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Bo tjan Likar

University of Ljubljana

Publishes on Medical Image Segmentation Techniques, Advanced MRI Techniques and Applications, Radiomics and Machine Learning in Medical Imaging. 1 papers and 61 citations.

1Publications
61Total Citations

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Top publicationsby citations

MRI intensity inhomogeneity correction by combining intensity and spatial information
Uro Vovk, Franjo Pernu, Bo tjan Likar|Physics in Medicine and Biology|2004
Cited by 61

We propose a novel fully automated method for retrospective correction of intensity inhomogeneity, which is an undesired phenomenon in many automatic image analysis tasks, especially if quantitative analysis is the final goal. Besides most commonly used intensity features, additional spatial image features are incorporated to improve inhomogeneity correction and to make it more dynamic, so that local intensity variations can be corrected more efficiently. The proposed method is a four-step iterative procedure in which a non-parametric inhomogeneity correction is conducted. First, the probability distribution of image intensities and corresponding second derivatives is obtained. Second, intensity correction forces, condensing the probability distribution along the intensity feature, are computed for each voxel. Third, the inhomogeneity correction field is estimated by regularization of all voxel forces, and fourth, the corresponding partial inhomogeneity correction is performed. The degree of inhomogeneity correction dynamics is determined by the size of regularization kernel. The method was qualitatively and quantitatively evaluated on simulated and real MR brain images. The obtained results show that the proposed method does not corrupt inhomogeneity-free images and successfully corrects intensity inhomogeneity artefacts even if these are more dynamic.