Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitorsAndrea M. Zuhl, Douglas S. Johnson, Charles E. Nolan et al.|Nature Communications|2016Cited by 77
Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking HypopigmentationBrian T. O’Neill, Michael A. Brodney, Christopher R. Butler et al.|Journal of Medicinal Chemistry|2018Cited by 42
Tool Compounds Robustly Increase Turnover of an Artificial Substrate by Glucocerebrosidase in Human Brain LysatesZdenek Berger, Warren D. Hirst, Sarah E. Perkins et al.|PLoS ONE|2015Cited by 15
P4–288: Effect of A673T mutation on APP processing by BACE1 and its significance for Alzheimer's disease therapeutic researchClaude Ambroise, David Riddell, Rafael G. da Silva et al.|Alzheimer s & Dementia|2013Cited by 1
P1–109: Inhibition of BACE1 reduces beta‐amyloid 1–40 but not N‐terminal‐truncated beta‐amyloidKevin Atchison, David Riddell, Claude Ambroise et al.|Alzheimer s & Dementia|2013Cited by 0