Cited by 2.9k
Broad Institute
ORCID: 0000-0002-8496-6181Publishes on Immunotherapy and Immune Responses, Immune Cell Function and Interaction, Cancer Immunotherapy and Biomarkers. 273 papers and 15k citations.
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Antigen-presenting cells (APCs) can induce tolerance or immunity. We describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro. IDO-positive APCs constituted a discrete subset identified by coexpression of the cell-surface markers CD123 and CCR6. In the dendritic cell (DC) lineage, IDO-mediated suppressor activity was present in fully mature as well as immature CD123+ DCs. IDO+ DCs could also be readily detected in vivo, which suggests that these cells may represent a regulatory subset of APCs in humans.