A. V. Borisova

Research concerned with predictors of talent in football has highlighted a number of potentially important and partially inherited measures such as body size, anaerobic power, aerobic capacity, agility, psychological profile, game intelligence and susceptibility to injuries. Genotyping for performance-associated DNA polymorphisms at an early age could be useful in predicting later success in football. The aim of the study was to investigate individually and in combination the association of common gene polymorphisms with football player's status. A total of 246 Russian football players and 872 controls were genotyped for 8 gene polymorphisms, which were previously reported to be associated with athlete status. Four alleles (ACE D, ACTN3 Arg577, PPARA rs4253778 C and UCP2 55Val) were first identified, showing discrete associations with football player's status. Next, we determined the total genotype score (TGS, from the accumulated combination of the 4 polymorphisms, with a maximum value of 100 for the theoretically optimal polygenic score) in athletes and controls. The mean TGS was significantly higher in football players (52.0 (17.6) vs. 41.3 (15.5); P < 0.0001) than in controls. These data suggest that the likelihood of becoming a football player depends on the carriage of a high number of "favourable" gene variants.

Gabbasov, RT, Arkhipova, AA, Borisova, AV, Hakimullina, AM, Kuznetsova, AV, Williams, AG, Day, SH, and Ahmetov, II. The HIF1A gene Pro582Ser polymorphism in Russian strength athletes. J Strength Cond Res 27(8): 2055–2058, 2013—Hypoxia-inducible factor-1α (encoded by HIF1A gene) controls a number of genes that are implicated in various cellular functions including glycolysis and cell proliferation and differentiation. The rs11549465 C > T polymorphism in the HIF1A gene, which produces the amino acid substitution Pro582Ser, increases protein stability and transcriptional activity and, therefore, improves glucose metabolism. The aim of our study was to investigate the association between the HIF1A Pro582Ser polymorphism and elite strength athlete status. A total of 208 Russian strength athletes (122 weightlifters and 86 wrestlers) of regional or national competitive standard and 1,413 controls were genotyped using the polymerase chain reaction-restriction fragment length polymorphism method. We found that the frequency of the HIF1A 582Ser variant was significantly higher in weightlifters (13.1%, p = 0.0031) and wrestlers (15.7%, p = 0.0002) compared with the controls (7.5%). Additionally, the highest (21.1%, p = 0.0052) frequency of the 582Ser variant was found in a group of elite strength athletes. Thus, our study provides evidence for an association between the HIF1A gene Pro582Ser polymorphism and elite strength athlete status. Although more replication studies are needed, the preliminary data suggest an opportunity to use the analysis of HIF1A polymorphism along with other gene variations and standard phenotypic assessment in sports selection.

Obesity is a multifactorial disease which depends on the interaction between genome and environment. Fatty acid-binding protein 2 (FABP2) regulates lipid transport, intestinal absorption and metabolism. The aim of the study was to investigate the interrelation between the FABP2 gene Ala54Thr polymorphism, body mass index and body fat mass and to study distribution of genotypes and alleles frequencies of FABP2 gene in athletes and individuals who are not involved in sports. 315 athletes of different sport disciplines and levels and 612 controls (predominantly students) participated in the study. Genotyping for the FABP2 gene Ala54Thr polymorphism was performed by PCR. Body composition was analyzed by bioimpedance method. The study did not confirm the association of FABP2 gene Ala54Thr polymorphism with the risk of obesity and body fat mass. However, the frequency of the Thr54 allele was significantly higher in elite stayers (50.0%, p = 0.025) and combat athletes (46.2%, p = 0.013) in comparison with controls (32.2%). Thus, FABP2 gene Ala54Thr polymorphism is associated with the predisposition to endurance athletic performance.

Justification : This work is the integration of safer and more effective drugs into clinical practice to optimize pain relief and reduce the risks associated with the use of traditional opioid analgesics. Objective: to evaluate the effectiveness of pain relief in the early postoperative period using non-opioid analgesics (ibuprofen, tafalgin, nefopam) in patients with mine-blast wounds (MBW) accompanied by traumatic amputations of the limbs. Methods : The study included 45 patients randomly assigned to three groups depending on the analgesic used: ibuprofen, tafalgin or nefopam. Results : In all groups, there was a significant decrease in the need for additional postoperative analgesia, including opioid drugs. Nefopam provided the most pronounced analgesic effect, reducing pain intensity on the VAS scale more than ibuprofen and tafalgin. However, its use was accompanied by a higher frequency of side effects (dizziness, tachycardia, hypertension). Ibuprofen demonstrated an optimal combination of analgesic efficacy and safety, with a minimal frequency of side effects. Conclusion: Nefopam has a pronounced analgesic effect in the early postoperative period in patients with MVR, but is associated with an increased frequency of side effects. Ibuprofen showed a high level of safety and sufficient efficacy, which makes it a preferred component of multimodal analgesia for this category of patients.

Objective: evaluation of the feasibility of using the Borg CR10 perceived exertion scale in the training process of young football players and its role in injury prevention. Material and methods: 48 athletes aged 15–17 were examined by scale of perceived exertion during the 7 month every day within 20 minutes after the training. The coaches also assessed the degree of perceived exertion. A comparative retrospective analysis of injuries was done for the periods of the mycrocycle of the youth football league of the seasons 2020–2021 and 2021–2022 based on muscle injuries, ligament and joint capsular injuries. Results: Athletes’ scores on the Borg CR10 scale in the preparation, competition and transitional stages of the competitive macrocycle are 5.08 ± 1.28, 5.00 ± 1.16 and 4.67 ± 1.38, respectively. The coaches’ scores for the aforementioned periods are 4.78 ± 0.89, 5.09 ± 1.05 and 4.82 ± 0.99. The total scores of players and coaches is 5.20 ± 1.85 and 4.96 ± 1 respectively. Moreover, there is no statistically significant difference between the rate of perceived exertion between players and coaches for the whole season (p = 0.288). There is a decreased injury rate in young professional athletes group when the Borg CR10 scale of perceived exertion is measured in a season with the use of this scale compared to a season where the Borg CR 10 scale was not used (p = 0,028). Conclusion: the Borg СR10 scale is a useful methodology for assessing the level of perceived exertion of a young athlete and can be used for early training corrections in order to reduce injuries.