M S SEGAL

The advent of mechanical respirators supplied a useful tool for assisting inadequate respiration (1-4). Segal and Dulfano suggested a practical abbreviated terminology for the various forms of pressure breathing therapy (5). Intermittent positive pressure breathing (IPPB II), producing a gradual increase of positive pressure during inspiration with a rapid fall of expiratory pressure to ambient levels, is considered most effective in producing hyperventilation (6-8). The application of a negative expiratory phase, although considered beneficial in patients with respiratory muscular paralysis (9, 10), has not found favor in the management of patients with b:onchospa~m and chronic diffuse pulmonary dIsease; mamly because the negative expiratory phase mcreases the hazards of bronchiolar collapse and consequent increase in air trapping (11, 12). . The effects of IPPB II in chronic pulmonary dIseases have been studied extensively and found useful by most investigators (13-23). Many of the reports are based on the clinical response without critical attempts to separate the bronchodilator and the oxygen effects from the effect of t~e IPPB/I alone. Moreover, the groups studIed were not clinically homogeneous and the findings not necessarily applicable to all the pulmonary patients. Cullen (16) thought that patients with severe bronchopulmonary obstruction and marked pulmonary failure might not respond as well to IPPB II, but Fraimow disputed this (24). Clinically, the writers have frequently noted that the effects of IPPB II are unsatisfactory in seriously ill patients with chronic diffuse obstructive emphysema. The patient would struggle, resist the machine, and tire easily,

Article1 October 1949PHARMACODYNAMICS OF PULMONARY ABSORPTION IN MAN. I. AEROSOL AND INTRATRACHEAL PENICILLINEDWARD A. GAENSLER, JOHN F. BEAKEY, MAURICE S. SEGAL, F.A.C.P.EDWARD A. GAENSLERSearch for more papers by this author, JOHN F. BEAKEYSearch for more papers by this author, MAURICE S. SEGAL, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-31-4-582 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDirect medication of the pulmonary epithelium is not a new development in therapeutics. It is readily understandable why interest in this accessible direct route of therapy should have developed during the early attempts to treat pulmonary disease. With the advent of successful specific oral and parenteral therapy, however, interest in primary medication of the lungs began to lag. The musculotropic and neurotropic action of bronchodilators, the belladonna group of alkaloids, and others, on the musculature and secretory cells of the bronchi was striking. Even more striking, however, was the immediate and prolonged relief afforded the asthmathic by the inhalation of...Bibliography1. GRAESERROWE JBAH: Inhalation of epinephrine for the relief of asthmatic symptoms, Jr. Allergy, 1935, vi, 415-420. CrossrefGoogle Scholar2. BRYSONSANSOMELASKIN VES: Aerosolization of penicillin solutions, Science, 1944, c, 33-35. CrossrefGoogle Scholar3. BARACHSILBERSTEINOPPENHEIMERHUNTERSOROKA ALFHETTM: Inhalation of penicillin aerosol in patients with bronchial asthma, chronic bronchitis, bronchiectasis and lung abscess: preliminary report, Ann. Int. Med., 1945, xxii, 485. Google Scholar4. SEGALRYDER MSCM: Penicillin aerosolization in the treatment of serious respiratory infections. A preliminary report, New England Jr. Med., 1945, ccxxxiii, 747. CrossrefGoogle Scholar5. RICHARDSBARACHCROMWELL DWALHA: Use of vaporized bronchodilator solutions in asthma and emphysema. A continuous inhalation method for severe asthmatic states, Am. Jr. Med. Sci., 1940, cxcix, 225-232. CrossrefGoogle