Diterpenoids and Sesquiterpenoids from the Twigs and Leaves of Illicium majus

Zhen‐Feng Fang(Chinese Academy of Medical Sciences & Peking Union Medical College), Guijie Zhang(Chinese Academy of Medical Sciences & Peking Union Medical College), Hui Chen(Chinese Academy of Medical Sciences & Peking Union Medical College), Jian Bai(Chinese Academy of Medical Sciences & Peking Union Medical College), Shi‐Shan Yu(Chinese Academy of Medical Sciences & Peking Union Medical College), Yang Liu(Chinese Academy of Medical Sciences & Peking Union Medical College), Wenjie Wang(Chinese Academy of Medical Sciences & Peking Union Medical College), Shuang‐Gang Ma(Chinese Academy of Medical Sciences & Peking Union Medical College), Jing Qu(Chinese Academy of Medical Sciences & Peking Union Medical College), Song Xu(Chinese Academy of Medical Sciences & Peking Union Medical College)
Planta Medica
December 18, 2012
10.1055/s-0032-1328056
Cited by 18

Abstract

Four new abietane diterpenes (1-4) and two new cycloparvifloralone-type sesquiterpenoids (5-6) have been isolated from the twigs and leaves of Illicium majus, together with three known sesquiterpenoids and five known diterpenoids. Their structures were determined by spectroscopic analysis and chemical methods. The absolute configuration of the 15,16-diol moiety in 2 is confirmed by Snatzke's method, observing the induced circular dichroism after the addition of dimolybdenum tetraacetate in DMSO. Compound 2 exihibited significant anti-inflammatory activity with an IC50 value of 0.26 ± 0.03 µM, while compounds 10, 11, and 13 showed good anti-inflammatory activities with IC50 values ranging from 1.94 ± 0.56 to 2.60 ± 0.48 µM.

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