An actuatable soft reservoir modulates host foreign body response
Eimear B. Dolan(Ollscoil na Gaillimhe – University of Galway), Claudia E. Varela(Harvard–MIT Division of Health Sciences and Technology), Keegan Mendez(Harvard–MIT Division of Health Sciences and Technology), William Whyte(Royal College of Surgeons in Ireland), Ruth E. Levey(Ollscoil na Gaillimhe – University of Galway), Scott T. Robinson(Royal College of Surgeons in Ireland), E. Maye(Ollscoil na Gaillimhe – University of Galway), Joanne O’Dwyer(Ollscoil na Gaillimhe – University of Galway), Rachel Beatty(Ollscoil na Gaillimhe – University of Galway), Arielle S. Rothman(Massachusetts Institute of Technology), Yiling Fan(Massachusetts Institute of Technology), Joshua Hochstein(Harvard–MIT Division of Health Sciences and Technology), Sandra E. Rothenbücher(Massachusetts Institute of Technology), Robert Wylie(Ollscoil na Gaillimhe – University of Galway), Jacqueline R. Starr(MRC Biostatistics Unit), Michael G. Monaghan(Ollscoil na Gaillimhe – University of Galway), Peter Dockery(Ollscoil na Gaillimhe – University of Galway), Garry P. Duffy(Royal College of Surgeons in Ireland), Ellen T. Roche(Massachusetts Institute of Technology)
Cited by 86Open Access
Abstract
= 0.0036) in the actuated group and propose that actuation-mediated strain reduces differentiation and proliferation of myofibroblasts and therefore extracellular matrix production. Computational models quantified the effect of actuation on the reservoir and surrounding fluid. By adding a porous membrane and a therapy reservoir to the DSR, we demonstrate that, with actuation, we could (i) increase transport of a therapy analog and (ii) enhance pharmacokinetics and time to functional effect of an inotropic agent. The dynamic reservoirs presented here may act as a versatile tool to further understand, and ultimately to ameliorate, the host response to implantable biomaterials.
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