Scholar6. WINTERNITZSMITH MCGH: Preliminary studies in intratracheal therapy, collected studies on the pathology of war gas poisoning, 1920, Yale University Press, New Haven. Google Scholar7. COURTICEPHIPPS FCPJ: The absorption of fluids from the lungs, Jr. Physiol., 1946, cv, 186-190. CrossrefGoogle Scholar8. DRINKERHARDENBERGH CKE: Absorption from the pulmonary alveoli, Jr. Exper. Med., 1947, lxxxvi, 7-18. CrossrefGoogle Scholar9. RAWSON RA: The binding of T-1824 and structurally related diazo dyes by the plasma proteins, Am. Jr. Physiol., 1943, cxxxviii, 708-717. CrossrefGoogle Scholar10. ABRAHAMCHAINFLETCHERGARDNERHEATLYJENNINGSFLOREY EPECMADNGMAHW: Further observations on penicillin, Lancet, 1941, ii, 177-186. CrossrefGoogle Scholar11. RAMMELKAMPKEEFER CHCS: Penicillin: its antibacterial effect on whole blood and serum for hemolytic streptococcus and Staphylococcus aureus , Jr. Clin. Invest., 1943, xxii, 649-657. CrossrefGoogle Scholar12. RAMMELKAMPBRADLEY CHSE: Excretion of penicillin in man, Proc. Soc. Exper. Biol. and Med., 1943, liii, 30-32. CrossrefGoogle Scholar13. FREEPARKERBIRO AHRFBE: Oral penicillin: a comparison of various modes of administration, Science, 1945, cii, 666-668. CrossrefGoogle Scholar14. BAYERPETERSWOODWARDVERWEY KHLRWF: The enhancement of the physiological economy of penicillin in dogs by simultaneous administration of para-aminohippuric acid, Jr. Pharmacol. and Exper. Therap., 1944, lxxxii, 310-323. Google Scholar15. BRONFENBRENNERFAVOUR JCB: Increasing and prolonging blood penicillin concentrations following intramuscular administration, Science, 1945, ci, 673-674. CrossrefGoogle Scholar16. BEYER KH: New concept of competitive inhibition of the renal tubular excretion of penicillin, Science, 1947, cv, 94-95. CrossrefGoogle Scholar17. BEAKEYGAENSLERSEGAL JFEAMS: A comparative study of various apparatus and technique for aerosol administration, Conn. State Med. Jr., 1949, xiii, 855-863. Google Scholar18. DERBESENGELHARDT VJHT: Deaths following the use of local anesthetics in transcricoid therapy: a clinical evaluation, Jr. Lab. and Clin. Med., 1944, xxix, 478-482. Google Scholar19. RAMMELKAMP CH: A method of determining the concentration of penicillin in body fluids and exudates, Proc. Soc. Exper. Biol. and Med., 1942, li, 95. CrossrefGoogle Scholar20. FINLANDMEADSORY MMEM: Oral penicillin, Jr. Am. Med. Assoc., 1945, cxxix, 315-326. CrossrefGoogle Scholar21. BIGGER JN: Inactivation of penicillin by serum, Lancet, 1944, ii, 400. CrossrefGoogle Scholar22. EAGLETUCKER HHA: The effect of serum on the in vitro bioassay of penicillin, 1948, in preparation. Quoted by EAGLE, H.: Speculations as to the therapeutic significance of the penicillin blood level, Ann. Int. Med., 1948, xxviii, 260-278. Google Scholar23. LITTLELUMB CJG: Penicillin by mouth, Lancet, 1945, ccxlviii, 203. CrossrefGoogle Scholar24. HARVEY BC: Simple lessons in anatomy, Am. Med. Assoc., 1932. Quoted by PRIGAL, S. G.: Studies with medicated aerosols, 1948, xxviii, 814-828. Google Scholar25. BEAKEYGAENSLERSEGAL JFEAMS: Pharmacodynamics of pulmonary absorption in man. II. The influence of various diluents on aerosol and intratracheal penicillin. To appear in November 1949 issue, Ann. Int. Med. Google Scholar26. INGRAHAMGAENSLER FDEA: Unpublished data, 1944. Google Scholar27. KAYMEADE EBRH: Penicillin in the treatment of chronic infections of the lungs and bronchi; analysis of 93 cases, Jr. Am. Med. Assoc., 1945, cxxix, 200-204. CrossrefGoogle Scholar28. MOORETHOMPSON FHJW: Intrabronchial instillation of penicillin or sulfonamide solution, with bronchial lavage, in the treatment of severe bronchiectasis, Naval Med. Bull., 1945, xlv, 1097-1103. Google Scholar29. BOBROWITZEDLINBASSINWOOLEY IDJSSJS: Penicillin in the treatment of bronchiectasis, New England Jr. Med., 1946, ccxxxiv, 141-147. CrossrefGoogle Scholar30. ROMANSKYDUGANRITTMAN MJDJGE: Penicillin in iodized oil for instillation into the lungs, Science, 1945, cii, 255-256. CrossrefGoogle Scholar31. GAENSLERBEAKEYSEGAL EAJFMS: The relative effectiveness of parenteral, intratracheal and aerosol penicillin in chronic suppurative disease of the lung, Jr. Thorac. Surg., 1949, xviii, 546-560. