Urbana University
Publishes on Advanced biosensing and bioanalysis techniques, Biosensors and Analytical Detection, Gold and Silver Nanoparticles Synthesis and Applications. 16 papers and 1.3k citations.
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A quick plunge: By using lateral flow devices as a platform to separate aptamer-assembled nanoparticle (NP) aggregates, highly sensitive and selective colorimetric sensors were constructed that mimic litmus paper tests. Detection of cocaine in serum was also realized.
Easy-to-use dipstick tests for lead have been developed by immobilizing nanoparticle-DNAzyme conjugates on lateral flow devices and their application for detecting lead in paints is demonstrated.
Design of smart MRI contrast agent based on superparamagnetic iron oxide nanoparticles and aptamers has been described for the detection of human alpha-thrombin protein. The contrast agent is based on the assembly of the aptamer functionalized nanoparticles in the presence of thrombin. A detectable change in MRI signal is observed with 25 nM thrombin in human serum. Changes were neither observed with control analytes, streptavidin, or bovine serum albumin, nor with inactive aptamer functionalized nanoparticles.
Smart agents. A contrast agent was designed by combining target specific nucleic-acid aptamers against adenosine with superparamagnetic iron oxide nanoparticles. Target-induced disassembly of clustered nanoparticles in the presence of adenosine led to an increase in T2, which was seen as an increase in the brightness of the magnetic resonance image (see figure). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2268/2007/z700323_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.