A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.Yasuhiro Matsumura, Hiroshi Maeda|PubMed|1986Cited by 6.8k
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a reviewHiroshi Maeda, K. Hori, Jun Wu et al.|Journal of Controlled Release|2000Cited by 6.5k
The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effectJun Fang, Hiroshi Maeda, Hideaki Nakamura|Advanced Drug Delivery Reviews|2010Cited by 3.5k
The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targetingHiroshi Maeda|Advances in Enzyme Regulation|2001Cited by 2.5k
The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivoHiroshi Maeda, Jun Fang, Hideaki Nakamura|Advanced Drug Delivery Reviews|2012Cited by 2.3k