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication September 11, 1948.From the Department of Inhalational Therapy, Boston City Hospital, and the Department of Medicine, Tufts College Medical School. This study was aided by a grant from the Commercial Solvents Corporation. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAlternative Methods of Drug AdministrationPostoperative Pain Treatment by Means of a Morphine Aerosol: A Multicenter StudyEfficacy of absorption of sublingual and intravenous cardio-greenEndotracheal drug therapyA simple method for administering endotracheal medicationBlood levels of diazepam after endotracheal administration in dogsAuthor's replyLOCALIZED PULMONARY DISEASESBibliographyBronchiectasisAsthma bronchialeXIX Studies with Steam Generated Aerosols 1 October 1949Volume 31, Issue 4Page: 582-594KeywordsBronchiBronchodilatorsCellsEpitheliumHospital medicineInhalationLungsPenicillinPharmacodynamicsPulmonary diseases ePublished: 1 December 2008 Issue Published: 1 October 1949 PDF downloadLoading ...

Article1 June 1958THE MECHANICS OF BREATHING IN NORMAL SUBJECTS AND IN PATIENTS WITH CARDIOPULMONARY DISEASEERNST O. ATTINGER, M.D., MERRILL M. GOLDSTEIN, M.D., MAURICE S. SEGAL, M.D., F.A.C.P.ERNST O. ATTINGER, M.D.Search for more papers by this author, MERRILL M. GOLDSTEIN, M.D.Search for more papers by this author, MAURICE S. SEGAL, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-48-6-1269 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA number of reports have appeared during recent years on the changes of the physical properties of the lung in cardiopulmonary diseases.1-26 Valuable new information has been obtained on the fundamental nature of different disorders, though only a comparatively small number of subjects have been studied. It is the purpose of this report to describe the results on a series of 100 subjects: 25 normal subjects and 75 patients with various types of cardiopulmonary disease.MATERIAL AND METHODSThe subjects were studied in the basal state and in the supine position. Transpulmonary pressures, instantaneous air flow rates and tidal volumes...Bibliography1. MeadWhittenberger JJL: Physical properties of human lungs measured during spontaneous respiration, J. Appl. Physiol. 5: 779, 1953. CrossrefGoogle Scholar2. McIlroyMarshallChristie MBRRV: The work of breathing in normal subjects, Clin. Sc. 13: 127, 1954. MedlineGoogle Scholar3. DuBoisBotelhoComroe ABSYJH: A new method for measuring airway resistance in man using a body plethysmograph: values in normal subjects and in patients with respiratory disease, J. Clin. Investigation 35: 327, 1956. CrossrefMedlineGoogle Scholar4. FrankMeadSiebensStorey NRJAACF: Measurement of pulmonary compliance in 70 healthy young adults, J. Appl. Physiol. 