Leaderboards/PI3K/AKT/mTOR signaling in cancer

PI3K/AKT/mTOR signaling in cancer

Last updated July 15, 2026

Rising Stars

Fresh ink, massive impact

Researchers

1
Diana-Theodora Morgos
Carol Davila University of Medicine and Pharmacy
2
Grace Q. Gong
London Cancer
3
Alessandro Montemurro
Technical University of Denmark
4
Margaret E. Torrence
Harvard University
5
Hanxiao Zhang
Centre National de la Recherche Scientifique
6
Sulaiman K. Marafie
Dasman Diabetes Institute
7
Johann S. Bergholz
Broad Institute
8
Bridget S. Gosis
University of Pennsylvania
9
Lamis Yehia
Cleveland Clinic
10
Nikos Koundouros
Cornell University

Papers

1
Targeting PI3K/AKT/mTOR and MAPK Signaling Pathways in Gastric Cancer
International Journal of Molecular Sciences|2024
157 cit.
2
mTOR: Its Critical Role in Metabolic Diseases, Cancer, and the Aging Process
International Journal of Molecular Sciences|2024
85 cit.
3
Publication in Science (2025) [34 citations, W4408388856]
Science|2025
34 cit.
4
Precision Targeting of Mutant PI3Kα
Cancer Discovery|2024
6 cit.
5
ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding
Biochemical Journal|2024
3 cit.
6
Targeting mTOR Kinase with Natural Compounds: Potent ATP-Competitive Inhibition Through Enhanced Binding Mechanisms
Pharmaceuticals|2024
2 cit.
7
The Micro-Structure of the Celiac Ganglia—A Two-Photon Microscopy Study on Parkinson’s Disease
Diagnostics|2025
2 cit.
8
Spotting the clues: cluster of differentiation—a perspective of immune response intertwined with dysautonomia in colon cancer – a prospective cohort study
Journal of Medicine and Life|2025
1 cit.
9
The celiac ganglia and trunk: an assessment of anatomical variants and their clinical relevance
Journal of Medicine and Life|2025
0 cit.
10
Publication in Diabetes Research and Clinical Practice (2025) [W4417316001]
Diabetes Research and Clinical Practice|2025
0 cit.

Emerging Leaders

Drafting the new consensus

Researchers

1
Géraldine Farjot
Air Liquide (France)
2
Stephanie Heinzlmeir
German Cancer Research Center
3
John E. Burke
University of Victoria
4
Jose M. Orozco
Harvard University
5
Ivan Yudushkin
University of Vienna
6
Szu Shen Wong
Keele University
7
Jenna L. Jewell
Southwestern Medical Center
8
Jonathan D. Lee
Harvard University Press
9
Shu‐Yu Lin
Protéomique, Réponse Inflammatoire et Spectrométrie de Masse
10
Xiujun Chang
Capital Medical University

Papers

1
The Concise Guide to PHARMACOLOGY 2023/24: Enzymes
British Journal of Pharmacology|2023
439 cit.
2
Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus
Nature Communications|2023
80 cit.
3
Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs
Cell Reports|2023
28 cit.
4
SNAT7 regulates mTORC1 via macropinocytosis
Proceedings of the National Academy of Sciences|2022
26 cit.
5
ATP-competitive and allosteric inhibitors induce differential conformational changes at the autoinhibitory interface of Akt1
Structure|2023
24 cit.
6
Molecular basis for plasma membrane recruitment of PI4KA by EFR3
Science Advances|2024
15 cit.
7
Inhibition of phosphodiesterase 4D suppresses mTORC1 signaling and pancreatic cancer growth
JCI Insight|2023
12 cit.
8
Molecular insight on the role of the phosphoinositide PIP3 in regulating the protein kinases Akt, PDK1, and BTK
Biochemical Society Transactions|2025
12 cit.
9
Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53
Cell Reports|2023
11 cit.
10
Molecular basis for the recruitment of the Rab effector protein WDR44 by the GTPase Rab11
Journal of Biological Chemistry|2022
10 cit.

Current Senior Leaders

Wrote the book, still writing it

Researchers

1
David M. Sabatini
Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry
2
Pier Paolo Pandolfi
University of Turin
3
Charis Eng
Cleveland Clinic
4
Kun‐Liang Guan
Westlake University
5
Michael N. Hall
University of Basel
6
Lewis C. Cantley
Harvard University
7
John Blenis
Cornell University
8
Ramon Parsons
Icahn School of Medicine at Mount Sinai
9
Nahum Sonenberg
McGill University
10
P. Andrew Futreal
Wellcome Sanger Institute

Papers

1
Mutations of the BRAF gene in human cancer
Nature|2002
10.7k cit.
2
A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
Cell|2011
7.7k cit.
3
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Nature Cell Biology|2011
7k cit.
4
Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex
Science|2005
6.2k cit.
5
CellProfiler: image analysis software for identifying and quantifying cell phenotypes
Genome biology|2006
5.5k cit.
6
<i>PTEN</i> , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer
Science|1997
4.8k cit.
7
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
Cell|2003
3.9k cit.
8
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
Genes & Development|2007
3.2k cit.
9
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
Nature Cell Biology|2002
3.1k cit.
10
mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery
Cell|2002
3k cit.

Reagents for PI3K/AKT/mTOR signaling in cancer

Citation-validated products used in this field

🔥 Trending

Gaining adoption fast

⭐ Top Rated

Best all-around

Cell Signaling TechnologyEvidence 69

PTEN (138G6) Rabbit Monoclonal Antibody

Cited in 33 papers
#9559$152,855
View Evidence →
Cell Signaling TechnologyEvidence 67

Phospho-AMPK alpha (Thr172) (40H9) Rabbit Monoclonal Antibody (Biotinylated)

Cited in 25 papers
#5256$587
View Evidence →
Cell Signaling Technology

Phospho-WIPI2 (Ser413) Antibody

Cited in 25 papers
#13571$362
View Evidence →

🌟 All-Time

Most validated

Cell Signaling Technology

TFIIE-alpha Antibody

Cited in 54 papers
#13375$317
View Evidence →
Cell Signaling Technology

PSMG1/PAC1 Antibody

Cited in 47 papers
#13378$317
View Evidence →
Cell Signaling TechnologyEvidence 64

Cas9 (S. aureus) (6H4) Mouse Monoclonal Antibody (Alexa Fluor® 488 Conjugate)

Cited in 43 papers
#10314$465
View Evidence →