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Philippe Walter

Centre National de la Recherche Scientifique

ORCID: 0000-0002-1804-8374

Publishes on Cultural Heritage Materials Analysis, Medieval European Literature and History, Building materials and conservation. 495 papers and 11.9k citations.

495Publications
11.9kTotal Citations

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Top publicationsby citations

<i>Staphylococcus aureus</i> RNAIII and Its Regulon Link Quorum Sensing, Stress Responses, Metabolic Adaptation, and Regulation of Virulence Gene Expression
Delphine Bronesky, Zongfu Wu, Stefano Marzi et al.|Annual Review of Microbiology|2016
Cited by 210

Staphylococcus aureus RNAIII is one of the main intracellular effectors of the quorum-sensing system. It is a multifunctional RNA that encodes a small peptide, and its noncoding parts act as antisense RNAs to regulate the translation and/or the stability of mRNAs encoding transcriptional regulators, major virulence factors, and cell wall metabolism enzymes. In this review, we explain how regulatory proteins and RNAIII are embedded in complex regulatory circuits to express virulence factors in a dynamic and timely manner in response to stress and environmental and metabolic changes.