9: 38, 1956. CrossrefMedlineGoogle Scholar5. CookCherryO'BrienKarlbergSmith CDRBDPCA: Studies of respiratory physiology in the newborn infant. I. Observations on normal, premature and full-term infants, J. Clin. Investigation 34: 975, 1955. CrossrefMedlineGoogle Scholar6. McIlroyTomlinson MBES: The mechanics of breathing in newly born babies, Thorax 10: 58, 1955. CrossrefMedlineGoogle Scholar7. MarshallChristie RRV: The visco-elastic properties of the lungs in acute pneumonia, Clin. Sc. 13: 403, 1954. MedlineGoogle Scholar8. Dayman H: Mechanics of airflow in health and in emphysema, J. Clin. Investigation 30: 1175, 1951. CrossrefMedlineGoogle Scholar9. SteadFryEbert WMDLRV: The elastic properties of the lung in normal men and in patients with chronic pulmonary emphysema, J. Lab. and Clin. Med. 40: 674, 1952. MedlineGoogle Scholar10. FryEbertSteadBrown DLRVWMCC: The mechanics of pulmonary ventilation in normal subjects and in patients with emphysema, Am. J. Med. 16: 80, 1954. CrossrefMedlineGoogle Scholar11. McIlroyChristie MBRV: The work of breathing in emphysema, Clin. Sc. 13: 147, 1954. MedlineGoogle Scholar12. MeadLindgrenGaensler JIEA: The mechanical properties of the lungs in emphysema, J. Clin. Investigation 34: 1005, 1955. CrossrefMedlineGoogle Scholar13. Cherniak RM: The physical properties of the lung in chronic obstructive pulmonary emphysema, J. Clin. Investigation 35: 394, 1956. CrossrefMedlineGoogle Scholar14. AttingerGoldsteinSegal EOMMMS: Ventilation in chronic pulmonary emphysema. II. Correlation of compliance and mechanical resistance with routine pulmonary function tests, Am. Rev. Tuberc. and Pul. Dis. 74: 220, 1956. Google Scholar15. Neolpp-EschenhagenNoelpp IB: New contributions to experimental asthma, Progress in Allergy 4: 361, 1954. Google Scholar16. NoelppNoelpp-EschenhagenLottenbach BIK: Das Verhalten der elastischen Lungenspannung und des Gewebs-Deformationswiderstandes bei der experimentellen asthmatiformen Dyspnoe, Internat. Arch. Allergy 5: 245, 1954. CrossrefGoogle Scholar17. McIlroyMarshall MBR: The mechanical properties of the lungs in asthma, Clin. Sc. 15: 345, 1956. MedlineGoogle Scholar18. MarshallMcIlroyChristie RMBRV: The work of breathing in mitral stenosis, Clin. Sc. 13: 137, 1954. MedlineGoogle Scholar19. BrownFryEbert CCDLRV: The mechanics of pulmonary ventilation in patients with heart disease, Am. J. Med. 17: 438, 1954. CrossrefMedlineGoogle Scholar20. HaywardKnott GWJM: The effect of exercise on lung distensibility and respiratory work in mitral stenosis, Brit. Heart J. 17: 303, 1955. CrossrefMedlineGoogle Scholar21. SaxtonRabinowitzDexterHaynes GAMLF: The relationship of pulmonary compliance to pulmonary vascular pressures in patients with heart disease, J. Clin. Investigation 35: 611, 1956. CrossrefMedlineGoogle Scholar22. OtisBembower ABWC: Effect of gas density on resistance to respiratory gas flow in man, J. Appl. Physiol. 2: 300, 1949. CrossrefMedlineGoogle Scholar23. OtisRahnFenn ABHWO: Venous pressure changes associated with positive intrapulmonary pressure: their relationship to the distensibility of the lung, Am. J. Physiol. 146: 307, 1946. CrossrefMedlineGoogle Scholar24. FerrisMeadWhittenbergerSaxton BJJLGA: Pulmonary function in convalescent polio patients, New England J. Med. 247: 390, 1952. CrossrefMedlineGoogle Scholar25. ScherrerKostyalWierzejewskiSchmidtGeuns MAHFHA: Zur Pathophysiologie des provozierten bronchial-asthmatischen Anfalls, Internat. Arch. Allergy 9: 65, 1956. CrossrefGoogle Scholar26. MarshallDuBois RAB: The viscous resistance of lung tissue in patients with pulmonary disease, Clin. Sc. 15: 473, 1956. MedlineGoogle Scholar27. AttingerMonroeSegal EORGMS: The mechanics of breathing in different body positions. I. In normal subjects, J. Clin. Investigation 35: 904, 1956. CrossrefMedlineGoogle Scholar28. BaldwinCournandRichards EDADW: Pulmonary insufficiency. I. Physiological classification, clinical methods of analysis, standard values in normal subjects, Medicine 27: 243, 1948. CrossrefMedlineGoogle Scholar29. AttingerDow EOJ: The relation of intrathoracic pressure changes to respiratory pressure changes within the pulmonary vasculature, to be published. Google Scholar30. OtisMcKerrowBartlettMeadMcIlroySelverstoneRadford ABCBRAJMBNJEP: Mechanical factors in distribution of pulmonary ventilation, J. Appl. Physiol. 