The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effectJun Fang, Hiroshi Maeda, Hideaki Nakamura|Advanced Drug Delivery Reviews|2010Cited by 3.5k
The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivoHiroshi Maeda, Jun Fang, Hideaki Nakamura|Advanced Drug Delivery Reviews|2012Cited by 2.3k
Exploiting the enhanced permeability and retention effect for tumor targetingArun K. Iyer, Hiroshi Maeda, Khaled Greish et al.|Drug Discovery Today|2006Cited by 1.8k
Exploiting the dynamics of the EPR effect and strategies to improve the therapeutic effects of nanomedicines by using EPR effect enhancersJun Fang, Hiroshi Maeda, Waliul Islam|Advanced Drug Delivery Reviews|2020Cited by 723
Therapeutic strategies by modulating oxygen stress in cancer and inflammationJun Fang, Hiroshi Maeda, Takahiro Seki|Advanced Drug Delivery Reviews|2009Cited by 542