Cited by 437Open Access
Diakonessenhuis hospital
Publishes on PARP inhibition in cancer therapy, Histone Deacetylase Inhibitors Research, Retinoids in leukemia and cellular processes. 43 papers and 2.3k citations.
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Recent knowledge on apoptosis has made it possible to devise novel approaches, which exploit this process to treat cancer. In this review, we discuss in detail approaches to induce tumor cell apoptosis, their mechanism of action, stage of development, and possible drawbacks. Finally, the obstacles yet to be overcome and the perspectives for potential clinical use of apoptosis-triggering approaches in cancer therapy in the future are assessed.