8: 427, 1956. CrossrefMedlineGoogle Scholar31. AttingerSegal EOMS: Ventilation and the mechanics of breathing in clinical cardiopulmonary physiology, edited by Gordon, B., 1957, Grune & Stratton, Inc., New York. Google Scholar32. AttingerHerschfusSegal EOAJMS: Mechanics of breathing in different body positions. II. In patients with cardiopulmonary disease, J. Clin. Investigation 35: 912, 1956. CrossrefMedlineGoogle Scholar33. ButlerArnott JWM: The work of pulmonary ventilation at different respiratory levels, Clin. Sc. 14: 703, 1955. MedlineGoogle Scholar34. MarshallDuBois RAB: The measurement of the viscous resistance of the lung tissues in normal man, Clin. Sc. 15: 161, 1956. MedlineGoogle Scholar35. O'NealThomasLeeRabin RMWAKTER: Alveolar walls in mitral stenosis, Circulation 15: 64, 1957. CrossrefMedlineGoogle Scholar36. BondurantHickam SJB: Pulmonary and circulatory effects of acute pulmonary vascular engorgement in normal subjects, J. Clin. Investigation 35: 692, 1956 (abstract). Google Scholar37. MackGrossmanKatz IMLN: The effect of pulmonary vascular congestion on the distensibility of the lungs, Am. J. Physiol. 150: 654, 1947. CrossrefMedlineGoogle Scholar38. Gaensler EA: Air velocity index: numerical expression of functionally effective position of ventilation, Am. Rev. Tuberc. 62: 17, 1950. MedlineGoogle Scholar39. D'Silva JL: Mechanical function of the lungs, Brit. J. Phys. Med. 15: 129, 1952. Google Scholar40. Bernstein L: The discontinuity in the pressure-volume curve of the rabbit's lung, J. Physiol. 124: 35, 1954. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ERNST O. ATTINGER, M.D.; MERRILL M. GOLDSTEIN, M.D.; MAURICE S. SEGAL, M.D., F.A.C.P.Affiliations: Boston, Massachusetts*Received for publication May 1, 1957.From the Department of Medicine, Tufts University School of Medicine, and the Lung Station (Tufts) and Department of Inhalation Therapy, Boston City Hospital, Boston, Massachusetts.†Work done during tenure of a Research Fellowship of the American Heart Association.Requests for reprints should be addressed to Maurice S. Segal, M.D., Department of Inhalation Therapy, Boston City Hospital, Boston 18, Massachusetts. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byReference values for dynamic and static pulmonary compliance in menSignificance of relative rib cage and abdomen motion in patients with chronic obstructive pulmonary diseaseChanges in Pulmonary Compliance in Patients Undergoing Cardiac SurgeryIntensivpflege bei respiratorischer InsuffizienzAtemmechanik (Oesophagusdruckmethode)PRESSURE-CYCLED VENTILATORSl"�ber Lungenschwellung und Lungenstarrheit?: Atemmechanische Untersuchungen an 100 MitralstenosenDYNAMIC SPIROMETRY STUDIES IN PATIENTS WITH LUNG DISEASE.Effect of Tracheostomy Tubes on the Resistance to Breathing and Pulmonary Resistance in Patients with PoliomyelitisDie klinische Bewertung elastischer und visc�ser Atemwiderst�nde und der AtemarbeitSTUDIES ON THE REGISTRATION OF PROVOCATION TESTS FOR THE ETIOLOGICAL DIAGNOSIS OF BRONCHIAL ASTHMATimed vital capacity a correlation with maximal breathing capacity and use as a clinical test of ventilatory function 1 June 1958Volume 48, Issue 6 Page: 1269-1288 Keywords Air flow Breathing Emphysema Fellowships Heart Hospital medicine Inhalation Lungs Respiration Tidal volume ePublished: 1 December 2008 Issue Published: 1 June 1958 PDF downloadLoading ...

