<i>Staphylococcus aureus</i> RNAIII and Its Regulon Link Quorum Sensing, Stress Responses, Metabolic Adaptation, and Regulation of Virulence Gene Expression
Delphine Bronesky(Centre National de la Recherche Scientifique), Zongfu Wu(Nanjing Agricultural University), Stefano Marzi(Centre National de la Recherche Scientifique), Philippe Walter(Centre National de la Recherche Scientifique), Thomas Geissmann(Université Claude Bernard Lyon 1), Karen Moreau(Université Claude Bernard Lyon 1), François Vandenesch(Université Claude Bernard Lyon 1), Isabelle Caldelari(Centre National de la Recherche Scientifique), Pascale Romby(Centre National de la Recherche Scientifique)
Cited by 210
Abstract
Staphylococcus aureus RNAIII is one of the main intracellular effectors of the quorum-sensing system. It is a multifunctional RNA that encodes a small peptide, and its noncoding parts act as antisense RNAs to regulate the translation and/or the stability of mRNAs encoding transcriptional regulators, major virulence factors, and cell wall metabolism enzymes. In this review, we explain how regulatory proteins and RNAIII are embedded in complex regulatory circuits to express virulence factors in a dynamic and timely manner in response to stress and environmental and metabolic changes.
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