W. H. PRESCOTT

The leukocyte-transforming agent was found in the pharyngeal secretions of 75% of 36 patients with infectious mononucleosis (1M), 18% of 27 persons with acute illness other than 1M, and 27% of 11 healthy persons. Five of 12 patients with 1M were still excreting the agent three to 12 months after onset of illness. When the pharyngeal secretion was tested at intervals throughout the course of illness instead of only once at the time of admission, all five patients with 1M whose first throat washing was negative were shown to excrete the transforming agent at sometime in the course of illness.

Global Positioning System (GPS) technology with high sampling rates (∼10 sps) allows scientifically justified and economically feasible dynamic measurements of relative displacements of long‐period structures—otherwise difficult to measure directly by other means, such as the most commonly used accelerometers that require post‐processing including double integration. We describe an experiment whereby the displacement responses of a simulated tall building are measured clearly and accurately in real‐time. Such measurements can be used to assess average drift ratios and changes in dynamic characteristics and therefore can be used by engineers and building owners or managers to assess the building performance during extreme motions caused by earthquakes and strong winds, by establishing threshold displacements or drift ratios and identifying changing dynamic characteristics. Such information can then be used to secure public safety and/or take steps to improve the performance of the building.

The central enigma of the mid‐continent region in the United States known as the New Madrid seismic zone (NMSZ; Figure 1) involves the mechanisms that give rise to recurrent great earthquakes far from plate boundaries. Given the lack of significant topographic relief that is the hallmark of tectonic activity in most actively deforming regions, most of us feel a need to “pinch ourselves to see if we're dreaming” when confronted with evidence that, at some probability levels, the earthquake hazard throughout the NMSZ is comparable to that estimated for the San Francisco Bay region. Although assessing the hazard in the NMSZ is in many ways more challenging than in the western United States, and the uncertainties are much greater, careful scientific study has led to a consensus on the issues most critical to seismic hazard assessment.

an aortic régurgitation, were made out, and there were also moist râles above the right clavicle.Case X. William M., aged forty, complained that for one week he had experienced cough and pain in the chest.No other symptoms could be elicited.Examination disclosed moist rales in both bases behind, also a double aortic murmur and a systolic murmur at the apex transmitted into the axilla.Case XL F. S., aged fifty-six, paper-hanger, has had a cougli all winter, with little expectoration, and he also suffers from " sour stomach."The heart is irregular in action and the aortic valve is incompe- tent.Case XII.Daniel S., aged seventy-two, complains of being "sore all over" and "choked up in the chest."He coughs all night, with a mucous expectora- tion.Bread and tea are the chief diet.The pulse is irregular, feeble and intermittent.There is a faint systolic murmur at the apex, transmitted towards the axilla.Pulmonary oedema exists at the bases of both lungs.Of these twelve patients, five had disease of both the aortic and mitral valves, four had mitral régurgitation, one had mitral stenosis, one had aortic régurgitation, and one had both stenosis and incompetence of the aortic valves.Of the C84 cases reported by Sir Andrew Clark, 41 per cent, had mitral régurgitation, 24-]per cent, had aortic stenosis, 14 per cent, had affections of both valves, 9 per cent, had mitral stenosis, 4£ per cent, aortic régurgitation, 3£ per cent, aortic obstruc- tion and régurgitation, and 2£ per cent, mitral ob- struction and régurgitation.According to his experience, therefore, we might infer that mitral régurgitation is the least unfavorable valvular disease, and next to it aortic stenosis ; but different authorities differ widely about this question.Fagge regards aortic stenosis as of the least relative importance, followed by mitral stenosis, next to which but separated by a long interval-come mitral régurgitation and aortic régurgitation.Strümpell believes that aortic régurgitation generally gives the best prognosis, that mitral insufficiency is rather worse, and that worst of all are mitral stenosis and aortic stenosis.If we search for an explanation of these apparent contradictions, we shall find it in the all-iraportant fact that every case of heart-disease must be judged inde- pendently.The crucial test for the heart is its ability to carry on the circulation.Now it is easy to see