Article1 July 1950A CLINICOPATHOLOGIC STUDY OF BRONCHIAL ASTHMA WITH CONSIDERATION OF ITS RELATIONSHIP TO THE "GENERAL ADAPTATION SYNDROME"BERTRAM M. WINER, JOHN F. BEAKEY, MAURICE S. SEGAL, F.A.C.P.BERTRAM M. WINERSearch for more papers by this author, JOHN F. BEAKEYSearch for more papers by this author, MAURICE S. SEGAL, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-33-1-134 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONBronchial asthma has been a subject of controversy among clinicians and pathologists since the recognition of this disease. Salter,1almost a century ago, stated that ". . . asthma is a disease about whose pathology more various and discrepitant ideas prevail than about any other disease that could be named. . . ." The first major study of the pathology of this disease by Huber and Koessler2in 1922 has been followed by many individual case reports. This literature has recently been reviewed by Rackemann,3Unger4and Gay.5Because of the persistence of varied opinions concerning bronchial asthma, and...Bibliography1. Salter HH: Asthma: its pathology and treatment, 1860, John Churchill, London. Google Scholar2. HuberKoessler HLKK: Pathology of bronchial asthma, Arch. Int. Med. 30: 689-760, 1922. CrossrefGoogle Scholar3. Rackemann FM: Deaths from asthma, J. Allergy 15: 249-258, 1944. CrossrefGoogle Scholar4. Unger L: Pathology of bronchial asthma with five autopsy reports, South. M. J. 38: 513, 1945. CrossrefGoogle Scholar5. Gay LN: The diagnosis and treatment of bronchial asthma, 1946, Williams and Wilkins Co., Baltimore. Google Scholar6. KountzAlexander WBHL: Death from asthma, Arch. Path. 5: 1003, 1928. Google Scholar7. MacDonald IG: Local and constitutional pathology of bronchial asthma, Ann. Int. Med. 6: 253-277, 1932. LinkGoogle Scholar8. ThiemeSheldon ETJM: A correlation of the clinical and pathologic findings in bronchial asthma, J. Allergy 9: 246, 1938. CrossrefGoogle Scholar9. Craige B: Fatal bronchial asthma, Arch. Int. Med. 67: 399-410, 1941. CrossrefGoogle Scholar10. Waldbott GL: Pathologic changes in asthmatic infants, Am. J. Dis. Child. 49: 1531, 1935. Google Scholar11. Traisman AS: The pathology of asthma in children, Arch. Pediat. 58: 407, 1941. Google Scholar12. FaulknerWagner WBRJ: Fatal spontaneous pneumothorax and subcutaneous emphysema in asthmatic: report of case with bronchoscopic findings, J. Allergy 8: 267-272, 1937. CrossrefGoogle Scholar13. Cabot Case No. 32192, Case records of the Massachusetts General Hospital, New England J. Med. 234: 639, 1946. Google Scholar14. Salter HH: Asthma: its pathology and treatment. First American from the last English edition, 1882, Wm. Wood and Co., New York. Google Scholar15. Jackson DE: The pharmacology of bronchial asthma, J. Lab. and Clin. Med. 1: 126, 1915. Google Scholar16. GoodmanGilman LA: The pharmacological basis of therapeutics, 1941, Macmillan Co., New York. Google Scholar17. VaughnGraham WTWR: Death from asthma: a warning, J. A. M. A. 119: 556, 1942. CrossrefGoogle Scholar18. Brock JF: The danger of morphine in asthma, Clin. Proc. 2: 222-225, 1943. Google Scholar19. Cabot Case No. 20101, Case records of the Massachusetts General Hospital, New England J. Med. 210: 547, 1934. Google Scholar20. Pratt HN: Pathologic physiology of bronchial asthma in children, New England J. Med. 223: 626, 1940. CrossrefGoogle Scholar21. Moore WF: Ciliary inhibition or destruction in tracheobronchial asthma with notes on bronchoscopic treatment, Am. J. M. Sc. 169: 799, 1925. CrossrefGoogle Scholar22. Hilding AC: The relation of ciliary insufficiency to death from asthma and other respiratory diseases, Ann. Otol., Rhinol. and Laryng. 