AstraZeneca (South Korea)
ORCID: 0000-0002-4514-5751Publishes on Radical Photochemical Reactions, Crystallization and Solubility Studies, X-ray Diffraction in Crystallography. 26 papers and 758 citations.
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oxidative ring opening of cyclic alkylketone oxime ethers. The redox properties of the dyes were determined by both cyclic voltammetry and computation and covered an existing gap in the oxidation potential of photoredox organocatalysts.
Organic dyes have emerged as a reliable class of photoredox catalysts. Their great structural variety combined with the easy fine-tuning of their electronic properties has unlocked new possibilities for the generation of reactive intermediates. In this review, we provide an overview of the available approaches to access reactive intermediates that employ organophotocatalysis. Our contribution is not a comprehensive description of the work in the area but rather focuses on key concepts, accompanied by a few selected illustrative examples. The review is organized along the type of reactive intermediates formed in the reaction, including C(sp 3 ) and C(sp 2 ) carbon-, nitrogen-, oxygen-, and sulfur-centered radicals, open-shell charged species, and sensitized organic compounds.
We report the first decarboxylative alkynylation of the C-terminus of peptides starting from free carboxylic acids. The reaction is fast, metal-free, and proceeds cleanly to afford alkynylated peptides with a broad tolerance for the C-terminal amino acid. By the use of hypervalent iodine reagents, the introduction of a broad range of functional groups was successful. C-terminal selectivity was achieved by differentiation of the oxidation potentials of the carboxylic acids based on the use of fine-tuned organic dyes.
An organic photoredox catalyst, 4CzIPN, was used in combination with a copper catalyst, CuCl, to effect decarboxylative C(sp3)–N coupling. The coupling worked with both anilines and imines as nitrogen sources and could be used to prepare a variety of alkyl amines from readily available alkyl carboxylic acids.
Abstract Une série de sélénophènes mono‐ et bisubstitués est étudiée en résonance de 1 H et 13 C. Les déplacements chimiques protoniques sont analysés en termes d'effets d'anisotropie et de champ électrique des substituants et utilisés à une discussion des équilibres conformationnels. Les relations entre δ 1 H et δ 13 C et les charges π calculées par la méthode PPP sont examinées. Les couplages 1 J ( 13 CH), n J ( 13 C ∼ H) et 1 J ( 13 C 77 Se) se révèlent de bonnes caractéristiques structurales et des relations d'additivité sont dégagées pour δ 13 C.