Wenjie Wang

The nano-complexes facilitated baicalin, antigen, and immunostimulant delivery to M2-like TAMs, which polarized and reversed the M2-like TAM phenotype and remodeled the tumor microenvironment to allow killing of tumor cells.

As an important part of All-Time star sensor design, the generation of the short-wave infrared (SWIR) guide star catalog is crucial to the system performance. The generation process needs estimation of the instrument magnitude and the guide star selection. Different from the commonly used star sensors, since the SWIR band is far away from the visual band and the detectable magnitude limit of the All-Time star sensor is dynamically changing as the observation conditions vary, the current methods of estimating the instrument magnitude cannot be directly applied and the catalog obtained through the current reduction methods that mainly aimed at improving the distribution uniformity cannot ensure enough stars measured in the field of view under strong sky background radiation. To solve the problems, we propose a method for guide star catalog generation for the All-Time star sensor. First, through the specific analysis of the spectral response curves of the SWIR detector and 2MASS detection bandpasses, the method of estimating instrument magnitudes for the All-Time sensor is determined. Subsequently, dynamic detectable magnitude limits are determined through the signal-to-noise model and the atmospheric background radiation intensity analysis. Based on the dynamic detectable magnitude limits, a reduction method is proposed. The simulation experiment results indicate that the RMS error of the estimation of instrument magnitude is 0.075. Compared to the magnitude filtering method, the guide star catalog obtained through our method can guarantee the completeness, besides, the global distribution uniformity increases by 2.2 times and the local distribution uniformity increases by 10.7 times.

As an important development direction of star sensor technology, the All-Time star sensor technology can expand the application of star sensors to flight platforms inside the atmosphere. Due to intense atmospheric background radiation during the daytime, the commonly used star sensors operating in the visible wavelength range are significantly limited in their ability to detect stars, and hence the All-Time star sensor technology which is based on the shortwave infrared (SWIR) imaging system has become an effective research direction. All-Time star sensor detection capability is significantly affected by observation conditions and, therefore, an optimized selection of optical parameters, which mainly includes the field of view (FOV) and the detection wavelength band, can effectively improve the detection performance of All-Time star sensors under harsh observation conditions. This paper uses the model simulation method to analyze and optimize the optical parameters under various observation conditions in a high-altitude environment. A main parameter among those discussed is the analysis of detection band optimization based on the SWIR band. Due to the huge cost constraints of high-altitude experiments, we conducted experiments near the ground to verify the effectiveness of the detection band selection and the correctness of the SWIR star sensor detection model, which thereby proved that the optimization of the optical parameters for high altitudes was effective and could be used as a reference.

Four new abietane diterpenes (1-4) and two new cycloparvifloralone-type sesquiterpenoids (5-6) have been isolated from the twigs and leaves of Illicium majus, together with three known sesquiterpenoids and five known diterpenoids. Their structures were determined by spectroscopic analysis and chemical methods. The absolute configuration of the 15,16-diol moiety in 2 is confirmed by Snatzke's method, observing the induced circular dichroism after the addition of dimolybdenum tetraacetate in DMSO. Compound 2 exihibited significant anti-inflammatory activity with an IC50 value of 0.26 ± 0.03 µM, while compounds 10, 11, and 13 showed good anti-inflammatory activities with IC50 values ranging from 1.94 ± 0.56 to 2.60 ± 0.48 µM.