52: 5-19, 1943. Google Scholar23. BubertWarner HMCG: Fatal asthma. Report of a case with bronchial measurements, J. A. M. A. 104: 1469, 1935. CrossrefGoogle Scholar24. Cooke RA: Allergy in theory and practise, 1947, W. B. Saunders Co., Philadelphia. Google Scholar25. Mallory TB, cited by Gay, L. N., and Rienhoff, W. M.: Further observation on the treatment of intractable bronchial asthma by bilateral resection of the pulmonary plexus, Bull. Johns Hopkins Hosp. 70: 386, 1942. Google Scholar26. Paul WD: The heart in bronchial asthma, J. Iowa M. S. 25: 643, 1935. Google Scholar27. LamsonButt RWEM: Fatal "asthma." Clinical and pathologic consideration of 187 cases, J. A. M. A. 108: 1843, 1937. CrossrefGoogle Scholar28. ColtonZiskin WAT: The heart in bronchial asthma, J. Allergy 8: 347, 1937. CrossrefGoogle Scholar29. SchillerColmesDavis IWAD: The occurrence of cor pulmonale in cases of bronchial asthma, New England J. Med. 228: 113, 1943. CrossrefGoogle Scholar30. Rich AR: The pathogenesis of the forms of jaundice, Bull. Johns Hopkins Hosp. 47: 338, 1930. Google Scholar31. Selye H: Studies on adaptation, Endocrinology 21: 169-188, 1937. CrossrefGoogle Scholar32. Selye H: General adaptation syndrome and diseases of adaptation, J. Clin. Endocrinol. 6: 117-230, 1946. CrossrefGoogle Scholar33. Rich AR: The rôle of hypersensitivity in periarteritis nodosa as indicated by seven cases developing during serum sickness and sulfonamide therapy, Bull. Johns Hopkins Hosp. 71: 123-140, 1942. Google Scholar34. RichGregory ARJE: The experimental demonstration that periarteritis is a manifestation of hypersensitivity, Bull. Johns Hopkins Hosp. 72: 65-88, 1943. Google Scholar35. Moore RA: A textbook of pathology, 1944, W. B. Saunders Co., Philadelphia. Google Scholar36. Teilum G: Allergic hyperglobulinosis and hyalinosis (paramyloidosis) in the reticuloendothelial system in Boeck's sarcoid and other conditions, Am. J. Path. 24: 389-408, 1948. MedlineGoogle Scholar37. WilsonAlexander KSHL: The relation of periarteritis nodosa to bronchial asthma and other forms of human hypersensitiveness, J. Lab. and Clin. Med. 30: 195-203, 1945. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication November 27, 1948.From the Mallory Institute of Pathology, Boston City Hospital and the Department of Medicine, Tufts College Medical School.Aided by a grant from the U. S. P. H. Service. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Effects of Stress on the Respiratory SystemPsychological Factors Associated with Pediatric Asthma Death: A ReviewRelationship of psychopathology to death in asthmatic adolescentsDeaths of Institutionalized Children with Intractable Asthma: Report of Three Cases with NecropsiesRecognition and Treatment of Potentially Fatal AsthmaRONALD FELDMAN, M.D.Death in AsthmaticsHistochemical variations of the lipids of the adrenals in guinea pigs with experimental asthmaAsthma bronchialeThe pathology of bronchial asthma. I. The significance of membrane changes in asthmatic and non-allergic pulmonary diseasePressor drugs. III. Safety of inhalational therapyAdvances in inhalational therapy in the management of diseases of the chestZur Pathologie des Asthma bronchialeGeneral Practice Review 1 July 1950Volume 33, Issue 1Page: 134-162KeywordsAsthmaHospital medicinePathologists ePublished: 1 December 2008 Issue Published: 1 July 1950 PDF downloadLoading ...