Wild-Type Pancreatic Cancer
Clinical Cancer Research|2023
46 cit.
7
Transport and inhibition mechanism for VMAT2-mediated synaptic vesicle loading of monoamines
Cell Research|2024
42 cit.
8
Clinical and Genomic Features of Classical and Basal Transcriptional Subtypes in Pancreatic Cancer
Clinical Cancer Research|2024
32 cit.
9
A neomorphic protein interface catalyzes covalent inhibition of RAS <sup>G12D</sup> aspartic acid in tumors
Science|2025
31 cit.
10
Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs
Cell Reports|2023
28 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

1
Robert J. Lefkowitz
Howard Hughes Medical Institute
2
David M. Sabatini
Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry
3
Michael E. Greenberg
Harvard University
4
Joseph Schlessinger
Yale University
5
Philip Cohen
MRC Protein Phosphorylation and Ubiquitylation Unit
6
Roger J. Davis
University of Massachusetts Chan Medical School
7
Kozo Kaibuchi
Fujita Health University
8
Lewis C. Cantley
Harvard University
9
Channing J. Der
University of North Carolina at Chapel Hill
10
Shuh Narumiya
Kyoto University

Papers

1
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
Cell|1999
6.6k cit.
2
Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex
Science|2005
6.2k cit.
3
Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery
Cell|1997
5.7k cit.
4
CellProfiler: image analysis software for identifying and quantifying cell phenotypes
Genome biology|2006
5.5k cit.
5
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
Science|1995
5.3k cit.
6
Specificity and mechanism of action of some commonly used protein kinase inhibitors
Biochemical Journal|2000
4.1k cit.
7
Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase
Science|2004
3.2k cit.
8
JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
Cell|1994
3.2k cit.
9
Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene
Nature|1984
3.2k cit.
10
Specificity and mechanism of action of some commonly used protein kinase inhibitors
Biochemical Journal|2000
3.1k cit.

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