Cited by 108Open Access
Shandong University of Science and Technology
Publishes on Plant Stress Responses and Tolerance, Carbon Nanotubes in Composites, Plant-Microbe Interactions and Immunity. 6 papers and 202 citations.
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High-dose ionizing irradiations can cause acute tissue and organ damage, especially severe cutaneous lesions. These cutaneous injuries often result in further complications and incur high mortality. Therefore, it is critical to develop effective therapeutic approaches for acute high-dose ionizing irradiation injury. Intracellular reactive oxygen species (ROS) have been implicated in mediating irradiation-induced cell damage. In the present study, we investigated the protective effect of engineered fullerene nanoparticles on γ irradiation-induced intracellular ROS levels in human epidermal keratinocytes (HEK). Cells were exposed to water-soluble fullerene derivatives at concentrations of 25, 50, and 100 µg/ml. Exposure of HEK cells to high-dose gamma (γ) irradiation (10 and 17 Gy) resulted in a significant increase in cellular ROS levels. The observed γ-irradiation induced ROS response was notably attenuated by modified-fullerenes, CD-C60, tris-C60 and hexa-C60. Our results point to the potential use of fullerene derivatives as novel therapeutic agents for protection against high-dose irradiation generated ROS-induced cellular damage.
We have done an acute toxicological experiment on the rat kidney by administration of SVATE-3 in clinical dose (high and low dose, respectively) for 3 weeks. By using morphological methods, light and electron microscopy, enzyme morphological methods, light and electron microscopy, enzyme histocytochemistry in light and electron microscope and biochemistry, we have observed the histological structure and ultrastucture of rat kidney as well as the activity and distribution of the index enzymes for the kidney cell membrane such as Mg-adenosine triphosphatase, 5′-nucleotidase, alkaline phosphatase and glucose-6-phosphatase for kidney cell organelle: endoplasmic reticulum. Futhermore, the biochemical quantitation has been given. The results show that there is no toxic damage to the histological structure and enzyme activity and distribution of rat kidney by administration of SVATE-3 in the low dose. But in high dose, the filter membrane of the kidney was damaged and the activity of Mg-ATPase were decreased. This suggests that we should pay more attention to SVATE-3′s toxicological threshold value when using it and get safe treatment.