Cited by 1.4k
Harvard–MIT Division of Health Sciences and Technology
Publishes on Tissue Engineering and Regenerative Medicine, Advanced Sensor and Energy Harvesting Materials, Electrospun Nanofibers in Biomedical Applications. 33 papers and 3.1k citations.
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= 0.0036) in the actuated group and propose that actuation-mediated strain reduces differentiation and proliferation of myofibroblasts and therefore extracellular matrix production. Computational models quantified the effect of actuation on the reservoir and surrounding fluid. By adding a porous membrane and a therapy reservoir to the DSR, we demonstrate that, with actuation, we could (i) increase transport of a therapy analog and (ii) enhance pharmacokinetics and time to functional effect of an inotropic agent. The dynamic reservoirs presented here may act as a versatile tool to further understand, and ultimately to ameliorate, the host response to implantable biomaterials.